PMID- 30767866
OWN - NLM
STAT- MEDLINE
DCOM- 20191008
LR  - 20191008
IS  - 0392-856X (Print)
IS  - 0392-856X (Linking)
VI  - 37
IP  - 5
DP  - 2019 Sep-Oct
TI  - Clinical features of thirty-two patients with anti-melanoma 
      differentiation-associated gene 5 antibodies.
PG  - 803-807
AB  - OBJECTIVES: To investigate the clinical characteristics of patients positive for 
      anti-melanoma differentiation-associated gene 5 (MDA5) antibodies, and to analyse 
      the potential pathogenesis of anti-MDA5 antibodies. METHODS: The clinical 
      manifestations, serological tests, imaging features, treatments, and prognoses of 
      32 anti-MDA5 antibody-positive patients diagnosed in the Rheumatology and 
      Immunology Department of the Second Affiliated Hospital of Chongqing Medical 
      University from September 2015 to August 2018 were analysed. RESULTS: Of the 32 
      anti-MDA5 antibody-positive patients, eleven patients were clinically diagnosed 
      with interstitial pneumonia with autoimmune features (IPAF), ten patients were 
      diagnosed with clinically amyopathic dermatomyositis (CADM), six patients were 
      diagnosed with dermatomyositis (DM) and five patients were diagnosed with 
      anti-synthetase syndrome (ASS). Thirty patients had various degrees of pulmonary 
      interstitial changes. The incidence of mortality, subcutaneous emphysema, 
      hoarseness and dysphagia in patients who were positive for both anti-MDA5 and 
      anti-Ro52 antibodies was significantly higher than in patients positive for only 
      anti-MDA5 antibodies. The anti-MDA5 antibody-positive IPAF patients had a very 
      poor prognosis, and mortality in these patients was as high as 54.55%. 
      CONCLUSIONS: Anti-MDA5 antibodies are closely related to interstitial lung 
      disease (ILD). The presence of both anti-MDA5 and anti-Ro52 antibodies indicates 
      poor prognosis.
FAU - Huang, Wenhan
AU  - Huang W
AD  - Department of Rheumatology and Immunology of the Second Affiliated Hospital of 
      Chongqing Medical University, Chongqing, China.
FAU - Ren, Feifeng
AU  - Ren F
AD  - Department of Rheumatology and Immunology of the Second Affiliated Hospital of 
      Chongqing Medical University, Chongqing, China.
FAU - Wang, Qian
AU  - Wang Q
AD  - Department of Rheumatology and Immunology, Peking Union Medical College Hospital, 
      Beijing, China.
FAU - Luo, Lei
AU  - Luo L
AD  - Department of Rheumatology and Immunology of the Second Affiliated Hospital of 
      Chongqing Medical University, Chongqing, China.
FAU - Zhou, Jun
AU  - Zhou J
AD  - Department of Rheumatology and Immunology of the Second Affiliated Hospital of 
      Chongqing Medical University, Chongqing, China.
FAU - Huang, Dongmei
AU  - Huang D
AD  - Department of Rheumatology and Immunology of the Second Affiliated Hospital of 
      Chongqing Medical University, Chongqing, China.
FAU - Pan, Zhuma
AU  - Pan Z
AD  - Department of Endocrinology and Nephrology, The Seven People's Hospital, 
      Chongqing, China.
FAU - Tang, Lin
AU  - Tang L
AD  - Department of Rheumatology and Immunology of the Second Affiliated Hospital of 
      Chongqing Medical University, Chongqing, China. hopetang@163.com.
LA  - eng
PT  - Journal Article
DEP - 20190211
PL  - Italy
TA  - Clin Exp Rheumatol
JT  - Clinical and experimental rheumatology
JID - 8308521
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - EC 3.6.1.- (IFIH1 protein, human)
RN  - EC 3.6.4.13 (Interferon-Induced Helicase, IFIH1)
SB  - IM
MH  - *Autoantibodies/blood
MH  - Biomarkers
MH  - Dermatomyositis/*immunology
MH  - Disease Progression
MH  - Humans
MH  - Interferon-Induced Helicase, IFIH1/*immunology
MH  - Lung Diseases, Interstitial/*immunology
MH  - Retrospective Studies
EDAT- 2019/02/16 06:00
MHDA- 2019/10/09 06:00
CRDT- 2019/02/16 06:00
PHST- 2018/09/15 00:00 [received]
PHST- 2018/12/03 00:00 [accepted]
PHST- 2019/02/16 06:00 [pubmed]
PHST- 2019/10/09 06:00 [medline]
PHST- 2019/02/16 06:00 [entrez]
AID - 13442 [pii]
PST - ppublish
SO  - Clin Exp Rheumatol. 2019 Sep-Oct;37(5):803-807. Epub 2019 Feb 11.