PMID- 30754196
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1744-8417 (Electronic)
IS  - 1744-6651 (Linking)
VI  - 3
IP  - 3
DP  - 2008 May
TI  - Is hyperhomocysteinemia a risk factor for osteoporosis?
PG  - 309-313
LID - 10.1586/17446651.3.3.309 [doi]
AB  - Hyperhomocysteinemia (HHCY) has been accepted as a risk factor not only for 
      cardiovascular diseases (CVDs) but also for osteoporosis. Furthermore, clinical 
      data suggest that HHCY also increases fracture risk, but have no or only minor 
      effects on bone mineral density (BMD). Measurement of biochemical bone turnover 
      markers indicates a shift of bone metabolism toward bone resorption. Animal 
      studies confirm these observations showing a reduced bone quality and stimulation 
      of bone resorption in hyperhomocysteinemic animals. In addition, homocysteine 
      (HCY) has been found to accumulate in bone tissue by collagen binding. These 
      results indicate a causal involvement of HHCY in osteoporosis. The first 
      experimental studies revealed that several pathomechanisms might be involved. 
      Cell culture studies demonstrate that high HCY and low vitamin B levels stimulate 
      osteoclasts but not osteoblasts, indicating again a shift of bone metabolism 
      toward bone resorption. In addition, HHCY seems to have adverse affects on 
      extracellular bone matrix by disturbing collagen crosslinking. Well-performed 
      large cell culture studies confirm the results obtained with exogenous HCY 
      administration. In conclusion, existing data suggest that HHCY (and possibly 
      vitamin B deficiencies) adversely affects bone quality by a stimulation of bone 
      resorption and disturbance of collagen crosslinking.
FAU - Herrmann, Wolfgang
AU  - Herrmann W
AD  - a Department of Clinical Chemistry and Laboratory Medicine, University Hospital 
      of Saarland, D-66421 Homburg, Saar, Germany. kchwher@uniklinikum-saarland.de.
FAU - Herrmann, Markus
AU  - Herrmann M
AD  - b ANZAC Research Institute, University of Sydney, 12/81 Bertram Street, 2137 
      Mortlake NSW, Australia. markusherr@aol.com.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Expert Rev Endocrinol Metab
JT  - Expert review of endocrinology & metabolism
JID - 101278293
OTO - NOTNLM
OT  - B vitamins
OT  - folate
OT  - homocysteine
OT  - intervention trial
OT  - osteoporosis
OT  - risk reduction
OT  - vitamin B
OT  - vitamin treatment
EDAT- 2008/05/01 00:00
MHDA- 2008/05/01 00:01
CRDT- 2019/02/14 06:00
PHST- 2019/02/14 06:00 [entrez]
PHST- 2008/05/01 00:00 [pubmed]
PHST- 2008/05/01 00:01 [medline]
AID - 10.1586/17446651.3.3.309 [doi]
PST - ppublish
SO  - Expert Rev Endocrinol Metab. 2008 May;3(3):309-313. doi: 
      10.1586/17446651.3.3.309.