PMID- 30762914
OWN - NLM
STAT- MEDLINE
DCOM- 20191216
LR  - 20191217
IS  - 1872-8081 (Electronic)
IS  - 0951-6433 (Linking)
VI  - 45
IP  - 3
DP  - 2019 May
TI  - Gut microbiota signatures and lipids metabolism profiles by exposure to polyene 
      phosphatidylcholine.
PG  - 439-449
LID - 10.1002/biof.1495 [doi]
AB  - The aim of the study was to address the causality links and identify specific 
      features of the gut microbiota signatures contributing to host lipids metabolism 
      in the presence or absence of polyene phosphatidylcholine (PPC) administration, 
      and evaluate potential risk of PPC consumption. About 20 C57BL/6J mice were 
      randomly allocated into two groups, normal diet group (CK) and PPC administration 
      group (205.2 mg/kg). Compared with CK group, the contents of unsaturated fatty 
      acids were increased and the saturated fatty acids were decreased in PPC group. 
      The content of free fatty acids (FFA) and lipopolysaccharides (LPS) were 
      significantly decreased (P < 0.05), and expression of carnitine 
      palmitoyltransferase 1A (CPT1A), cluster of differentiation 36 (CD36), liver 
      fatty acid binding protein (L-FABP), fatty acid transport protein 5 (FATP5), and 
      fatty acid synthase (FASN) were significantly decreased in the mRNA and protein 
      levels after treated by PPC (P < 0.05, P < 0.01). Also, we found that acetic acid 
      in feces was significantly increased after consumption of PPC (P < 0.05). After 
      PPC administration the relative abundances of Firmicutes and Clostridia were 
      increased within the phylum level and the class level, respectively. Microbial 
      abundances in genus level were dominated by Lachnospiraceae and 
      Lachnospiraceae_NK4A136_group, whereas the proportion of sequences assigned to 
      Bacteroidetes within the phylum level, class Bacteroidias and Mollicutes, order 
      Anaeroplasmatalesl, genus Bacteroidales_S24-7_group were decreased in metagenomes 
      of treated group with PPC and did not significantly influence on the accumulation 
      of trimethylamine-N-oxide (TMAO). This study revealed that intake of PPC could 
      regulate the gut microbiota signatures and lipids metabolism in mice without TMAO 
      accumulations. (c) 2019 BioFactors, 45(3):439-449, 2019.
CI  - (c) 2019 International Union of Biochemistry and Molecular Biology.
FAU - Yu, Haining
AU  - Yu H
AUID- ORCID: 0000-0003-3429-8557
AD  - College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 
      China.
FAU - Yu, Zhen
AU  - Yu Z
AD  - College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 
      China.
FAU - Huang, Haiyong
AU  - Huang H
AD  - College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 
      China.
FAU - Li, Peng
AU  - Li P
AD  - Department of Geratology, The Third People's Hospital of Hangzhou, Hangzhou, 
      China.
FAU - Tang, Qiu
AU  - Tang Q
AD  - Department of Oncology, The Central Hospital of Wuhan, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China.
FAU - Wang, Xique
AU  - Wang X
AD  - Xianyang Rainbow Hospital, Xianyang, China.
FAU - Shen, Shengrong
AU  - Shen S
AD  - Department of Food Science & Nutrition, Zhejiang University, Hangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20190214
PL  - Netherlands
TA  - Biofactors
JT  - BioFactors (Oxford, England)
JID - 8807441
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Phosphatidylcholines)
RN  - 0 (polyene phosphatidylcholine)
SB  - IM
MH  - Animals
MH  - Fatty Acids, Nonesterified/*metabolism
MH  - Female
MH  - Gastrointestinal Microbiome/*drug effects
MH  - Lipid Metabolism/*drug effects
MH  - Lipopolysaccharides/blood
MH  - Liver/drug effects/*metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Phosphatidylcholines/*pharmacology
OTO - NOTNLM
OT  - fatty acid metabolism enzymes
OT  - gut microbiota
OT  - lipids metabolism
OT  - lipopolysaccharides
OT  - polyene phosphatidylcholine
OT  - short chain fatty acids
OT  - trimethylamine-N-oxide
EDAT- 2019/02/15 06:00
MHDA- 2019/12/18 06:00
CRDT- 2019/02/15 06:00
PHST- 2018/11/24 00:00 [received]
PHST- 2019/01/18 00:00 [revised]
PHST- 2019/01/20 00:00 [accepted]
PHST- 2019/02/15 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2019/02/15 06:00 [entrez]
AID - 10.1002/biof.1495 [doi]
PST - ppublish
SO  - Biofactors. 2019 May;45(3):439-449. doi: 10.1002/biof.1495. Epub 2019 Feb 14.