PMID- 30776268
OWN - NLM
STAT- MEDLINE
DCOM- 20190611
LR  - 20190613
IS  - 1651-2251 (Electronic)
IS  - 0001-6489 (Linking)
VI  - 138
IP  - 11
DP  - 2018 Nov
TI  - Retrospective analysis of 659 laryngeal squamous cell carcinoma patients treated 
      with open laryngeal function-preserving operations.
PG  - 1043-1050
LID - 10.1080/00016489.2018.1500711 [doi]
AB  - BACKGROUND: Open laryngeal function-preserving surgery is a common therapeutic 
      strategy for Chinese laryngeal squamous cell carcinoma (LSCC) patients. 
      OBJECTIVES: To explore the fundamental clinical characteristics and survival 
      prognostic factors of LSCC patients treated with open laryngeal 
      function-preserving operations. MATERIAL AND METHODS: about a total of 659 LSCC 
      patients undergoing open laryngeal function-preserving operations were 
      retrospectively reviewed. Kaplan-Meier method, Log-rank test and Cox regression 
      model were performed in survival analyses. RESULTS: About 612 patients were 
      glottic cancer, followed by 44 cases in supraglottis and 3 cases in subglottis. 
      The number of patients in stage T1, T2, T3 and T4 was 190, 365, 100 and 4, 
      respectively. Nineteen patients had positive cervical lymph nodes. The 5-year 
      overall survival, disease-free survival and disease-specific survival rates were 
      90.1, 84.9 and 90.7%, respectively. T stage and second primary tumour were 
      independent factors predicting overall survival, while T stage and pathological 
      differentiation were independent risk factors for tumour recurrence and 
      progression. CONCLUSIONS AND SIGNIFICANCE: Open laryngeal function-preserving 
      surgery is a crucial therapeutic strategy for Chinese patients with early and, in 
      some cases, advanced-stage LSCC. Early diagnosis and therapy and sufficient and 
      safe surgical margins are key to improving the survival rate and reducing the 
      risk of relapse in LSCC patients.
FAU - Tang, Di
AU  - Tang D
FAU - Tao, Lei
AU  - Tao L
AD  - a Department of Otolaryngology , Eye Ear Nose and Throat Hospital, Fudan 
      University , Shanghai , China.
FAU - Zhou, Liang
AU  - Zhou L
AD  - a Department of Otolaryngology , Eye Ear Nose and Throat Hospital, Fudan 
      University , Shanghai , China.
FAU - Zhang, Ming
AU  - Zhang M
AD  - a Department of Otolaryngology , Eye Ear Nose and Throat Hospital, Fudan 
      University , Shanghai , China.
FAU - Wu, Haitao
AU  - Wu H
AD  - a Department of Otolaryngology , Eye Ear Nose and Throat Hospital, Fudan 
      University , Shanghai , China.
FAU - Li, Xiaoming
AU  - Li X
AD  - a Department of Otolaryngology , Eye Ear Nose and Throat Hospital, Fudan 
      University , Shanghai , China.
FAU - Chen, Xiaoling
AU  - Chen X
AD  - a Department of Otolaryngology , Eye Ear Nose and Throat Hospital, Fudan 
      University , Shanghai , China.
FAU - Li, Cai
AU  - Li C
AD  - a Department of Otolaryngology , Eye Ear Nose and Throat Hospital, Fudan 
      University , Shanghai , China.
FAU - Xie, Ming
AU  - Xie M
AD  - a Department of Otolaryngology , Eye Ear Nose and Throat Hospital, Fudan 
      University , Shanghai , China.
FAU - Cheng, Lei
AU  - Cheng L
AD  - a Department of Otolaryngology , Eye Ear Nose and Throat Hospital, Fudan 
      University , Shanghai , China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Acta Otolaryngol
JT  - Acta oto-laryngologica
JID - 0370354
SB  - IM
MH  - Aged
MH  - Carcinoma, Squamous Cell/mortality/pathology/*surgery
MH  - China
MH  - Cohort Studies
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Laryngeal Neoplasms/mortality/pathology/*surgery
MH  - Larynx/*physiology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Neoplasm Invasiveness/pathology
MH  - Neoplasm Recurrence, Local/mortality/pathology/surgery
MH  - Neoplasm Staging
MH  - Organ Sparing Treatments/*methods
MH  - Otorhinolaryngologic Surgical Procedures/methods
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Survival Analysis
OTO - NOTNLM
OT  - Laryngeal squamous cell carcinoma
OT  - open laryngeal function-preserving operation
OT  - risk factors
OT  - survival prognosis
EDAT- 2019/02/19 06:00
MHDA- 2019/06/14 06:00
CRDT- 2019/02/19 06:00
PHST- 2019/02/19 06:00 [entrez]
PHST- 2019/02/19 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
AID - 10.1080/00016489.2018.1500711 [doi]
PST - ppublish
SO  - Acta Otolaryngol. 2018 Nov;138(11):1043-1050. doi: 10.1080/00016489.2018.1500711.