PMID- 30775464
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220331
IS  - 2405-5263 (Electronic)
IS  - 2405-5255 (Print)
IS  - 2405-5255 (Linking)
VI  - 2
IP  - 1
DP  - 2016 Mar
TI  - Femoral bone structure in Otsuka Long-Evans Tokushima Fatty rats.
PG  - 25-29
LID - 10.1016/j.afos.2015.12.001 [doi]
AB  - OBJECTIVES: Type 2 diabetes mellitus (T2DM) increases fracture risk despite 
      normal to high levels of bone mineral density. Bone quality is known to affect 
      bone fragility in T2DM. The aim of this study was to clarify the trabecular bone 
      microstructure and cortical bone geometry of the femur in T2DM model rats. 
      METHODS: Five-week-old Otsuka Long-Evans Tokushima Fatty (OLETF; n = 5) and 
      Long-Evans Tokushima Otsuka (LETO; n = 5) rats were used. At the age of 18 
      months, femurs were scanned with micro-computed tomography, and trabecular bone 
      microstructure and cortical bone geometry were analyzed. RESULTS: Trabecular bone 
      microstructure and cortical bone geometry deteriorated in the femur in OLETF 
      rats. Compared with in LETO rats, in OLETF rats, bone volume fraction, trabecular 
      number and connectivity density decreased, and trabecular space significantly 
      increased. Moreover, in OLETF rats, cortical bone volume and section area 
      decreased, and medullary volume significantly increased. CONCLUSIONS: Long-term 
      T2DM leaded to deterioration in trabecular and cortical bone structure. 
      Therefore, OLETF rats may serve as a useful animal model for investigating the 
      relationship between T2DM and bone quality.
FAU - Minematsu, Akira
AU  - Minematsu A
AD  - Department of Physical Therapy, Faculty of Health Science, Kio University, 4-2-2 
      Umaminaka, Koryo-cho, Kitakatsuragi-gun, Nara 635-0832, Japan.
FAU - Hanaoka, Tomoko
AU  - Hanaoka T
AD  - Division of Health Science, Graduate School of Health Science, Kio University, 
      4-2-2 Umaminaka, Koryo-cho, Kitakatsuragi-gun, Nara 635-0832, Japan.
FAU - Takada, Yoshihiro
AU  - Takada Y
AD  - Division of Health Science, Graduate School of Health Science, Kio University, 
      4-2-2 Umaminaka, Koryo-cho, Kitakatsuragi-gun, Nara 635-0832, Japan.
AD  - Department of Human Behavior, Faculty of Human Development, Kobe University, 3-11 
      Tsurukabuto, Nada-ku, Kobe, Hyogo 657-8501, Japan.
FAU - Okuda, Shunji
AU  - Okuda S
AD  - Department of Modern Education, Faculty of Education, Kio University, 4-2-2 
      Umaminaka, Koryo-cho, Kitakatsuragi-gun, Nara 635-0832, Japan.
FAU - Imagita, Hidetaka
AU  - Imagita H
AD  - Department of Physical Therapy, Faculty of Health Science, Kio University, 4-2-2 
      Umaminaka, Koryo-cho, Kitakatsuragi-gun, Nara 635-0832, Japan.
FAU - Sakata, Susumu
AU  - Sakata S
AD  - Department of Physiology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 
      634-8521, Japan.
LA  - eng
PT  - Journal Article
DEP - 20160314
PL  - Netherlands
TA  - Osteoporos Sarcopenia
JT  - Osteoporosis and sarcopenia
JID - 101666399
PMC - PMC6372729
OTO - NOTNLM
OT  - Cortical bone geometry
OT  - Micro-CT
OT  - Otsuka Long-Evans Tokushima Fatty (OLETF) rats
OT  - Trabecular bone microstructure
EDAT- 2016/03/01 00:00
MHDA- 2016/03/01 00:01
PMCR- 2016/03/14
CRDT- 2019/02/19 06:00
PHST- 2015/08/17 00:00 [received]
PHST- 2015/11/16 00:00 [revised]
PHST- 2015/12/31 00:00 [accepted]
PHST- 2019/02/19 06:00 [entrez]
PHST- 2016/03/01 00:00 [pubmed]
PHST- 2016/03/01 00:01 [medline]
PHST- 2016/03/14 00:00 [pmc-release]
AID - S2405-5255(15)30012-1 [pii]
AID - 10.1016/j.afos.2015.12.001 [doi]
PST - ppublish
SO  - Osteoporos Sarcopenia. 2016 Mar;2(1):25-29. doi: 10.1016/j.afos.2015.12.001. Epub 
      2016 Mar 14.