PMID- 30761498
OWN - NLM
STAT- MEDLINE
DCOM- 20190729
LR  - 20200225
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 26
IP  - 11
DP  - 2019 Apr
TI  - The hematologic effects of BTEX exposure among elderly residents in Nanjing: a 
      cross-sectional study.
PG  - 10552-10561
LID - 10.1007/s11356-019-04492-9 [doi]
AB  - Few studies have examined the effects of environmental concentrations of benzene, 
      toluene, ethylbenzene, and xylene (BTEX) on the hematologic system of residents 
      near a petrochemical complex. This study evaluated the potential effects of blood 
      BTEX concentrations on the hematologic parameters of residents in a community 
      near a petrochemical complex (contaminated group) and another community free of 
      known petrochemical pollution (control group). Volunteer residents were randomly 
      recruited. Each participant completed a questionnaire and donated blood samples 
      to evaluate blood BTEX concentrations and hematologic parameters. We found the 
      mean concentrations of blood BTEX of the contaminated group were 1.2 to 6.7 times 
      higher than the control group. Multiple hematologic parameters of participants 
      were significantly different between the two study groups. Inverse associations 
      were found for ln-transformed blood benzene concentrations with mean corpuscular 
      hemoglobin concentration (MCHC) (beta = - 2.75) and platelet counts (beta = -8.18). 
      Several weaker associations were also observed between other compounds and 
      multiple hematologic parameters. Our results suggest that the residents living 
      near petrochemical complexes have higher blood BTEX concentrations. Furthermore, 
      the increased blood BTEX levels in residents are associated with the reduction in 
      RBC counts, hemoglobin concentration, hematocrit, MCHC, and platelet counts. This 
      study provided particularly important information for the health risk assessment 
      of residents living near petrochemical complexes.
FAU - Chen, Qi
AU  - Chen Q
AD  - Jiangsu Provincial Center for Disease Control and Prevention, Jiangsu, Road 172, 
      210009, Nanjing, People's Republic of China.
FAU - Sun, Hong
AU  - Sun H
AD  - Jiangsu Provincial Center for Disease Control and Prevention, Jiangsu, Road 172, 
      210009, Nanjing, People's Republic of China.
FAU - Zhang, Jiayao
AU  - Zhang J
AD  - Nanjing Medical University, Longmian Road 101, Jiangning District, 210029, 
      Nanjing, People's Republic of China.
FAU - Xu, Yan
AU  - Xu Y
AD  - Jiangsu Provincial Center for Disease Control and Prevention, Jiangsu, Road 172, 
      210009, Nanjing, People's Republic of China.
FAU - Ding, Zhen
AU  - Ding Z
AD  - Jiangsu Provincial Center for Disease Control and Prevention, Jiangsu, Road 172, 
      210009, Nanjing, People's Republic of China. cqjscdc@126.com.
LA  - eng
GR  - BE2018745/Jiangsu social development project/
GR  - QNRC2016551/Key Talent Project for Medical Young Scholars of Jiangsu Province/
PT  - Journal Article
DEP - 20190214
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Benzene Derivatives)
RN  - 0 (Hemoglobins)
RN  - 0 (Xylenes)
RN  - 3FPU23BG52 (Toluene)
RN  - J64922108F (Benzene)
RN  - L5I45M5G0O (ethylbenzene)
MH  - Aged
MH  - Benzene/*analysis/toxicity
MH  - Benzene Derivatives/*blood/toxicity
MH  - Blood Cell Count
MH  - China
MH  - Cross-Sectional Studies
MH  - Environmental Exposure/*adverse effects
MH  - Female
MH  - Hematology
MH  - Hemoglobins/metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Toluene/*blood/toxicity
MH  - Xylenes/*blood/toxicity
OTO - NOTNLM
OT  - BTEX
OT  - Benzene
OT  - Blood
OT  - Hematologic parameters
OT  - Petrochemical
EDAT- 2019/02/15 06:00
MHDA- 2019/07/30 06:00
CRDT- 2019/02/15 06:00
PHST- 2018/08/27 00:00 [received]
PHST- 2019/02/05 00:00 [accepted]
PHST- 2019/02/15 06:00 [pubmed]
PHST- 2019/07/30 06:00 [medline]
PHST- 2019/02/15 06:00 [entrez]
AID - 10.1007/s11356-019-04492-9 [pii]
AID - 10.1007/s11356-019-04492-9 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2019 Apr;26(11):10552-10561. doi: 
      10.1007/s11356-019-04492-9. Epub 2019 Feb 14.