PMID- 30764842 OWN - NLM STAT- MEDLINE DCOM- 20190320 LR - 20200225 IS - 1477-7525 (Electronic) IS - 1477-7525 (Linking) VI - 17 IP - 1 DP - 2019 Feb 14 TI - Responsiveness and minimal clinically important difference of the Minnesota living with heart failure questionnaire. PG - 36 LID - 10.1186/s12955-019-1104-2 [doi] LID - 36 AB - BACKGROUND: The Minnesota Living with Heart Failure Questionnaire (MLHFQ) is one of the most widely used health-related quality of life questionnaires for patients with heart failure (HF). The objective of the present study was to explore the responsiveness of the MLHFQ by estimating the minimal detectable change (MDC) and the minimal clinically important difference (MCID) in Spain. METHODS: Patients hospitalized for HF in the participating hospitals completed the MLHFQ at baseline and 6 months, plus anchor questions at 6 months. To study responsiveness, patients were classified as having "improved", remained "the same" or "worsened", using anchor questions. We used the standardized effect size (SES), and standardized response mean (SRM) to measure the magnitude of the changes scores and calculate the MDC and MCID. RESULTS: Overall, 1211 patients completed the baseline and follow-up questionnaires 6 months after discharge. The mean changes in all MLHFQ domains followed a trend (P < 0.0001) with larger gains in quality of life among patients classified as "improved", smaller gains among those classified as "the same", and losses among those classified as "worsened". The SES and SRM responsiveness parameters in the "improved" group were >/= 0.80 on nearly all scales. Among patients classified as "worsened", effect sizes were < 0.40, while among patients classified as "the same", the values ranged from 0.24 to 0.52. The MDC ranged from 7.27 to 16.96. The MCID based on patients whose response to the anchor question was "somewhat better", ranged from 3.59 to 19.14 points. CONCLUSIONS: All of these results suggest that all domains of the MLHFQ have a good sensitivity to change in the population studied. FAU - Gonzalez-Saenz de Tejada, M AU - Gonzalez-Saenz de Tejada M AD - Research Unit, Basurto University Hospital, Jado 4th floor, Avda Montevideo 18, 48013, Bilbao, Vizcaya, Spain. marta.gonzalezsaenzdetejada@osakidetza.eus. AD - Red de Investigacion en Servicios de Salud en Enfermedades Cronicas (REDISSEC), Madrid, Spain. marta.gonzalezsaenzdetejada@osakidetza.eus. FAU - Bilbao, A AU - Bilbao A AD - Research Unit, Basurto University Hospital, Jado 4th floor, Avda Montevideo 18, 48013, Bilbao, Vizcaya, Spain. AD - Red de Investigacion en Servicios de Salud en Enfermedades Cronicas (REDISSEC), Madrid, Spain. FAU - Ansola, L AU - Ansola L AD - Research Unit, Basurto University Hospital, Jado 4th floor, Avda Montevideo 18, 48013, Bilbao, Vizcaya, Spain. FAU - Quiros, R AU - Quiros R AD - Red de Investigacion en Servicios de Salud en Enfermedades Cronicas (REDISSEC), Madrid, Spain. AD - Hospital Costa del Sol, Carretera Nacional 340, km 186, Marbella, Malaga, Spain. FAU - Garcia-Perez, L AU - Garcia-Perez L AD - Red de Investigacion en Servicios de Salud en Enfermedades Cronicas (REDISSEC), Madrid, Spain. AD - Planning and Evaluation Service, Canary Islands Health Service, Camino Candelaria, 44 C.S. San Isidro-El Chorrillo, 38109, El Rosario, Tenerife, Spain. FAU - Navarro, G AU - Navarro G AD - Epidemiology Unit, Hospital Universitari, Parc Tauli 1, 08208, Sabadell, Barcelona, Spain. FAU - Escobar, A AU - Escobar A AD - Research Unit, Basurto University Hospital, Jado 4th floor, Avda Montevideo 18, 48013, Bilbao, Vizcaya, Spain. AD - Red de Investigacion en Servicios de Salud en Enfermedades Cronicas (REDISSEC), Madrid, Spain. LA - eng GR - PS09/01129/Instituto de Salud Carlos III/ GR - PS09/00865/Instituto de Salud Carlos III/ GR - PS09/01053/Instituto de Salud Carlos III/ GR - PS09/01770/Instituto de Salud Carlos III/ GR - 2008111017/Department of Health of Basque Government/ PT - Journal Article PT - Validation Study DEP - 20190214 PL - England TA - Health Qual Life Outcomes JT - Health and quality of life outcomes JID - 101153626 SB - IM MH - Adult MH - Aged MH - Female MH - Heart Failure/*psychology MH - Humans MH - Male MH - Middle Aged MH - *Minimal Clinically Important Difference MH - Minnesota MH - *Quality of Life MH - Spain MH - Surveys and Questionnaires/standards PMC - PMC6376687 OTO - NOTNLM OT - Health-related quality of life OT - Heart failure OT - Minimal clinically important difference OT - Minnesota living with heart failure questionnaire OT - Psychometric properties OT - Responsiveness COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This study received the approval of the following Ethics Committees for Clinical Research: Hospital Universitario de Basurto (22.08), Hospital Costa del Sol, Hospital Universitar Parc Tauli, and Hospital Universitario Nuestra Senora de Candelaria (09/09). Consent to participate was obtained from all individual participants included in the study. CONSENT FOR PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER'S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. EDAT- 2019/02/16 06:00 MHDA- 2019/03/21 06:00 PMCR- 2019/02/14 CRDT- 2019/02/16 06:00 PHST- 2018/09/06 00:00 [received] PHST- 2019/02/07 00:00 [accepted] PHST- 2019/02/16 06:00 [entrez] PHST- 2019/02/16 06:00 [pubmed] PHST- 2019/03/21 06:00 [medline] PHST- 2019/02/14 00:00 [pmc-release] AID - 10.1186/s12955-019-1104-2 [pii] AID - 1104 [pii] AID - 10.1186/s12955-019-1104-2 [doi] PST - epublish SO - Health Qual Life Outcomes. 2019 Feb 14;17(1):36. doi: 10.1186/s12955-019-1104-2.