PMID- 30772489
OWN - NLM
STAT- MEDLINE
DCOM- 20200715
LR  - 20200715
IS  - 1873-6815 (Electronic)
IS  - 0531-5565 (Linking)
VI  - 119
DP  - 2019 May
TI  - HSF1/HSP pathway in the hippocampus is involved in SIRT1-mediated caloric 
      restriction-induced neuroprotection after surgery in aged mice.
PG  - 184-192
LID - S0531-5565(18)30537-0 [pii]
LID - 10.1016/j.exger.2019.02.011 [doi]
AB  - Postoperative cognitive dysfunction is common in the elderly. Endoplasmic 
      reticulum stress (ER-stress) increases neuronal apoptosis after surgery, and 
      chaperone molecules, such as heat shock proteins (HSPs), help reduce unfolded 
      protein reactions, thereby promoting protein homeostasis. Mammal sirtuin1 
      (SIRT1)-mediated deacetylation of heat shock factor 1 (HSF1) upregulates HSF1 
      binding to the HSP70 promoter. Caloric restriction (CR) improves cognition in 
      many neurodegenerative models. In this study, we evaluated whether CR improves 
      impaired learning and memory after surgery by attenuating ER-stress in an 
      SIRT1-dependent manner. Male 18-month-old C57BL/6J mice receiving a 12-week CR or 
      an ad libitum (AL) diet pre-intervention were challenged with tibial open 
      fracture surgery and anesthesia or no treatment. We found a significant 
      protective effect of CR on memory in contextual fear conditioning test after 
      surgery compared with the AL group. CR alleviated ER-stress and neuronal 
      apoptosis in the hippocampus induced by surgery. CR increased HSP70 expression 
      through the HSF1/HSP pathway in a SIRT1-mediated manner, and inhibition of SIRT1 
      in the hippocampus by lentivirus injection partially reduced the benefits of CR 
      (increased HSP70, deacetylated HSF1, reduced ER-stress, and improved memory). 
      Taken together, our results showed that CR alleviates memory impairment 
      postoperatively via attenuation of ER-stress in the hippocampus in an 
      SIRT1-dependent manner, and the SIRT1/HSF1/HSP70 pathway is involved in this 
      process.
CI  - Copyright (c) 2019. Published by Elsevier Inc.
FAU - Yao, Minmin
AU  - Yao M
AD  - Department of Anesthesia, Zhongshan Hospital, Fudan University, Shanghai 200032, 
      China. Electronic address: yao.minmin@zs-hospital.sh.cn.
FAU - Zhao, Zhimeng
AU  - Zhao Z
AD  - Department of Anesthesia, Zhongshan Hospital, Fudan University, Shanghai 200032, 
      China.
FAU - Wei, Lan
AU  - Wei L
AD  - Department of Anesthesia, Zhongshan Hospital, Fudan University, Shanghai 200032, 
      China.
FAU - Zhou, Di
AU  - Zhou D
AD  - Department of Anesthesia, Zhongshan Hospital, Fudan University, Shanghai 200032, 
      China. Electronic address: zhou.di@zs-hospital.sh.cn.
FAU - Xue, Zhanggang
AU  - Xue Z
AD  - Department of Anesthesia, Zhongshan Hospital, Fudan University, Shanghai 200032, 
      China. Electronic address: xue.zhanggang@zs-hospital.sh.cn.
FAU - Ge, Shengjin
AU  - Ge S
AD  - Department of Anesthesia, Zhongshan Hospital, Fudan University, Shanghai 200032, 
      China. Electronic address: ge.shengjin@fudan.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190214
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
RN  - 0 (HSP70 Heat-Shock Proteins)
RN  - 0 (Heat Shock Transcription Factors)
RN  - 0 (Hsf1 protein, mouse)
RN  - EC 3.5.1.- (Sirt1 protein, mouse)
RN  - EC 3.5.1.- (Sirtuin 1)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - *Caloric Restriction
MH  - Cells, Cultured
MH  - Cognitive Dysfunction/*prevention & control
MH  - Endoplasmic Reticulum Stress
MH  - HSP70 Heat-Shock Proteins/*metabolism
MH  - Heat Shock Transcription Factors/deficiency/*physiology
MH  - Hippocampus/*metabolism
MH  - Lentivirus
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - *Neuroprotection
MH  - Sirtuin 1/deficiency/*physiology
MH  - Tibial Fractures/surgery
MH  - Up-Regulation
OTO - NOTNLM
OT  - Caloric restriction
OT  - HSF1
OT  - HSP70
OT  - Neuroprotection
OT  - SIRT1
EDAT- 2019/02/18 06:00
MHDA- 2020/07/16 06:00
CRDT- 2019/02/18 06:00
PHST- 2018/08/28 00:00 [received]
PHST- 2019/02/09 00:00 [revised]
PHST- 2019/02/12 00:00 [accepted]
PHST- 2019/02/18 06:00 [pubmed]
PHST- 2020/07/16 06:00 [medline]
PHST- 2019/02/18 06:00 [entrez]
AID - S0531-5565(18)30537-0 [pii]
AID - 10.1016/j.exger.2019.02.011 [doi]
PST - ppublish
SO  - Exp Gerontol. 2019 May;119:184-192. doi: 10.1016/j.exger.2019.02.011. Epub 2019 
      Feb 14.