PMID- 30776705 OWN - NLM STAT- MEDLINE DCOM- 20200617 LR - 20200617 IS - 1879-1379 (Electronic) IS - 0022-3956 (Linking) VI - 111 DP - 2019 Apr TI - Psychometric liability to psychosis and childhood adversities are associated with shorter telomere length: A study on schizophrenia patients, unaffected siblings, and non-clinical controls. PG - 169-185 LID - S0022-3956(18)31062-8 [pii] LID - 10.1016/j.jpsychires.2019.01.022 [doi] AB - Compared to the general population, individuals diagnosed with Schizophrenia (SCZ) experience a higher frequency and an earlier onset of chronic medical disorders, resulting in a reduction in life expectancy by an average of 15-25 years. Recently, it has been hypothesized that SCZ is a syndrome of accelerated aging. Childhood adversity was also associated with the pathogenesis and course of SCZ. Our hypothesis was that both SCZ patients and their unaffected siblings would have shorter telomere length (TL) compared to of non-clinical controls. Our additional goals were to determine (1) whether shorter TL correlates with intermediate phenotypes of SCZ (i.e. Psychosis-like symptoms and schizotypal traits); and (2) whether childhood adversities have a moderating role in TL shortening among SCZ and their unaffected siblings. To this end, SCZ patients (n = 100), their unaffected siblings (n = 100) and non-clinical controls (n = 100) were enrolled. The main variables were TL, measured by aTL-qPCR; psychotic-like and schizotypal symptoms, assessed by The Community Assessment of Psychic Experience (CAPE) and the Structured Interview for Schizotypy-Revised (SIS-R), respectively; and childhood adversities evaluated by the Childhood Experience of Care and Abuse (CECA)-Interview. Potentially relevant variables also included in the analyses were: Global Assessment of Functioning (GAF) scores, cognitive performance, and socio-demographic features. In contrast to our hypothesis patients had similar TL when compared to the non-clinical controls. Interestingly, unaffected siblings had longer TL compared to both patients and controls (p < 0.001). Independent from group status a negative correlation was observed between TL and psychotic-like symptoms as rated by the CAPE (p < 0.01). Childhood adversities, especially loneliness between ages 0 and 11 were also negatively associated with TL (p < 0.05). Our findings suggest that psychometric liability to psychosis and childhood adversities may be associated with shorter TL. Unaffected siblings had longer TL, suggesting the potential role of resilience on both the TL and the clinical presentation. These findings must be considered preliminary, calling for larger-scale replication efforts. CI - Copyright (c) 2019 Elsevier Ltd. All rights reserved. FAU - Cevik, Burcu AU - Cevik B AD - Brain Research Center, Ankara University, Ankara, Turkey; Biotechnology Institute, Ankara University, Ankara, Turkey. FAU - Mance-Calisir, Oyku AU - Mance-Calisir O AD - Brain Research Center, Ankara University, Ankara, Turkey. FAU - Atbasoglu, Esref Cem AU - Atbasoglu EC AD - Department of Psychiatry, Ankara University Faculty of Medicine, Ankara, Turkey. FAU - Saka, Meram Can AU - Saka MC AD - Department of Psychiatry, Ankara University Faculty of Medicine, Ankara, Turkey. FAU - Alptekin, Koksal AU - Alptekin K AD - Department of Psychiatry, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey. FAU - Ucok, Alp AU - Ucok A AD - Department of Psychiatry, Istanbul University Faculty of Medicine, Istanbul, Turkey. FAU - Sirmatel, Burcu AU - Sirmatel B AD - Department of Physiology, Gazi University Faculty of Medicine, Ankara, Turkey. FAU - Guloksuz, Sinan AU - Guloksuz S AD - Department of Psychiatry and Neuropsychology Maastricht University Medical Center, Maastricht, the Netherlands; Department of Psychiatry, Yale School of Medicine, New Haven, USA. FAU - Tukun, Ajlan AU - Tukun A AD - Center of Genetic Diagnosis, Duzen Laboratories Group, Ankara, Turkey. FAU - van Os, Jim AU - van Os J AD - Maastricht University Medical Centre, Maastricht, the Netherlands; Brain Centre Rudolf Magnus, Utrecht University Medical Centre, Utrecht, the Netherlands; King's College London, Department of Psychosis Studies, Institute of Psychiatry, London, UK. FAU - Gumus-Akay, Guvem AU - Gumus-Akay G AD - Brain Research Center, Ankara University, Ankara, Turkey. Electronic address: ggumusakay@ankara.edu.tr. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20190208 PL - England TA - J Psychiatr Res JT - Journal of psychiatric research JID - 0376331 SB - IM MH - Adolescent MH - Adult MH - *Adverse Childhood Experiences MH - *Disease Susceptibility MH - Female MH - Gene-Environment Interaction MH - Humans MH - Loneliness/*psychology MH - Male MH - Middle Aged MH - Psychological Trauma/*psychology MH - Psychometrics MH - Psychotic Disorders/*genetics/*psychology MH - Resilience, Psychological MH - Schizophrenia/*genetics MH - Siblings MH - Telomere Shortening/*genetics MH - Young Adult OTO - NOTNLM OT - Childhood trauma OT - Healthy siblings OT - Psychometric liability to psychosis OT - Resilience OT - Schizophrenia OT - Telomere length EDAT- 2019/02/19 06:00 MHDA- 2020/06/18 06:00 CRDT- 2019/02/19 06:00 PHST- 2018/09/04 00:00 [received] PHST- 2018/12/20 00:00 [revised] PHST- 2019/01/27 00:00 [accepted] PHST- 2019/02/19 06:00 [pubmed] PHST- 2020/06/18 06:00 [medline] PHST- 2019/02/19 06:00 [entrez] AID - S0022-3956(18)31062-8 [pii] AID - 10.1016/j.jpsychires.2019.01.022 [doi] PST - ppublish SO - J Psychiatr Res. 2019 Apr;111:169-185. doi: 10.1016/j.jpsychires.2019.01.022. Epub 2019 Feb 8.