PMID- 30776616 OWN - NLM STAT- MEDLINE DCOM- 20190606 LR - 20190606 IS - 1873-4235 (Electronic) IS - 0956-5663 (Linking) VI - 130 DP - 2019 Apr 1 TI - Enhanced surface plasmon resonance (SPR) signals based on immobilization of core-shell nanoparticles incorporated boron nitride nanosheets: Development of molecularly imprinted SPR nanosensor for anticancer drug, etoposide. PG - 293-298 LID - S0956-5663(19)30082-X [pii] LID - 10.1016/j.bios.2019.01.053 [doi] AB - An effective SPR nanosensor based on core-shell nanoparticles (Ag@AuNPs) incorporated hexagonal boron nitride (HBN) nanosheets and molecularly imprinted polymer (MIP) was presented for etoposide (ETO) detection. Scanning electron microscope (SEM), transmission electron microscope (TEM), x-ray diffraction (XRD) method, cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), fourier transform infrared (FTIR) spectroscopy and atomic force microscopy (AFM) methods were utilized for all characterizations of nanomaterials and polymer surfaces. ETO imprinted SPR nanosensor based on Ag@AuNPs-HBN nanocomposite was developed in the presence of poly(2-hydroxyethyl methacrylate-methacryloylamidoglutamic acid) [p(HEMA-MAGA)]. The results of the study have revealed that 0.001-1.00 ng mL(-1) (1.70 x 10(-12)-1.70 x 10(-9) M) and 0.00025 ng mL(-1) (4.25 x 10(-13) M) were found as the linearity range and the detection limit (LOD). Furthermore, the prepared SPR nanosensor was examined in terms of stability, repeatability and selectivity. Finally, the imprinted SPR nanosensor was applied to the urine samples having high recovery. CI - Copyright (c) 2019 Elsevier B.V. All rights reserved. FAU - Ozkan, Abdullah AU - Ozkan A AD - Iskenderun Technical University, Faculty of Engineering and Natural Sciences, Department of Petroleum and Natural Gas, Hatay, Turkey. FAU - Atar, Necip AU - Atar N AD - Pamukkale University, Faculty of Engineering, Department of Chemical Engineering, Denizli, Turkey. FAU - Yola, Mehmet Lutfi AU - Yola ML AD - Iskenderun Technical University, Faculty of Engineering and Natural Sciences, Department of Biomedical Engineering, Hatay, Turkey. Electronic address: mlutfi.yola@iste.edu.tr. LA - eng PT - Journal Article DEP - 20190131 PL - England TA - Biosens Bioelectron JT - Biosensors & bioelectronics JID - 9001289 RN - 0 (Antineoplastic Agents) RN - 0 (Boron Compounds) RN - 0 (Polymers) RN - 2U4T60A6YD (boron nitride) RN - 6PLQ3CP4P3 (Etoposide) RN - 7440-57-5 (Gold) SB - IM MH - Antineoplastic Agents/chemistry/*isolation & purification MH - *Biosensing Techniques MH - Boron Compounds/chemistry MH - Dielectric Spectroscopy MH - Etoposide/chemistry/*isolation & purification/therapeutic use MH - Gold/chemistry MH - Humans MH - Metal Nanoparticles/*chemistry MH - Molecular Imprinting MH - Neoplasms/drug therapy MH - Polymers/chemistry MH - Spectroscopy, Fourier Transform Infrared MH - Surface Plasmon Resonance OTO - NOTNLM OT - Core-shell nanoparticles OT - Etoposide OT - Hexagonal boron nitride OT - Molecular imprinted nanosensor OT - Urine sample EDAT- 2019/02/19 06:00 MHDA- 2019/06/07 06:00 CRDT- 2019/02/19 06:00 PHST- 2018/11/12 00:00 [received] PHST- 2019/01/20 00:00 [revised] PHST- 2019/01/22 00:00 [accepted] PHST- 2019/02/19 06:00 [pubmed] PHST- 2019/06/07 06:00 [medline] PHST- 2019/02/19 06:00 [entrez] AID - S0956-5663(19)30082-X [pii] AID - 10.1016/j.bios.2019.01.053 [doi] PST - ppublish SO - Biosens Bioelectron. 2019 Apr 1;130:293-298. doi: 10.1016/j.bios.2019.01.053. Epub 2019 Jan 31.