PMID- 30774945
OWN - NLM
STAT- MEDLINE
DCOM- 20200302
LR  - 20200309
IS  - 2047-2994 (Electronic)
IS  - 2047-2994 (Linking)
VI  - 8
DP  - 2019
TI  - Neonatal sepsis due to glycopeptide resistant Enterococcus faecium from colonized 
      maternal gut- rare case evidence.
PG  - 29
LID - 10.1186/s13756-019-0490-x [doi]
LID - 29
AB  - BACKGROUND: Vancomycin-resistant enterococcal infections in the neonatal ICU are 
      growing global problems. We report a case of neonatal septicemia by 
      multidrug-resistant vancomycin-resistant Enterococcus faecium (VRE), the source 
      of infection being the mother's gut. CASE PRESENTATION: A newborn male child 
      admitted to the neonatal intensive care unit (NICU) was diagnosed to have mild 
      meconium aspiration syndrome, early onset neonatal septicemia, and bacteremia by 
      multidrug and vancomycin-resistant Enterococcus faecium. Screening of gut flora 
      of the baby and the mother were carried out to trace the source of infection. 
      Stool cultures of the mother and the baby yielded Vancomycin-Resistant 
      Enterococcus faecium. All three isolates of Enterococcus faecium had similar 
      antibiogram, harbored the vanA gene and similar pulsed-field gel electrophoresis 
      pattern. Baby responded to the 1 week therapy with oral linezolid suspension 
      20 mg/kg/day, 1 ml/t.d.s. No VRE was isolated from baby on a repeat stool culture 
      1 week after the linezolid therapy. He was discharged with the advice for the 
      continuance of linezolid for seven more days. CONCLUSION: Isolation of MDR-VRE 
      from the blood culture of the baby and stool specimens of the mother and the baby 
      with the same antibiogram profile and clonal similarities reveals that maternal 
      gut colonization was responsible for neonatal sepsis. Optimal infection control 
      measures and the development of guidelines for monitoring VRE colonization in 
      pregnant women might be useful in reducing the occurrence of neonatal sepsis.
FAU - Subramanya, Supram Hosuru
AU  - Subramanya SH
AUID- ORCID: 0000-0002-3488-4217
AD  - 1Department of Medical Microbiology, Manipal College of Medical Sciences, 
      Pokhara, Nepal.
FAU - Amberpet, Rajesh
AU  - Amberpet R
AD  - 2Melaka Manipal Medical College, Manipal, India.
AD  - 3Jawaharlal Institute of Postgraduate Medical Education & Research, Puducherry, 
      India.
FAU - Chaudhary, Dinesh
AU  - Chaudhary D
AD  - 1Department of Medical Microbiology, Manipal College of Medical Sciences, 
      Pokhara, Nepal.
FAU - Nayak, Niranjan
AU  - Nayak N
AD  - 1Department of Medical Microbiology, Manipal College of Medical Sciences, 
      Pokhara, Nepal.
FAU - Padukone, Shashiraja
AU  - Padukone S
AD  - 2Melaka Manipal Medical College, Manipal, India.
AD  - 3Jawaharlal Institute of Postgraduate Medical Education & Research, Puducherry, 
      India.
FAU - Bairy, Indira
AU  - Bairy I
AD  - 2Melaka Manipal Medical College, Manipal, India.
FAU - Gokhale, Shishir
AU  - Gokhale S
AD  - 1Department of Medical Microbiology, Manipal College of Medical Sciences, 
      Pokhara, Nepal.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20190208
PL  - England
TA  - Antimicrob Resist Infect Control
JT  - Antimicrobial resistance and infection control
JID - 101585411
RN  - 0 (Anti-Bacterial Agents)
RN  - 6Q205EH1VU (Vancomycin)
RN  - ISQ9I6J12J (Linezolid)
SB  - IM
MH  - Adult
MH  - Anti-Bacterial Agents/*pharmacology
MH  - Drug Resistance, Bacterial
MH  - Enterococcus faecium/classification/*drug effects/genetics/isolation & 
      purification
MH  - Feces/microbiology
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Intensive Care Units, Neonatal
MH  - Linezolid/administration & dosage
MH  - Male
MH  - Microbial Sensitivity Tests
MH  - Neonatal Sepsis/*microbiology
MH  - Vancomycin/administration & dosage
MH  - *Vancomycin Resistance
PMC - PMC6368750
OTO - NOTNLM
OT  - Gut colonization
OT  - Neonatal Sepsis
OT  - VRE
COIS- Written informed consent for this case report was obtained from the patient 
      mother in the study. Ethical approval was not required by our Institution, 
      necessary permission was taken for publication from Intuitional Scientific review 
      committee of Manipal College of Medical Sciences, Pokhara, Nepal.Written informed 
      consent for the publication of this case report was obtained from infant's 
      mother.The authors declare that they have no competing interests.Springer Nature 
      remains neutral with regard to jurisdictional claims in published maps and 
      institutional affiliations.
EDAT- 2019/02/19 06:00
MHDA- 2020/03/03 06:00
PMCR- 2019/02/08
CRDT- 2019/02/19 06:00
PHST- 2018/10/02 00:00 [received]
PHST- 2019/02/03 00:00 [accepted]
PHST- 2019/02/19 06:00 [entrez]
PHST- 2019/02/19 06:00 [pubmed]
PHST- 2020/03/03 06:00 [medline]
PHST- 2019/02/08 00:00 [pmc-release]
AID - 490 [pii]
AID - 10.1186/s13756-019-0490-x [doi]
PST - epublish
SO  - Antimicrob Resist Infect Control. 2019 Feb 8;8:29. doi: 
      10.1186/s13756-019-0490-x. eCollection 2019.