PMID- 30756347
OWN - NLM
STAT- MEDLINE
DCOM- 20200831
LR  - 20231013
IS  - 1531-135X (Electronic)
IS  - 1530-7026 (Print)
IS  - 1530-7026 (Linking)
VI  - 19
IP  - 4
DP  - 2019 Aug
TI  - Psychosis risk is associated with decreased resting-state functional connectivity 
      between the striatum and the default mode network.
PG  - 998-1011
LID - 10.3758/s13415-019-00698-z [doi]
AB  - Psychosis is linked to aberrant salience or to viewing neutral stimuli as 
      self-relevant, suggesting a possible impairment in self-relevance processing. 
      Psychosis is also associated with increased dopamine in the dorsal striatum, 
      especially the anterior caudate (Kegeles et al., 2010). Critically, the anterior 
      caudate is especially connected to (a) the cortical default mode network (DMN), 
      centrally involved in self-relevance processing, and (b) to a lesser extent, the 
      cortical frontoparietal network (FPN; Choi, Yeo, & Buckner, 2012). However, no 
      previous study has directly examined striatal-cortical DMN connectivity in 
      psychosis risk. In Study 1, we examined resting-state functional connectivity in 
      psychosis risk (n = 18) and control (n = 19) groups between (a) striatal DMN and 
      FPN subregions and (b) cortical DMN and FPN. The psychosis risk group exhibited 
      decreased connectivity between the striatal subregions and the cortical DMN. In 
      contrast, the psychosis risk group exhibited intact connectivity between the 
      striatal subregions and the cortical FPN. Additionally, recent distress was also 
      associated with decreased striatal-cortical DMN connectivity. In Study 2, to 
      determine whether the decreased striatal-cortical DMN connectivity was specific 
      to psychosis risk or was related to recent distress more generally, we examined 
      the relationship between connectivity and distress in individuals diagnosed with 
      nonpsychotic emotional distress disorders (N = 25). In contrast to Study 1, here 
      we found that distress was associated with evidence of increased 
      striatal-cortical DMN connectivity. Overall, the present results suggest that 
      decreased striatal-cortical DMN connectivity is associated with psychosis risk 
      and could contribute to aberrant salience.
FAU - Hua, Jessica P Y
AU  - Hua JPY
AD  - Department of Psychological Sciences, University of Missouri, Columbia, MO, USA.
FAU - Karcher, Nicole R
AU  - Karcher NR
AD  - Department of Psychological Sciences, University of Missouri, Columbia, MO, USA.
AD  - Department of Psychiatry, Washington University School of Medicine, St. Louis, 
      MO, USA.
FAU - Merrill, Anne M
AU  - Merrill AM
AD  - Department of Psychological Sciences, University of Missouri, Columbia, MO, USA.
FAU - O'Brien, Kathleen J
AU  - O'Brien KJ
AD  - Department of Psychological Sciences, University of Missouri, Columbia, MO, USA.
AD  - Department of Psychiatry, Washington University School of Medicine, St. Louis, 
      MO, USA.
FAU - Straub, Kelsey T
AU  - Straub KT
AD  - Department of Psychological Sciences, University of Missouri, Columbia, MO, USA.
FAU - Trull, Timothy J
AU  - Trull TJ
AD  - Department of Psychological Sciences, University of Missouri, Columbia, MO, USA.
FAU - Kerns, John G
AU  - Kerns JG
AD  - Department of Psychological Sciences, University of Missouri, Columbia, MO, USA. 
      kernsj@missouri.edu.
LA  - eng
GR  - R21 MH100359/MH/NIMH NIH HHS/United States
GR  - T32 MH014677/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cogn Affect Behav Neurosci
JT  - Cognitive, affective & behavioral neuroscience
JID - 101083946
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Caudate Nucleus/diagnostic imaging/*physiology
MH  - Cerebral Cortex/diagnostic imaging/*physiology
MH  - *Connectome
MH  - *Ego
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Nerve Net/diagnostic imaging/*physiology
MH  - Personality/*physiology
MH  - Psychotic Disorders/diagnostic imaging/*physiopathology
MH  - Risk
MH  - Schizotypal Personality Disorder/diagnostic imaging/*physiopathology
MH  - Young Adult
PMC - PMC6690819
MID - NIHMS1521496
OTO - NOTNLM
OT  - Attenuated psychotic symptoms
OT  - Corticostriatal loops
OT  - Dorsal caudate
OT  - Positive schizotypy
OT  - Temporal lobe
EDAT- 2019/02/14 06:00
MHDA- 2020/09/01 06:00
PMCR- 2020/08/01
CRDT- 2019/02/14 06:00
PHST- 2019/02/14 06:00 [pubmed]
PHST- 2020/09/01 06:00 [medline]
PHST- 2019/02/14 06:00 [entrez]
PHST- 2020/08/01 00:00 [pmc-release]
AID - 10.3758/s13415-019-00698-z [pii]
AID - 10.3758/s13415-019-00698-z [doi]
PST - ppublish
SO  - Cogn Affect Behav Neurosci. 2019 Aug;19(4):998-1011. doi: 
      10.3758/s13415-019-00698-z.