PMID- 30778846
OWN - NLM
STAT- MEDLINE
DCOM- 20200413
LR  - 20200413
IS  - 1708-0428 (Electronic)
IS  - 0960-8923 (Linking)
VI  - 29
IP  - 6
DP  - 2019 Jun
TI  - The Effect of Gastric Bypass with a Distal Gastric Pouch on Glucose Tolerance and 
      Diabetes Remission in Type 2 Diabetes Sprague-Dawley Rat Model.
PG  - 1889-1900
LID - 10.1007/s11695-019-03776-w [doi]
AB  - BACKGROUND: Gastric bypass with a proximal gastric pouch (Roux-en-Y gastric 
      bypass) induces early diabetes remission. The effect of gastric bypass with a 
      distal gastric pouch remains unknown. OBJECTIVE: To observe the effect on glucose 
      tolerance and diabetes remission of gastric bypass with a distal gastric pouch. 
      METHOD: A type 2 diabetes (T2D) model was created in 44 Sprague-Dawley (SD) rats 
      that randomly underwent Roux-en-Y gastric bypass (RYGB, n = 8); gastric bypass 
      with duodenal-jejunal transit (GB-DJT, n = 8); distal-pouch gastric bypass with 
      duodenal-jejunal transit (DPGB-DJT, n = 8); distal-pouch gastric bypass with 
      duodenal-jejunal bypass (DPGB-DJB, n = 8); sham (n = 6); and Roux-en-Y gastric 
      bypass with esophageal re-anastomosis (RYGB-Er, n = 6) surgery. In the DPGB-DJT 
      and the DPGB-DJB groups, the gastric pouch was created in the distal stomach. In 
      the RYGB and the GB-DJT groups, the gastric pouch was created in the proximal 
      stomach. An oral glucose tolerance test (OGTT), insulin tolerance test (ITT) and 
      mixed-meal tolerance test (MMTT) conducted preoperatively were repeated 
      postoperatively. RESULTS: GLP-1 AUC recorded preoperatively was significantly 
      increased 8 weeks postoperatively in the RYGB, GB-DJT, and DPGB-DJB groups. 
      Increased GLP-1 AUC in the DPGB-DJT did not reach statistical significance. 
      Improved glucose tolerance in the RYGB and GB-DJT groups was significantly higher 
      than DPGB-DJT group. DPGB-DJB did not improve glucose tolerance significantly. 
      Gastrin level was increased significantly in the DPGB-DJT and DPGB-DJB groups. 
      CONCLUSION: In gastric bypass, creating the gastric pouch in the distal region of 
      the stomach significantly impairs the glucose tolerance and diabetes remission in 
      spite of the increased GLP-1 and insulin responses in T2D SD rat model, 
      suggesting that bypassing the distal stomach may be the key mediator of early 
      diabetes remission after RYGB.
FAU - Dolo, Ponnie Robertlee
AU  - Dolo PR
AUID- ORCID: 0000-0002-6535-3574
AD  - Department of General Surgery, The Affiliated Hospital of Xuzhou Medical 
      University, Xuzhou, 221006, Jiangsu, People's Republic of China.
AD  - Institute of Digestive Diseases, Xuzhou Medical University, Xuzhou, 221006, 
      Jiangsu, People's Republic of China.
FAU - Shao, Yong
AU  - Shao Y
AD  - Department of General Surgery, The Affiliated Hospital of Xuzhou Medical 
      University, Xuzhou, 221006, Jiangsu, People's Republic of China.
AD  - Institute of Digestive Diseases, Xuzhou Medical University, Xuzhou, 221006, 
      Jiangsu, People's Republic of China.
FAU - Li, Chao
AU  - Li C
AD  - Department of General Surgery, The Affiliated Hospital of Xuzhou Medical 
      University, Xuzhou, 221006, Jiangsu, People's Republic of China.
AD  - Institute of Digestive Diseases, Xuzhou Medical University, Xuzhou, 221006, 
      Jiangsu, People's Republic of China.
FAU - Zhu, Xiaocheng
AU  - Zhu X
AD  - Department of General Surgery, The Affiliated Hospital of Xuzhou Medical 
      University, Xuzhou, 221006, Jiangsu, People's Republic of China. zhuxccf@163.com.
AD  - Institute of Digestive Diseases, Xuzhou Medical University, Xuzhou, 221006, 
      Jiangsu, People's Republic of China. zhuxccf@163.com.
FAU - Yao, Libin
AU  - Yao L
AD  - Department of General Surgery, The Affiliated Hospital of Xuzhou Medical 
      University, Xuzhou, 221006, Jiangsu, People's Republic of China.
AD  - Institute of Digestive Diseases, Xuzhou Medical University, Xuzhou, 221006, 
      Jiangsu, People's Republic of China.
FAU - Wang, Hui
AU  - Wang H
AD  - Department of General Surgery, The Affiliated Hospital of Xuzhou Medical 
      University, Xuzhou, 221006, Jiangsu, People's Republic of China.
AD  - Institute of Digestive Diseases, Xuzhou Medical University, Xuzhou, 221006, 
      Jiangsu, People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Obes Surg
JT  - Obesity surgery
JID - 9106714
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Blood Glucose/*metabolism
MH  - Diabetes Mellitus, Experimental/*metabolism
MH  - Diabetes Mellitus, Type 2/*metabolism/surgery
MH  - *Gastric Bypass/methods
MH  - Glucagon-Like Peptide 1/metabolism
MH  - Glucose Tolerance Test
MH  - Insulin/metabolism
MH  - Insulin Resistance/physiology
MH  - Male
MH  - Obesity, Morbid/metabolism/*surgery
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Remission Induction
OTO - NOTNLM
OT  - Distal stomach, antrum
OT  - Duodenal-jejunal bypass
OT  - Foregut
OT  - GLP-1
OT  - Gastric bypass
OT  - Gastrin
OT  - Type 2 diabetes
EDAT- 2019/02/20 06:00
MHDA- 2020/04/14 06:00
CRDT- 2019/02/20 06:00
PHST- 2019/02/20 06:00 [pubmed]
PHST- 2020/04/14 06:00 [medline]
PHST- 2019/02/20 06:00 [entrez]
AID - 10.1007/s11695-019-03776-w [pii]
AID - 10.1007/s11695-019-03776-w [doi]
PST - ppublish
SO  - Obes Surg. 2019 Jun;29(6):1889-1900. doi: 10.1007/s11695-019-03776-w.