PMID- 30763158
OWN - NLM
STAT- MEDLINE
DCOM- 20200623
LR  - 20231011
IS  - 1522-1601 (Electronic)
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 126
IP  - 4
DP  - 2019 Apr 1
TI  - Age-related differences in water and sodium handling after commercial hydration 
      beverage ingestion.
PG  - 1042-1048
LID - 10.1152/japplphysiol.01094.2018 [doi]
AB  - Aging is associated with altered water, electrolyte, and glucose handling. 
      Alternative beverages to those containing carbohydrate (CHO) should be considered 
      for older adults. We hypothesized that reduced sodium (CNa(+)) and/or water 
      (CH(2)O) clearance would underlie greater beverage retention in older compared 
      with young adults, secondary to reduced glomerular filtration rate (GFR). We 
      further hypothesized that amino acid (AA)- and CHO-based beverages would promote 
      retention better than water. Over five visits, 12 young (23 +/- 3 yr; 7 men, 5 
      women) and 12 older (67 +/- 6 yr; 5 men, 7 women) subjects consumed 1 liter of 
      distilled water or beverages with 6% CHO, 0.46 g/l Na(+) [Gatorade (GAT)]; 2.5% 
      CHO, 0.74 g/l Na(+) [Pedialyte (PED)]; 5 AA, 1.04 g/l Na(+) [enterade (ENT)-5]; 
      or 8 AA, 1.38 g/l Na(+) (ENT-8) over 30 min. Blood and urine were collected every 
      hour for 4 h after ingestion; retention, CH(2)O, and CNa(+) were calculated at 2 
      and 4 h. Additional calculations adjusted CH(2)O and CNa(+) for estimated GFR 
      (eGFR). Water yielded the lowest retention in both groups ( P </= 0.02). Retention 
      was higher in older vs. young adults except for ENT-8 at 4 h ( P = 0.73). CH(2)O 
      was higher for older vs. young adults for GAT at 2 h ( P < 0.01) and GAT and PED 
      at 4 h ( P < 0.01) after ingestion but was otherwise similar between groups. 
      CNa(+) was lower in older vs. young adults except for ENT-8 ( P >/= 0.19). 
      Adjusting for eGFR resulted in higher CH(2)O for all beverages in older vs. young 
      adults ( P < 0.05) but did not influence CNa(+). Older adults may better retain 
      beverages with less Na(+) than young adults because of reduced CNa(+). AA- and 
      CHO-based electrolyte-rich beverages may similarly promote beverage retention. 
      NEW & NOTEWORTHY Commercially available amino acid (AA)-containing beverages may 
      provide an alternative to traditional carbohydrate (CHO)-containing beverages, 
      particularly for older adults with attenuated water, electrolyte, and glucose 
      handling. We compared beverage retention and free water and sodium clearance 
      between young and older adults after ingestion of water, two CHO-based beverages, 
      and two AA-based beverages. Our data suggest that older adults better retain 
      beverages with less sodium compared with young adults and that AA-based and 
      CHO-based electrolyte-containing beverages similarly promote retention.
FAU - Wolf, S Tony
AU  - Wolf ST
AD  - Department of Kinesiology, The Pennsylvania State University , University Park, 
      Pennsylvania.
FAU - Stanhewicz, Anna E
AU  - Stanhewicz AE
AD  - Department of Kinesiology, The Pennsylvania State University , University Park, 
      Pennsylvania.
FAU - Clarke, Megan M
AU  - Clarke MM
AD  - Department of Kinesiology, The Pennsylvania State University , University Park, 
      Pennsylvania.
FAU - Cheuvront, Samuel N
AU  - Cheuvront SN
AD  - US Army Research Institute of Environmental Medicine , Natick, Massachusetts.
FAU - Kenefick, Robert W
AU  - Kenefick RW
AD  - US Army Research Institute of Environmental Medicine , Natick, Massachusetts.
FAU - Kenney, W Larry
AU  - Kenney WL
AD  - Department of Kinesiology, The Pennsylvania State University , University Park, 
      Pennsylvania.
LA  - eng
GR  - T32 AG049676/AG/NIA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20190214
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Electrolytes)
RN  - 0 (Ions)
RN  - 059QF0KO0R (Water)
RN  - 9NEZ333N27 (Sodium)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Beverages
MH  - Blood Glucose/metabolism
MH  - Dehydration/physiopathology
MH  - Dietary Carbohydrates/metabolism
MH  - Dietary Supplements
MH  - Eating/*physiology
MH  - Electrolytes/*metabolism
MH  - Exercise/physiology
MH  - Female
MH  - Glomerular Filtration Rate/physiology
MH  - Glucose/metabolism
MH  - Humans
MH  - Ions/metabolism
MH  - Male
MH  - Sodium/*metabolism
MH  - Water/*metabolism
MH  - Water-Electrolyte Balance/*physiology
MH  - Young Adult
PMC - PMC6485687
OTO - NOTNLM
OT  - aging
OT  - beverage retention
OT  - hydration
COIS- This study was partially funded by an unrestricted gift from Entrinsic Health 
      Solutions, Inc.
EDAT- 2019/02/15 06:00
MHDA- 2020/06/24 06:00
PMCR- 2020/04/01
CRDT- 2019/02/15 06:00
PHST- 2019/02/15 06:00 [pubmed]
PHST- 2020/06/24 06:00 [medline]
PHST- 2019/02/15 06:00 [entrez]
PHST- 2020/04/01 00:00 [pmc-release]
AID - JAPPL-01094-2018 [pii]
AID - 10.1152/japplphysiol.01094.2018 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 2019 Apr 1;126(4):1042-1048. doi: 
      10.1152/japplphysiol.01094.2018. Epub 2019 Feb 14.