PMID- 30763715
OWN - NLM
STAT- MEDLINE
DCOM- 20191230
LR  - 20240214
IS  - 1872-7980 (Electronic)
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 448
DP  - 2019 Apr 28
TI  - Essential role of JunD in cell proliferation is mediated via MYC signaling in 
      prostate cancer cells.
PG  - 155-167
LID - S0304-3835(19)30077-1 [pii]
LID - 10.1016/j.canlet.2019.02.005 [doi]
AB  - JunD, a member of the AP-1 family, is essential for cell proliferation in 
      prostate cancer (PCa) cells. We recently demonstrated that JunD knock-down (KD) 
      in PCa cells results in cell cycle arrest in G(1)-phase concomitant with a 
      decrease in cyclin D1, Ki67, and c-MYC, but an increase in p21 levels. 
      Furthermore, the over-expression of JunD significantly increased proliferation 
      suggesting JunD regulation of genes required for cell cycle progression. Here, 
      employing gene expression profiling, quantitative proteomics, and validation 
      approaches, we demonstrate that JunD KD is associated with distinct gene and 
      protein expression patterns. Comparative integrative analysis by Ingenuity 
      Pathway Analysis (IPA) identified 1) cell cycle control/regulation as the top 
      canonical pathway whose members exhibited a significant decrease in their 
      expression following JunD KD including PRDX3, PEA15, KIF2C, and CDK2, and 2) JunD 
      dependent genes are associated with cell proliferation, with MYC as the critical 
      downstream regulator. Conversely, JunD over-expression induced the expression of 
      the above genes including c-MYC. We conclude that JunD is a crucial regulator of 
      cell cycle progression and inhibiting its target genes may be an effective 
      approach to block prostate carcinogenesis.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Elliott, Bethtrice
AU  - Elliott B
AD  - Center for Cancer Research and Therapeutic Development, Clark Atlanta University, 
      223 James P. Brawley Dr. SW, Atlanta, GA, 30314, USA.
FAU - Millena, Ana Cecilia
AU  - Millena AC
AD  - Center for Cancer Research and Therapeutic Development, Clark Atlanta University, 
      223 James P. Brawley Dr. SW, Atlanta, GA, 30314, USA.
FAU - Matyunina, Lilya
AU  - Matyunina L
AD  - Integrated Cancer Research Center, School of Biological Sciences, Parker H. Petit 
      Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 
      Ferst Drive, Atlanta, GA, 30309, USA.
FAU - Zhang, Mengnan
AU  - Zhang M
AD  - Integrated Cancer Research Center, School of Biological Sciences, Parker H. Petit 
      Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 
      Ferst Drive, Atlanta, GA, 30309, USA.
FAU - Zou, Jin
AU  - Zou J
AD  - Center for Cancer Research and Therapeutic Development, Clark Atlanta University, 
      223 James P. Brawley Dr. SW, Atlanta, GA, 30314, USA.
FAU - Wang, Guangdi
AU  - Wang G
AD  - Department of Chemistry, RCMI Cancer Research Center, Xavier University, 1 Drexel 
      Drive, New Orleans, LA, 70125, USA.
FAU - Zhang, Qiang
AU  - Zhang Q
AD  - Department of Chemistry, RCMI Cancer Research Center, Xavier University, 1 Drexel 
      Drive, New Orleans, LA, 70125, USA.
FAU - Bowen, Nathan
AU  - Bowen N
AD  - Center for Cancer Research and Therapeutic Development, Clark Atlanta University, 
      223 James P. Brawley Dr. SW, Atlanta, GA, 30314, USA.
FAU - Eaton, Vanessa
AU  - Eaton V
AD  - Center for Cancer Research and Therapeutic Development, Clark Atlanta University, 
      223 James P. Brawley Dr. SW, Atlanta, GA, 30314, USA.
FAU - Webb, Gabrielle
AU  - Webb G
AD  - Center for Cancer Research and Therapeutic Development, Clark Atlanta University, 
      223 James P. Brawley Dr. SW, Atlanta, GA, 30314, USA.
FAU - Thompson, Shadyra
AU  - Thompson S
AD  - Center for Cancer Research and Therapeutic Development, Clark Atlanta University, 
      223 James P. Brawley Dr. SW, Atlanta, GA, 30314, USA.
FAU - McDonald, John
AU  - McDonald J
AD  - Integrated Cancer Research Center, School of Biological Sciences, Parker H. Petit 
      Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 
      Ferst Drive, Atlanta, GA, 30309, USA.
FAU - Khan, Shafiq
AU  - Khan S
AD  - Center for Cancer Research and Therapeutic Development, Clark Atlanta University, 
      223 James P. Brawley Dr. SW, Atlanta, GA, 30314, USA. Electronic address: 
      skhan@cau.edu.
LA  - eng
GR  - G12 MD007590/MD/NIMHD NIH HHS/United States
GR  - P20 MD002285/MD/NIMHD NIH HHS/United States
GR  - R25 GM060566/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20190211
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (Proto-Oncogene Proteins c-jun)
RN  - 0 (Proto-Oncogene Proteins c-myc)
SB  - IM
MH  - Cell Cycle/physiology
MH  - Cell Line, Tumor
MH  - Cell Proliferation/*physiology
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Male
MH  - Microarray Analysis
MH  - Prostatic Neoplasms/*metabolism
MH  - Proto-Oncogene Proteins c-jun/*physiology
MH  - Proto-Oncogene Proteins c-myc/*physiology
MH  - Signal Transduction/physiology
PMC - PMC6414252
MID - NIHMS1522264
OTO - NOTNLM
OT  - Cancer initiation
OT  - Cell cycle regulation
OT  - JunD
OT  - Prostate cancer
OT  - c-MYC
COIS- Conflicts of interest The authors declare no conflict of interest.
EDAT- 2019/02/15 06:00
MHDA- 2019/12/31 06:00
PMCR- 2020/04/28
CRDT- 2019/02/15 06:00
PHST- 2018/08/04 00:00 [received]
PHST- 2019/02/04 00:00 [revised]
PHST- 2019/02/05 00:00 [accepted]
PHST- 2019/02/15 06:00 [pubmed]
PHST- 2019/12/31 06:00 [medline]
PHST- 2019/02/15 06:00 [entrez]
PHST- 2020/04/28 00:00 [pmc-release]
AID - S0304-3835(19)30077-1 [pii]
AID - 10.1016/j.canlet.2019.02.005 [doi]
PST - ppublish
SO  - Cancer Lett. 2019 Apr 28;448:155-167. doi: 10.1016/j.canlet.2019.02.005. Epub 
      2019 Feb 11.