PMID- 30772095
OWN - NLM
STAT- MEDLINE
DCOM- 20200227
LR  - 20200227
IS  - 1878-3279 (Electronic)
IS  - 0171-2985 (Linking)
VI  - 224
IP  - 3
DP  - 2019 May
TI  - GRACE score of myocardial infarction patients correlates with oxidative stress 
      index, hsCRP and inflammation.
PG  - 433-439
LID - S0171-2985(18)30212-2 [pii]
LID - 10.1016/j.imbio.2019.02.001 [doi]
AB  - BACKGROUND: Etiopathogenesis of myocardial infarction (MI) is contributed by 
      oxidative injury and inflammatory response. The interplay of these processes 
      determines outcomes in MI patients. However, studies showing the relationship of 
      oxidative stress and inflammatory cytokines with prognosis and severity of MI are 
      lacking. OBJECTIVE: The present study was designed to assess the degree of 
      oxidative stress and inflammation in correlation with GRACE (Global Registry of 
      Acute Coronary Events) risk score in patients of MI. METHODS: MI patients were 
      segregated according to GRACE risk score and age. Blood samples of the patients 
      were used for determination of level of total peroxide, Total Antioxidant Status 
      (TAS), Oxidative Stress Index (OSI), pro-inflammatory molecules such as high 
      sensitive C-reactive protein (hsCRP), Tumor Necrosis Factor alpha (TNFalpha), interleukin 
      1 beta (IL 1beta), interleukin 6 (IL 6), anti-inflammatory cytokine interleukin 10 (IL 
      10), and TNFalpha/IL 10 cytokine ratio. RESULTS: We found significant elevation in 
      concentration of total peroxide, TAS and OSI in all MI patients than healthy 
      volunteers, this elevation showed pronouncement with higher GRACE score (GS) and 
      age. Alteration in pro-inflammatory and anti-inflammatory cytokines was seen in 
      MI patients than control group, and this alteration displayed polarization with 
      GS and age. CONCLUSION: MI patients with higher GS and age have greater degree of 
      OSI and inflammation, and these biochemical parameters were significantly 
      correlated with GS and thus disease severity.
CI  - Copyright (c) 2019 Elsevier GmbH. All rights reserved.
FAU - Shahzad, Sumayya
AU  - Shahzad S
AD  - Department of Biochemistry, Jawaharlal Nehru Medical College, Faculty of 
      Medicine, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India.
FAU - Mateen, Somaiya
AU  - Mateen S
AD  - Department of Biochemistry, Jawaharlal Nehru Medical College, Faculty of 
      Medicine, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India.
FAU - Hasan, Asif
AU  - Hasan A
AD  - Centre of Cardiology, Jawaharlal Nehru Medical College, Faculty of Medicine, 
      Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India.
FAU - Moin, Shagufta
AU  - Moin S
AD  - Department of Biochemistry, Jawaharlal Nehru Medical College, Faculty of 
      Medicine, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India. 
      Electronic address: moinshagufta2@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20190210
PL  - Netherlands
TA  - Immunobiology
JT  - Immunobiology
JID - 8002742
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - C-Reactive Protein/*metabolism
MH  - Cytokines/metabolism
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Inflammation/immunology/*metabolism
MH  - Inflammation Mediators/metabolism
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/immunology/*metabolism
MH  - *Oxidative Stress
MH  - Risk
MH  - Severity of Illness Index
MH  - Vascular Endothelial Growth Factor A/metabolism
OTO - NOTNLM
OT  - Pro inflammatory cytokines (TNFalpha, IL 1beta, IL 6) and anti-inflammatory cytokine (IL 
      10)
OT  - TNFalpha /IL 10 cytokine ratio
OT  - Total antioxidant status
OT  - Total peroxides
OT  - Vascular endothelial growth factor
EDAT- 2019/02/18 06:00
MHDA- 2020/02/28 06:00
CRDT- 2019/02/18 06:00
PHST- 2018/11/27 00:00 [received]
PHST- 2019/02/01 00:00 [revised]
PHST- 2019/02/01 00:00 [accepted]
PHST- 2019/02/18 06:00 [pubmed]
PHST- 2020/02/28 06:00 [medline]
PHST- 2019/02/18 06:00 [entrez]
AID - S0171-2985(18)30212-2 [pii]
AID - 10.1016/j.imbio.2019.02.001 [doi]
PST - ppublish
SO  - Immunobiology. 2019 May;224(3):433-439. doi: 10.1016/j.imbio.2019.02.001. Epub 
      2019 Feb 10.