PMID- 30776982
OWN - NLM
STAT- MEDLINE
DCOM- 20200424
LR  - 20200424
IS  - 1568-5624 (Electronic)
IS  - 0920-5063 (Linking)
VI  - 30
IP  - 6
DP  - 2019 Apr
TI  - Tissue response to porous high density polyethylene as a three-dimensional 
      scaffold for bone tissue engineering: An experimental study.
PG  - 486-499
LID - 10.1080/09205063.2019.1582278 [doi]
AB  - High density polyethylene (HDPE) is a synthetic biomaterial used as a 
      three-dimensional scaffold for bone defect reconstruction. Reports differ with 
      regard to its biological response, particularly its osteoconductive capacity. The 
      aim of the present work was to histologically and histomorphometrically evaluate 
      tissue response to porous HDPE. An in vivo study was conducted in rat tibia to 
      evaluate osteogenic capacity, angiogenesis, inflammatory response, and the 
      presence of multinucleated giant cells 14 and 60 days post-biomaterial 
      implantation. Histological examination 14 days post-implantation showed 
      fibrovascular tissue inside pores and on the surface of porous HDPE, acute 
      inflammatory response, scant multinucleated giant cells (MNGCs), and lamellar 
      bone in contact with the biomaterial. An increase in the proportion of lamellar 
      bone tissue, no inflammatory response, and a decrease in the number of MNGCs were 
      observed at 60 days. The histomorphometric study showed a significant 
      time-dependent increase both in the area of bone tissue formed in contact with 
      the porous HDPE (14d: 24.450 +/- 11.623 microm(2) vs. 60d: 77.104 +/- 26.217 microm(2), 
      p < 0.05) and in the percentage of bone tissue in contact with the porous HDPE 
      (osseointegration). A significant decrease in the number of MNGCs was also 
      observed at 60 days post-implantation. Porous HDPE showed adequate 
      osteoconductive properties, and only caused an initial inflammatory response. 
      Although this biomaterial has traditionally been used juxtaosseoulsy, its 
      adequate osteoconductive properties broaden the scope of its application to 
      include intraosseous placement.
FAU - Martinez Rodriguez, Juliana
AU  - Martinez Rodriguez J
AD  - a Universidad de Buenos Aires, Catedra de Anatomia Patologica, Facultad de 
      Odontologia , Buenos Aires , Argentina.
FAU - Renou, Sandra J
AU  - Renou SJ
AD  - a Universidad de Buenos Aires, Catedra de Anatomia Patologica, Facultad de 
      Odontologia , Buenos Aires , Argentina.
FAU - Guglielmotti, Maria B
AU  - Guglielmotti MB
AD  - a Universidad de Buenos Aires, Catedra de Anatomia Patologica, Facultad de 
      Odontologia , Buenos Aires , Argentina.
AD  - b National Research Council (CONICET) , Buenos Aires , Argentina.
FAU - Olmedo, Daniel G
AU  - Olmedo DG
AD  - a Universidad de Buenos Aires, Catedra de Anatomia Patologica, Facultad de 
      Odontologia , Buenos Aires , Argentina.
AD  - b National Research Council (CONICET) , Buenos Aires , Argentina.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190308
PL  - England
TA  - J Biomater Sci Polym Ed
JT  - Journal of biomaterials science. Polymer edition
JID - 9007393
RN  - 0 (Biocompatible Materials)
RN  - 9002-88-4 (Polyethylene)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/*chemistry/*pharmacology
MH  - Male
MH  - Polyethylene/*chemistry/*pharmacology
MH  - Porosity
MH  - Rats
MH  - Tibia/cytology/*drug effects
MH  - *Tissue Engineering
MH  - Tissue Scaffolds/*chemistry
OTO - NOTNLM
OT  - Porous high density polyethylene
OT  - biomaterials
OT  - bone regeneration
OT  - osteogenesis
OT  - three-dimensional scaffolds
EDAT- 2019/02/20 06:00
MHDA- 2020/04/25 06:00
CRDT- 2019/02/20 06:00
PHST- 2019/02/20 06:00 [pubmed]
PHST- 2020/04/25 06:00 [medline]
PHST- 2019/02/20 06:00 [entrez]
AID - 10.1080/09205063.2019.1582278 [doi]
PST - ppublish
SO  - J Biomater Sci Polym Ed. 2019 Apr;30(6):486-499. doi: 
      10.1080/09205063.2019.1582278. Epub 2019 Mar 8.