PMID- 30753935
OWN - NLM
STAT- MEDLINE
DCOM- 20200309
LR  - 20200309
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Linking)
VI  - 25
IP  - 4
DP  - 2019 Apr
TI  - Diastolic Intra-Left Ventricular Pressure Difference During Exercise: Strong 
      Determinant and Predictor of Exercise Capacity in Patients With Heart Failure.
PG  - 268-277
LID - S1071-9164(18)31029-7 [pii]
LID - 10.1016/j.cardfail.2019.02.005 [doi]
AB  - BACKGROUND: Although the enhancement of early-diastolic intra-left ventricular 
      pressure difference (IVPD) during exercise is considered to maintain exercise 
      capacity, little is known about their relationship in heart failure (HF). METHODS 
      AND RESULTS: Cardiopulmonary exercise testing and exercise-stress 
      echocardiography were performed in 50 HF patients (left ventricular [LV] ejection 
      fraction 39 +/- 15%). Echocardiographic images were obtained at rest and submaximal 
      and peak exercise. Color M-mode Doppler images of LV inflow were used to 
      determine IVPD. Thirty-five patients had preserved exercise capacity (peak oxygen 
      consumption [VO(2)] >/=14 mL.kg(-1).min(-1); group 1) and 15 patients had reduced 
      exercise capacity (group 2). During exercise, IVPD increased only in group 1 
      (group 1: 1.9 +/- 0.9 mm Hg at rest, 4.1 +/- 2.0 mm Hg at submaximum, 4.7 +/- 2.1 mm Hg 
      at peak; group 2: 1.9 +/- 0.8 mm Hg at rest, 2.1 +/- 0.9 mm Hg at submaximum, 2.1 +/- 
      0.9 mm Hg at peak). Submaximal IVPD (r = 0.54) and peak IVPD (r = 0.69) were 
      significantly correlated with peak VO(2). Peak IVPD determined peak VO(2) 
      independently of LV ejection fraction. Moreover, submaximal IVPD could well 
      predict the reduced exercise capacity. CONCLUSION: Early-diastolic IVPD during 
      exercise was closely associated with exercise capacity in HF. In addition, 
      submaximal IVPD could be a useful predictor of exercise capacity without peak 
      exercise in HF patients.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Tsujinaga, Shingo
AU  - Tsujinaga S
AD  - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of 
      Medicine, Hokkaido University, Sapporo, Japan.
FAU - Iwano, Hiroyuki
AU  - Iwano H
AD  - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of 
      Medicine, Hokkaido University, Sapporo, Japan. Electronic address: 
      h-iwano@med.hokudai.ac.jp.
FAU - Sarashina, Miwa
AU  - Sarashina M
AD  - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of 
      Medicine, Hokkaido University, Sapporo, Japan.
FAU - Hayashi, Taichi
AU  - Hayashi T
AD  - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of 
      Medicine, Hokkaido University, Sapporo, Japan.
FAU - Murayama, Michito
AU  - Murayama M
AD  - Diagnostic Center for Sonography, Hokkaido University Hospital, Sapporo, Japan.
FAU - Ichikawa, Ayako
AU  - Ichikawa A
AD  - Division of Clinical Laboratory and Transfusion Medicine, Hokkaido University 
      Hospital, Sapporo, Japan.
FAU - Nakabachi, Masahiro
AU  - Nakabachi M
AD  - Division of Clinical Laboratory and Transfusion Medicine, Hokkaido University 
      Hospital, Sapporo, Japan.
FAU - Nishino, Hisao
AU  - Nishino H
AD  - Division of Clinical Laboratory and Transfusion Medicine, Hokkaido University 
      Hospital, Sapporo, Japan.
FAU - Yokoyama, Shinobu
AU  - Yokoyama S
AD  - Division of Clinical Laboratory and Transfusion Medicine, Hokkaido University 
      Hospital, Sapporo, Japan.
FAU - Fukushima, Arata
AU  - Fukushima A
AD  - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of 
      Medicine, Hokkaido University, Sapporo, Japan.
FAU - Yokota, Takashi
AU  - Yokota T
AD  - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of 
      Medicine, Hokkaido University, Sapporo, Japan.
FAU - Okada, Kazunori
AU  - Okada K
AD  - Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.
FAU - Kaga, Sanae
AU  - Kaga S
AD  - Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.
FAU - Vlachos, Pavlos P
AU  - Vlachos PP
AD  - School of Mechanical Engineering, Purdue University, West Lafayette, Indiana, 
      USA.
FAU - Anzai, Toshihisa
AU  - Anzai T
AD  - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of 
      Medicine, Hokkaido University, Sapporo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20190210
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
SB  - IM
MH  - Diastole
MH  - Echocardiography, Doppler
MH  - Exercise Test/*methods
MH  - Exercise Tolerance/*physiology
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/diagnosis/*physiopathology
MH  - Heart Ventricles/diagnostic imaging/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxygen Consumption
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Stroke Volume/*physiology
MH  - Ventricular Function, Left/*physiology
MH  - Ventricular Pressure/*physiology
OTO - NOTNLM
OT  - Heart failure
OT  - exercise capacity
OT  - exercise-stress echocardiography
OT  - intra-left ventricular pressure difference
EDAT- 2019/02/13 06:00
MHDA- 2020/03/10 06:00
CRDT- 2019/02/13 06:00
PHST- 2018/09/25 00:00 [received]
PHST- 2019/01/21 00:00 [revised]
PHST- 2019/02/05 00:00 [accepted]
PHST- 2019/02/13 06:00 [pubmed]
PHST- 2020/03/10 06:00 [medline]
PHST- 2019/02/13 06:00 [entrez]
AID - S1071-9164(18)31029-7 [pii]
AID - 10.1016/j.cardfail.2019.02.005 [doi]
PST - ppublish
SO  - J Card Fail. 2019 Apr;25(4):268-277. doi: 10.1016/j.cardfail.2019.02.005. Epub 
      2019 Feb 10.