PMID- 30767728
OWN - NLM
STAT- MEDLINE
DCOM- 20200406
LR  - 20200408
IS  - 1557-8100 (Electronic)
IS  - 1536-2310 (Linking)
VI  - 23
IP  - 2
DP  - 2019 Feb
TI  - Epigenomics-Guided Drug Development: Recent Advances in Solving the Cancer 
      Treatment "jigsaw puzzle".
PG  - 70-85
LID - 10.1089/omi.2018.0206 [doi]
AB  - The human epigenome plays a key role in determining cellular identity and 
      eventually function. Drug discovery undertakings have focused mainly on the role 
      of genomics in carcinogenesis, with the focus turning to the epigenome recently. 
      Drugs targeting DNA and histone modifications are under development with some 
      such as 5-azacytidine, decitabine, vorinostat, and panobinostat already approved 
      by the Food and Drug Administration (FDA) and the European Medicines Agency 
      (EMA). This expert review offers a critical analysis of the epigenomics-guided 
      drug discovery and development and the opportunities and challenges for the next 
      decade. Importantly, the coupling of epigenetic editing techniques, such as 
      clustered regularly interspersed short palindromic repeat 
      (CRISPR)-CRISPR-associated protein-9 (Cas9) and APOBEC-coupled epigenetic 
      sequencing (ACE-seq) with epigenetic drug screens, will allow the identification 
      of small-molecule inhibitors or drugs able to reverse epigenetic changes 
      responsible for many diseases. In addition, concrete and sustainable innovation 
      in cancer treatment ought to integrate epigenome targeting drugs with classic 
      therapies such as chemotherapy and immunotherapy.
FAU - Dzobo, Kevin
AU  - Dzobo K
AD  - 1 International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape 
      Town Component, Cape Town, South Africa.
AD  - 2 Division of Medical Biochemistry and Institute of Infectious Disease and 
      Molecular Medicine, Department of Integrative Biomedical Sciences, Faculty of 
      Health Sciences, University of Cape Town, Cape Town, South Africa.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - OMICS
JT  - Omics : a journal of integrative biology
JID - 101131135
SB  - IM
MH  - Clustered Regularly Interspaced Short Palindromic Repeats/genetics
MH  - DNA Methylation/genetics
MH  - Epigenesis, Genetic/*genetics
MH  - Epigenomics/*methods
MH  - Humans
OTO - NOTNLM
OT  - CRISPR
OT  - clinical trials
OT  - drug development
OT  - drug discovery
OT  - drugs
OT  - epigenetics
OT  - epigenomics
OT  - functional genomics
EDAT- 2019/02/16 06:00
MHDA- 2020/04/09 06:00
CRDT- 2019/02/16 06:00
PHST- 2019/02/16 06:00 [entrez]
PHST- 2019/02/16 06:00 [pubmed]
PHST- 2020/04/09 06:00 [medline]
AID - 10.1089/omi.2018.0206 [doi]
PST - ppublish
SO  - OMICS. 2019 Feb;23(2):70-85. doi: 10.1089/omi.2018.0206.