PMID- 30778713
OWN - NLM
STAT- MEDLINE
DCOM- 20190722
LR  - 20220129
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Print)
IS  - 1569-5794 (Linking)
VI  - 35
IP  - 7
DP  - 2019 Jul
TI  - Combined T1-mapping and tissue tracking analysis predicts severity of ischemic 
      injury following acute STEMI-an Oxford Acute Myocardial Infarction (OxAMI) study.
PG  - 1297-1308
LID - 10.1007/s10554-019-01542-8 [doi]
AB  - Early risk stratification after ST-segment-elevation myocardial infarction 
      (STEMI) is of major clinical importance. Strain quantifies myocardial deformation 
      and can demonstrate abnormal global and segmental myocardial function in acute 
      ischaemia. Native T1-mapping allows assessment of the severity of acute ischemic 
      injury, however its clinical applicability early post MI is limited by the 
      complex dynamic changes happening in the myocardium post MI. We aimed to explore 
      relationship between T1-mapping and feature tracking imaging, to establish 
      whether combined analysis of these parameters could predict recovery after STEMI. 
      96 STEMI patients (aged 60 +/- 11) prospectively recruited in the Oxford Acute 
      Myocardial Infarction (OxAMI) study underwent 3T-CMR scans acutely (within 
      53 +/- 32 h from primary percutaneous coronary intervention) and at 6 months (6M). 
      The imaging protocol included: cine, ShMOLLI T1-mapping and late gadolinium 
      enhancement (LGE). Segments were divided in the infarct, adjacent and remote 
      zones based on the presence of LGE. Peak circumferential (Ecc) and radial (Err) 
      strain was assessed using cvi42 software. Acute segmental strain correlated with 
      segmental T1-mapping values (T1 vs. Err - 0.75 +/- 0.25, p < 0.01; T1 vs. Ecc 
      0.72 +/- 0.32, p < 0.01) and with LGE segmental injury (LGE vs. Err - 0.56 +/- 0.29, 
      p < 0.01; LGE vs. Ecc 0.54 +/- 0.35, p < 0.01). Moreover, acute segmental T1 and 
      strain predicted segmental LGE transmurality on 6M scans (p < 0.001, r = 0.5). 
      Multiple regression analysis confirmed combined analysis of global Ecc and 
      T1-mapping was significantly better than either method alone in predicting final 
      infarct size at 6M (r = 0.556 vs r = 0.473 for global T1 only and r = 0.476 for 
      global Ecc only, p < 0.001). This novel CMR method combining T1-mapping and 
      feature tracking analysis of acute CMR scans predicts LGE transmurality and 
      infarct size at 6M following STEMI.
FAU - Wamil, Malgorzata
AU  - Wamil M
AD  - Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John 
      Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK.
AD  - NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, OX3 9DU, 
      UK.
FAU - Borlotti, Alessandra
AU  - Borlotti A
AD  - Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John 
      Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK.
AD  - NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, OX3 9DU, 
      UK.
FAU - Liu, Dan
AU  - Liu D
AD  - Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John 
      Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK.
AD  - NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, OX3 9DU, 
      UK.
FAU - Briosa E Gala, Andre
AU  - Briosa E Gala A
AD  - Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John 
      Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK.
AD  - NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, OX3 9DU, 
      UK.
FAU - Bracco, Alessia
AU  - Bracco A
AD  - Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John 
      Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK.
AD  - NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, OX3 9DU, 
      UK.
FAU - Alkhalil, Mohammad
AU  - Alkhalil M
AD  - Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John 
      Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK.
AD  - NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, OX3 9DU, 
      UK.
FAU - De Maria, Giovanni Luigi
AU  - De Maria GL
AD  - Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John 
      Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK.
AD  - NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, OX3 9DU, 
      UK.
FAU - Piechnik, Stefan K
AU  - Piechnik SK
AD  - Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John 
      Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK.
AD  - NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, OX3 9DU, 
      UK.
FAU - Ferreira, Vanessa M
AU  - Ferreira VM
AD  - Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John 
      Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK.
AD  - NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, OX3 9DU, 
      UK.
FAU - Banning, Adrian P
AU  - Banning AP
AD  - Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John 
      Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK.
AD  - NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, OX3 9DU, 
      UK.
FAU - Kharbanda, Rajesh K
AU  - Kharbanda RK
AD  - Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John 
      Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK.
AD  - NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, OX3 9DU, 
      UK.
FAU - Neubauer, Stefan
AU  - Neubauer S
AD  - Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John 
      Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK.
AD  - NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, OX3 9DU, 
      UK.
FAU - Choudhury, Robin P
AU  - Choudhury RP
AD  - Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John 
      Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK.
AD  - NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, OX3 9DU, 
      UK.
FAU - Channon, Keith M
AU  - Channon KM
AD  - Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John 
      Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK.
AD  - NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, OX3 9DU, 
      UK.
FAU - Dall'Armellina, Erica
AU  - Dall'Armellina E
AD  - Acute Vascular Imaging Centre, Radcliffe Department of Medicine, John Radcliffe 
      Hospital, Oxford, OX3 9DU, UK. E.DallArmellina@leeds.ac.uk.
AD  - The Leeds Institute of Cardiovascular and Metabolic Medicine, Division of 
      Biomedical Imaging, University of Leeds, Leeds, UK. E.DallArmellina@leeds.ac.uk.
LA  - eng
GR  - FS/13/71/30378/BHF_/British Heart Foundation/United Kingdom
GR  - intermediate fellowship/BHF_/British Heart Foundation/United Kingdom
GR  - ch/16/1/32013/BHF_/British Heart Foundation/United Kingdom
GR  - fellowship/BHF Centre of Research Excellence, Oxford/
PT  - Journal Article
DEP - 20190216
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
RN  - 0 (Contrast Media)
SB  - IM
MH  - Aged
MH  - Contrast Media/administration & dosage
MH  - Female
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Percutaneous Coronary Intervention
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - ST Elevation Myocardial Infarction/*diagnostic 
      imaging/pathology/physiopathology/surgery
MH  - Severity of Illness Index
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC6598944
OTO - NOTNLM
OT  - Cardiac magnetic resonance
OT  - Myocardial infarction
OT  - Strain
COIS- The authors of this manuscript declare no relationships with any companies, whose 
      products or services may be related to the subject matter of the article.
EDAT- 2019/02/20 06:00
MHDA- 2019/07/23 06:00
PMCR- 2019/02/16
CRDT- 2019/02/20 06:00
PHST- 2018/11/09 00:00 [received]
PHST- 2019/01/18 00:00 [accepted]
PHST- 2019/02/20 06:00 [pubmed]
PHST- 2019/07/23 06:00 [medline]
PHST- 2019/02/20 06:00 [entrez]
PHST- 2019/02/16 00:00 [pmc-release]
AID - 10.1007/s10554-019-01542-8 [pii]
AID - 1542 [pii]
AID - 10.1007/s10554-019-01542-8 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2019 Jul;35(7):1297-1308. doi: 
      10.1007/s10554-019-01542-8. Epub 2019 Feb 16.