PMID- 3075475
OWN - NLM
STAT- MEDLINE
DCOM- 19890825
LR  - 20190912
IS  - 0934-0874 (Print)
IS  - 0934-0874 (Linking)
VI  - 1
IP  - 3
DP  - 1988 Oct
TI  - HLA compatibility and different features of liver allograft rejection.
PG  - 155-60
AB  - The influence of human leukocyte antigen (HLA) on acute liver allograft rejection 
      was investigated in 48 adult patients. The diagnosis of rejection was always 
      based on the full triad of histological findings, clinical signs, and the 
      required antirejection treatment. Sixty-two percent of the patients closely 
      observed for 6 months postoperatively revealed acute rejection within the first 3 
      weeks, mostly on days 7-11. HLA compatibility was not observed to have any 
      significant influence on the incidence of acute rejection. However, different 
      histological and clinical features were revealed in conjunction with DR 
      compatibility. Patients without DR compatibility showed a type of rejection with 
      fever and increase of bilirubin, frequently associated with cholestasis and 
      cholangitis, which sometimes persisted for weeks. Patients with 1 DR 
      compatibility showed a predominant increase of transaminases, which was never 
      associated with cholangitis. The conjunction of different DR compatibilities and 
      various clinical signs may indicate possible pathways from immunological assault 
      to the clinical appearance of acute rejection. A knowledge of a patient's 
      individual compatibility and an expectation of certain rejection patterns may 
      lead to earlier and more reliable diagnosis and treatment.
FAU - Gubernatis, G
AU  - Gubernatis G
AD  - Klinik fur Abdominal- und Transplantationschirurgie, Medizinische Hochschuls, 
      Hannover, Federal Republic of Germany.
FAU - Kemnitz, J
AU  - Kemnitz J
FAU - Tusch, G
AU  - Tusch G
FAU - Pichlmayr, R
AU  - Pichlmayr R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Transpl Int
JT  - Transplant international : official journal of the European Society for Organ 
      Transplantation
JID - 8908516
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adult
MH  - *Graft Rejection
MH  - *HLA Antigens
MH  - HLA-A Antigens
MH  - HLA-B Antigens
MH  - HLA-DR Antigens
MH  - Humans
MH  - *Liver Transplantation
MH  - Time Factors
EDAT- 1988/10/01 00:00
MHDA- 1988/10/01 00:01
CRDT- 1988/10/01 00:00
PHST- 1988/10/01 00:00 [pubmed]
PHST- 1988/10/01 00:01 [medline]
PHST- 1988/10/01 00:00 [entrez]
AID - 10.1007/BF00348839 [doi]
PST - ppublish
SO  - Transpl Int. 1988 Oct;1(3):155-60. doi: 10.1007/BF00348839.