PMID- 30761725
OWN - NLM
STAT- MEDLINE
DCOM- 20200529
LR  - 20200601
IS  - 1463-1326 (Electronic)
IS  - 1462-8902 (Print)
IS  - 1462-8902 (Linking)
VI  - 21
IP  - 6
DP  - 2019 Jun
TI  - Association between uric acid, renal haemodynamics and arterial stiffness over 
      the natural history of type 1 diabetes.
PG  - 1388-1398
LID - 10.1111/dom.13665 [doi]
AB  - AIMS: To examine the relationship between normal plasma uric acid (PUA) levels, 
      renal haemodynamic function, arterial stiffness and plasma renin and aldosterone 
      over a wide range of type 1 diabetes (T1D) durations in adolescents, young adults 
      and older adults. MATERIALS AND METHODS: PUA, glomerular filtration rate (GFR), 
      effective renal plasma flow (ERPF), vascular stiffness parameters (aortic 
      augmentation index [AIx], carotid AIx, carotid femoral pulse wave velocity 
      [cfPWV]), and plasma renin and aldosterone were measured during a euglycaemic 
      clamp in people with T1D: 27 adolescents (mean +/- SD age 16.8 +/- 1.9 years), 52 
      young adults (mean +/- SD age 25.6 +/- 5.5 years) and 66 older adults (mean +/- SD age 
      65.7 +/- 7.5 years). RESULTS: PUA was highest in patients with the longest T1D 
      duration: 197 +/- 44 mumol/L in adolescents versus 264 +/- 82 mumol/L in older adults 
      (P < 0.001). Higher PUA correlated with lower GFR only in older adults, even 
      after correcting for age, glycated haemoglobin and sex (beta = -2.12 +/- 0.56; 
      P = 0.0003), but not in adolescents or young adults. Higher PUA correlated with 
      lower carotid AIx (beta = -1.90, P = 0.02) in adolescents. In contrast, PUA 
      correlated with higher cfPWV (P = 0.02) and higher plasma renin (P = 0.01) in 
      older adults with T1D. CONCLUSIONS: The relationship between higher PUA with 
      lower GFR, increased arterial stiffness and renin angiotensin aldosterone system 
      (RAAS) activation was observed only in older adults with longstanding T1D. T1D 
      duration may modify the association between PUA, renal haemodynamic function and 
      RAAS activation, leading to renal vasoconstriction and ischaemia. Further work 
      must determine whether pharmacological PUA-lowering prevents or reverses 
      injurious haemodynamic and neurohormonal sequelae of longstanding T1D, thereby 
      improving clinical outcomes.
CI  - (c) 2019 John Wiley & Sons Ltd.
FAU - Lytvyn, Yuliya
AU  - Lytvyn Y
AUID- ORCID: 0000-0003-1805-9994
AD  - Department of Medicine, Division of Nephrology, Toronto General Hospital, 
      University of Toronto, Toronto, Ontario, Canada.
FAU - Bjornstad, Petter
AU  - Bjornstad P
AUID- ORCID: 0000-0002-5160-2947
AD  - Department of Pediatrics, Division of Endocrinology, University of Colorado 
      School of Medicine, Aurora, Colorado.
AD  - Department of Medicine, Division of Nephrology, University of Colorado School of 
      Medicine.
FAU - Lovshin, Julie A
AU  - Lovshin JA
AD  - Department of Medicine, Division of Endocrinology and Metabolism, Sunnybrook 
      Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
FAU - Singh, Sunita K
AU  - Singh SK
AD  - Department of Medicine, Division of Nephrology, Toronto General Hospital, 
      University of Toronto, Toronto, Ontario, Canada.
FAU - Boulet, Genevieve
AU  - Boulet G
AD  - Department of Medicine, Division of Endocrinology and Metabolism, Sunnybrook 
      Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
FAU - Farooqi, Mohammed A
AU  - Farooqi MA
AD  - Department of Medicine, Division of Endocrinology and Metabolism, Sunnybrook 
      Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
FAU - Lai, Vesta
AU  - Lai V
AD  - Department of Medicine, Division of Nephrology, Toronto General Hospital, 
      University of Toronto, Toronto, Ontario, Canada.
FAU - Tse, Josephine
AU  - Tse J
AD  - Department of Medicine, Division of Nephrology, Toronto General Hospital, 
      University of Toronto, Toronto, Ontario, Canada.
FAU - Cham, Leslie
AU  - Cham L
AD  - Department of Medicine, Division of Nephrology, Toronto General Hospital, 
      University of Toronto, Toronto, Ontario, Canada.
FAU - Lovblom, Leif E
AU  - Lovblom LE
AD  - Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, 
      Canada.
FAU - Weisman, Alanna
AU  - Weisman A
AUID- ORCID: 0000-0003-3778-653X
AD  - Department of Medicine, Division of Endocrinology and Metabolism, Sunnybrook 
      Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
FAU - Keenan, Hillary A
AU  - Keenan HA
AD  - Research Division, Joslin Diabetes Center, Boston, Massachusetts.
FAU - Brent, Michael H
AU  - Brent MH
AD  - Department of Ophthalmology and Vision Sciences, Department of Medicine, 
      University of Toronto, Ontario, Canada.
FAU - Paul, Narinder
AU  - Paul N
AD  - Joint Department of Medical Imaging, Division of Cardiothoracic Radiology, 
      University Health Network, Toronto, Ontario, Canada.
FAU - Bril, Vera
AU  - Bril V
AD  - Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Division of 
      Neurology, Department of Medicine, University Health Network, University of 
      Toronto, Toronto, Ontario, Canada.
AD  - Department of Neuroscience Research, Institute for Research and Medical 
      Consultations, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
FAU - Advani, Andrew
AU  - Advani A
AD  - Department of Medicine, Keenan Research Centre for Biomedical Science and Li Ka 
      Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada.
FAU - Sochett, Etienne
AU  - Sochett E
AD  - Division of Pediatric Endocrinology, Department of Pediatrics, University of 
      Toronto, Toronto, Ontario, Canada.
FAU - Perkins, Bruce A
AU  - Perkins BA
AD  - Department of Medicine, Division of Endocrinology and Metabolism, Sunnybrook 
      Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
FAU - Cherney, David Z I
AU  - Cherney DZI
AD  - Department of Medicine, Division of Nephrology, Toronto General Hospital, 
      University of Toronto, Toronto, Ontario, Canada.
LA  - eng
GR  - T32 DK063687/DK/NIDDK NIH HHS/United States
GR  - K23 DK116720/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20190328
PL  - England
TA  - Diabetes Obes Metab
JT  - Diabetes, obesity & metabolism
JID - 100883645
RN  - 268B43MJ25 (Uric Acid)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - *Diabetes Mellitus, Type 1/blood/epidemiology/physiopathology
MH  - Female
MH  - Glomerular Filtration Rate/physiology
MH  - Hemodynamics/physiology
MH  - Humans
MH  - *Kidney/blood supply/physiology
MH  - Male
MH  - Middle Aged
MH  - Pulse Wave Analysis
MH  - Retrospective Studies
MH  - Uric Acid/*blood
MH  - Vascular Stiffness/*physiology
MH  - Young Adult
PMC - PMC6504604
MID - NIHMS1012996
OTO - NOTNLM
OT  - RAAS
OT  - arterial stiffness
OT  - plasma uric acid
OT  - renal function
OT  - type 1 diabetes
EDAT- 2019/02/15 06:00
MHDA- 2020/05/30 06:00
PMCR- 2020/06/01
CRDT- 2019/02/15 06:00
PHST- 2018/11/02 00:00 [received]
PHST- 2019/02/03 00:00 [revised]
PHST- 2019/02/10 00:00 [accepted]
PHST- 2019/02/15 06:00 [pubmed]
PHST- 2020/05/30 06:00 [medline]
PHST- 2019/02/15 06:00 [entrez]
PHST- 2020/06/01 00:00 [pmc-release]
AID - 10.1111/dom.13665 [doi]
PST - ppublish
SO  - Diabetes Obes Metab. 2019 Jun;21(6):1388-1398. doi: 10.1111/dom.13665. Epub 2019 
      Mar 28.