PMID- 30758420
OWN - NLM
STAT- MEDLINE
DCOM- 20190312
LR  - 20190312
IS  - 1806-9282 (Electronic)
IS  - 0104-4230 (Linking)
VI  - 65
IP  - 1
DP  - 2019 Jan
TI  - Diabetic regulation of subjects with type 2 diabetes mellitus is associated with 
      serum vitamin D levels.
PG  - 51-55
LID - S0104-42302019000100051 [pii]
LID - 10.1590/1806-9282.65.1.51 [doi]
AB  - OBJECTIVE: Vitamin D deficiency is not only associated with bone metabolism but 
      also with diabetes mellitus. We aimed to study the possible association between 
      serum vitamin D concentration and HbA1c level in patients with type 2 diabetes 
      mellitus (T2DM) in this retrospective report. METHODS: Patients with T2DM were 
      enrolled to the study either in regulated or non-regulated T2DM groups, according 
      to HbA1c levels. An HbA1c level of <8% was considered as relatively controlled 
      and others were considered as poorly controlled T2DM. RESULTS: Serum vitamin D 
      levels in poorly controlled T2DM subjects (9.4 (4.9-34) ng/ml) were significantly 
      lower than that of the relatively well regulated T2DM patients (13.5 (3.4-36) 
      ng/ml) (p=0.03). Vitamin D was strongly and inversely correlated with HbA1c 
      levels (r= -0.295, p=0.005). CONCLUSION: Whatever the cause or result of the 
      diabetes mellitus, it is clear that lower vitamin D is strongly associated with 
      worse diabetic regulation in T2DM subjects. Randomized controlled larger studies, 
      which research the relation between diabetic regulation and vitamin D status, are 
      needed to claim whether it could be a therapeutic target in future in diabetic 
      subjects.
FAU - Erkus, Edip
AU  - Erkus E
AUID- ORCID: 0000-0002-7821-8275
AD  - Abant Izzet Baysal University Hospital, Faculty of Medicine, Department of 
      Internal Medicine, Bolu, Turkey.
FAU - Aktas, Gulali
AU  - Aktas G
AUID- ORCID: 0000-0001-7306-5233
AD  - Abant Izzet Baysal University Hospital, Faculty of Medicine, Department of 
      Internal Medicine, Bolu, Turkey.
FAU - Kocak, M Zahid
AU  - Kocak MZ
AUID- ORCID: 0000-0003-3085-7964
AD  - Abant Izzet Baysal University Hospital, Faculty of Medicine, Department of 
      Internal Medicine, Bolu, Turkey.
FAU - Duman, Tuba T
AU  - Duman TT
AUID- ORCID: 0000-0002-3836-2125
AD  - Abant Izzet Baysal University Hospital, Faculty of Medicine, Department of 
      Internal Medicine, Bolu, Turkey.
FAU - Atak, Burcin M
AU  - Atak BM
AUID- ORCID: 0000-0003-4201-9757
AD  - Abant Izzet Baysal University Hospital, Faculty of Medicine, Department of 
      Internal Medicine, Bolu, Turkey.
FAU - Savli, Haluk
AU  - Savli H
AUID- ORCID: 0000-0002-7422-1442
AD  - Abant Izzet Baysal University Hospital, Faculty of Medicine, Department of 
      Internal Medicine, Bolu, Turkey.
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Rev Assoc Med Bras (1992)
JT  - Revista da Associacao Medica Brasileira (1992)
JID - 9308586
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 2/*blood/complications
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Vitamin D/*blood
MH  - Vitamin D Deficiency/complications/*metabolism
EDAT- 2019/02/14 06:00
MHDA- 2019/03/13 06:00
CRDT- 2019/02/14 06:00
PHST- 2018/04/22 00:00 [received]
PHST- 2018/05/27 00:00 [accepted]
PHST- 2019/02/14 06:00 [entrez]
PHST- 2019/02/14 06:00 [pubmed]
PHST- 2019/03/13 06:00 [medline]
AID - S0104-42302019000100051 [pii]
AID - 10.1590/1806-9282.65.1.51 [doi]
PST - ppublish
SO  - Rev Assoc Med Bras (1992). 2019 Jan;65(1):51-55. doi: 10.1590/1806-9282.65.1.51.