PMID- 30771583
OWN - NLM
STAT- MEDLINE
DCOM- 20190909
LR  - 20190909
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 177
DP  - 2019 May 1
TI  - Polymeric prodrug microspheres with tumor intracellular microenvironment 
      bioreducible degradation, pH-triggered "off-on" fluorescence and drug release for 
      precise imaging-guided diagnosis and chemotherapy.
PG  - 313-320
LID - S0927-7765(19)30076-1 [pii]
LID - 10.1016/j.colsurfb.2019.02.002 [doi]
AB  - Theranostic nanoplatforms have been recognized for imaging-guided diagnosis and 
      chemotherapy of cancer by integrating imaging function into the drug delivery 
      systems (DDSs). Here, a facile approach was developed for the fabrication of 
      polymeric prodrug microspheres by introducing pH sensitive "off-on" fluorochrome 
      Rhodamine 6G into bioreducible cleavable bisulfide crosslinked PEGylated 
      poly(glycidyl methacrylate) (PEG-PGMA) microspheres, followed with chemical 
      conjugation of doxorubicin (DOX) via an acid-labile hydrazone linkage. High drug 
      content of 25.4% was achieved for the final PEG-PGMA-Hy-DOX prodrug microspheres 
      with average hydrodynamic diameter of 332 nm. The in vitro controlled release 
      showed leakage-free in physiological medium but a sustained drug release up to 
      58% within 56 h in tumor intracellular microenvironment. The cellular experiments 
      showed that the PEG-PGMA-Hy-DOX prodrug microspheres could be effectively 
      internalized into HepG2 cells with enhanced anti-tumor efficacy than the free 
      DOX. Furthermore, they showed fluorescence only in tumor intracellular 
      microenvironment, indicating their promising potential for precise imaging-guided 
      diagnosis and chemotherapy.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Pei, Mingliang
AU  - Pei M
AD  - State Key Laboratory of Applied Organic Chemistry, College of Chemistry and 
      Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of 
      China.
FAU - Li, Guoping
AU  - Li G
AD  - State Key Laboratory of Applied Organic Chemistry, College of Chemistry and 
      Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of 
      China.
FAU - Ma, Kangwei
AU  - Ma K
AD  - State Key Laboratory of Applied Organic Chemistry, College of Chemistry and 
      Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of 
      China.
FAU - Li, Jianan
AU  - Li J
AD  - State Key Laboratory of Applied Organic Chemistry, College of Chemistry and 
      Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of 
      China.
FAU - Wang, Yuanfan
AU  - Wang Y
AD  - State Key Laboratory of Applied Organic Chemistry, College of Chemistry and 
      Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of 
      China.
FAU - Liu, Peng
AU  - Liu P
AD  - State Key Laboratory of Applied Organic Chemistry, College of Chemistry and 
      Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of 
      China. Electronic address: pliu@lzu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20190204
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Antibiotics, Antineoplastic)
RN  - 0 (Polymers)
RN  - 0 (Prodrugs)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Antibiotics, Antineoplastic/chemistry/*pharmacology
MH  - Apoptosis/drug effects
MH  - Cell Proliferation/drug effects
MH  - Cell Survival/drug effects
MH  - Doxorubicin/chemistry/*pharmacology
MH  - Drug Liberation
MH  - Drug Screening Assays, Antitumor
MH  - Fluorescence
MH  - Hep G2 Cells
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Microspheres
MH  - Molecular Structure
MH  - Particle Size
MH  - Polymers/*chemistry
MH  - Prodrugs/*chemistry
MH  - Surface Properties
MH  - Tumor Microenvironment/*drug effects
OTO - NOTNLM
OT  - Leakage-free
OT  - Polymeric prodrug microspheres
OT  - Precise imaging-guided diagnosis and chemotherapy
OT  - pH-triggered drug release
OT  - pH-triggered fluorescence
EDAT- 2019/02/17 06:00
MHDA- 2019/09/10 06:00
CRDT- 2019/02/17 06:00
PHST- 2018/10/11 00:00 [received]
PHST- 2019/01/29 00:00 [revised]
PHST- 2019/02/03 00:00 [accepted]
PHST- 2019/02/17 06:00 [pubmed]
PHST- 2019/09/10 06:00 [medline]
PHST- 2019/02/17 06:00 [entrez]
AID - S0927-7765(19)30076-1 [pii]
AID - 10.1016/j.colsurfb.2019.02.002 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2019 May 1;177:313-320. doi: 
      10.1016/j.colsurfb.2019.02.002. Epub 2019 Feb 4.