PMID- 30775877
OWN - NLM
STAT- MEDLINE
DCOM- 20191125
LR  - 20191125
IS  - 1433-6510 (Print)
IS  - 1433-6510 (Linking)
VI  - 65
IP  - 1
DP  - 2019 Jan 1
TI  - Anemia Combined Significantly Increased High-Sensitivity C Reactive Protein and 
      Lung Lesions Lead to the Diagnosis of Granulomatosis with Polyangiitis Proven by 
      Lung Biopsy and Anti-neutrophil Cytoplasmic Antibody Test.
LID - 10.7754/Clin.Lab.2018.180733 [doi]
AB  - <p><strong><em>Background</em></strong>: To report an atypical case misdiagnosed 
      as lung abscess over the past 2 months, but persistent anemia combined with 
      significantly increased hs-CRP and lung lesions indicated systemic lesion, which 
      led to the diagnosis of granulomatosis with polyangiitis proven by lung biopsy 
      and anti-neutrophil cytoplasmic antibody test (ANCA).</p> 
      <p><strong><em>Methods</em></strong>: The complete blood count, hs-CRP, and 
      anti-neutrophil cytoplasmic antibody (ANCA) test were performed. The pathology 
      consultation for the lung biopsy was arranged.</p> 
      <p><strong><em>Results</em></strong>: Hemoglobin was 8.5 g/L, hs-CRP was > 200 
      mg/L, c-ANCA directed against anti-proteinase 3 (PR3) was positive, pathology 
      consultation reported granulomatous inflammation.</p> <p> </p> <p> </p> <p> </p> 
      <p> </p> <p><strong><em>Conclusions</em></strong>: When patients have multiple 
      organ dysfunction combined with anemia and significantly increased hs-CRP, 
      physicians should pay attention to systemic vasculitis.</p>.
FAU - Ge, Yan L
AU  - Ge YL
FAU - Liu, Cong H
AU  - Liu CH
FAU - Wang, Meng H
AU  - Wang MH
FAU - Zhang, Jia B
AU  - Zhang JB
FAU - Chen, Hao
AU  - Chen H
FAU - Zhu, Xiao Y
AU  - Zhu XY
FAU - Li, Zhen Z
AU  - Li ZZ
FAU - Li, Hong L
AU  - Li HL
FAU - Cui, Zi Y
AU  - Cui ZY
FAU - Li, Li Q
AU  - Li LQ
FAU - Fu, Ai S
AU  - Fu AS
FAU - Wang, Hong Y
AU  - Wang HY
LA  - eng
PT  - Case Reports
PL  - Germany
TA  - Clin Lab
JT  - Clinical laboratory
JID - 9705611
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Anemia/*blood
MH  - Antibodies, Antineutrophil Cytoplasmic/*analysis/blood
MH  - Biopsy
MH  - C-Reactive Protein/*analysis
MH  - Diagnosis, Differential
MH  - Female
MH  - Granulomatosis with Polyangiitis/blood/*diagnosis
MH  - Humans
MH  - Lung/*pathology
MH  - Middle Aged
EDAT- 2019/02/19 06:00
MHDA- 2019/11/26 06:00
CRDT- 2019/02/19 06:00
PHST- 2019/02/19 06:00 [entrez]
PHST- 2019/02/19 06:00 [pubmed]
PHST- 2019/11/26 06:00 [medline]
AID - 10.7754/Clin.Lab.2018.180733 [doi]
PST - ppublish
SO  - Clin Lab. 2019 Jan 1;65(1). doi: 10.7754/Clin.Lab.2018.180733.