PMID- 30756471
OWN - NLM
STAT- MEDLINE
DCOM- 20191202
LR  - 20221207
IS  - 1751-2980 (Electronic)
IS  - 1751-2972 (Linking)
VI  - 20
IP  - 4
DP  - 2019 Apr
TI  - Circulating miR-29b positively correlates with non-alcoholic fatty liver disease 
      in a Chinese population.
PG  - 189-195
LID - 10.1111/1751-2980.12716 [doi]
AB  - OBJECTIVE: Early screening of non-alcoholic fatty liver disease (NAFLD) is of 
      great significance for the early detection and intervention in NAFLD. MicroRNAs 
      (miRNAs) are important regulators of metabolic diseases including NAFLD. The aim 
      of this study was to investigate the association of serum miR-29a-c with NAFLD in 
      a Chinese population. METHODS: Participants were divided into four groups based 
      on the presence or absence of NAFLD and/or type 2 diabetes mellitus (T2DM). 
      Quantitative polymerase chain reaction analysis was performed to quantify serum 
      level of miR-29a-c. The association of miR-29a-c with NAFLD was evaluated. 
      RESULTS: Serum miR-29b, but not miR-29a or miR-29c, was positively associated 
      with NAFLD (odds ratio [OR] 2.04 [1.16- 3.58], P = 0.013). Additionally, age, 
      serum triglyceride and fasting plasma glucose (FPG) levels were independently 
      associated with miR-29b (beta +/- standard error [SE] = 0.004 +/- 0.002, P = 0.019 for 
      age; beta +/- SE = 0.110 +/- 0.054, P = 0.042 for triglyceride; and 
      beta +/- SE = 0.389 +/- 0.161, P = 0.016 for FPG). MiR-29b level was positively 
      correlated with intrahepatic lipid content (beta +/- SE = 6.055 +/- 2.630, P = 0.024) 
      after adjusted for age, sex, and body mass index. CONCLUSIONS: Serum miR-29b was 
      associated with intrahepatic lipid content and NAFLD in a Chinese 
      population-based study.
CI  - (c) 2019 Chinese Medical Association Shanghai Branch, Chinese Society of 
      Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University 
      School of Medicine and John Wiley & Sons Australia, Ltd.
FAU - He, Zhen
AU  - He Z
AD  - Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, 
      Shanghai Clinical Center for Diabetes, Department of Endocrinology and 
      Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 
      Shanghai, China.
FAU - Yang, Jian Jun
AU  - Yang JJ
AD  - Department of General Surgery, Shanghai Ninth People's Hospital Affiliated to 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Zhang, Rong
AU  - Zhang R
AD  - Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, 
      Shanghai Clinical Center for Diabetes, Department of Endocrinology and 
      Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 
      Shanghai, China.
FAU - Li, Hua Ting
AU  - Li HT
AD  - Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, 
      Shanghai Clinical Center for Diabetes, Department of Endocrinology and 
      Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 
      Shanghai, China.
FAU - Wu, Liang
AU  - Wu L
AD  - Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, 
      Shanghai Clinical Center for Diabetes, Department of Endocrinology and 
      Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 
      Shanghai, China.
FAU - Jiang, Feng
AU  - Jiang F
AD  - Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, 
      Shanghai Clinical Center for Diabetes, Department of Endocrinology and 
      Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 
      Shanghai, China.
FAU - Jia, Wei Ping
AU  - Jia WP
AD  - Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, 
      Shanghai Clinical Center for Diabetes, Department of Endocrinology and 
      Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 
      Shanghai, China.
FAU - Hu, Cheng
AU  - Hu C
AUID- ORCID: 0000-0003-4314-2386
AD  - Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, 
      Shanghai Clinical Center for Diabetes, Department of Endocrinology and 
      Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 
      Shanghai, China.
AD  - Department of Endocrinology and Metabolism, Institute for Metabolic Diseases, 
      Fengxian Central Hospital, Third School of Clinical Medicine, Southern Medical 
      University, Shanghai, China.
LA  - eng
GR  - 15ZH4006/Innovation Foundation of Translational Medicine of Shanghai Jiao Tong 
      University School of Medicine/
GR  - 2016YFC1304902/National Key Research and Development Project of China/
GR  - 81570713/National Natural Science Foundation of China/
GR  - National Program for Support of Top-notch Young Professionals/
GR  - Shanghai Junior Doctor Training Supporting Program/
GR  - Shanghai SJTUSM Biobank/
PT  - Journal Article
DEP - 20190403
PL  - Australia
TA  - J Dig Dis
JT  - Journal of digestive diseases
JID - 101302699
RN  - 0 (Blood Glucose)
RN  - 0 (Lipids)
RN  - 0 (MIRN29a microRNA, human)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Aged
MH  - Asian People/genetics
MH  - Blood Glucose/analysis
MH  - Female
MH  - Humans
MH  - Lipids/blood
MH  - Male
MH  - MicroRNAs/*blood
MH  - Middle Aged
MH  - Non-alcoholic Fatty Liver Disease/*blood/genetics
OTO - NOTNLM
OT  - circulating microRNA
OT  - diabetes mellitus
OT  - miR-29a, miR-29b, miR-29c, non-alcoholic fatty liver disease
EDAT- 2019/02/14 06:00
MHDA- 2019/12/04 06:00
CRDT- 2019/02/14 06:00
PHST- 2018/06/19 00:00 [received]
PHST- 2018/12/28 00:00 [revised]
PHST- 2019/02/11 00:00 [accepted]
PHST- 2019/02/14 06:00 [pubmed]
PHST- 2019/12/04 06:00 [medline]
PHST- 2019/02/14 06:00 [entrez]
AID - 10.1111/1751-2980.12716 [doi]
PST - ppublish
SO  - J Dig Dis. 2019 Apr;20(4):189-195. doi: 10.1111/1751-2980.12716. Epub 2019 Apr 3.