PMID- 30780103
OWN - NLM
STAT- MEDLINE
DCOM- 20190722
LR  - 20190722
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 112
DP  - 2019 Apr
TI  - The role of microRNA-16 in the pathogenesis of autoimmune diseases: A 
      comprehensive review.
PG  - 108583
LID - S0753-3322(18)38020-X [pii]
LID - 10.1016/j.biopha.2019.01.044 [doi]
AB  - MicroRNAs (miRNAs) are a class of small noncoding RNAs that are only 21-25 nt 
      long. Many studies have shown that miRNA dysfunction is closely related to the 
      occurrence and development of diseases. By combining with the 3' noncoding region 
      of target gene mRNA, miRNAs can mediate the degradation or translation inhibition 
      of mRNA and exert a powerful regulation effect on gene expression at the 
      posttranscriptional level, mainly inhibiting the translation or degradation of 
      targets. Therefore, they are a class of molecules that play a negative regulatory 
      role. Current studies have found that miR-16 is closely related to the occurrence 
      of several autoimmune diseases. Studies have reported that miR-16 participates in 
      the occurrence and development of rheumatoid arthritis, systemic lupus 
      erythematosus, ankylosing spondylitis, inflammatory bowel disease, autoimmune 
      thyroid disease, juvenile idiopathic arthritis, primary Sjogren's syndrome and 
      other autoimmune diseases by regulating the expression of cytokines such as 
      TNF-alpha, IL-8, IL-6, and IL-4; regulating activin A receptor (ACVR), growth 
      differentiation factor-5 (GDF-5) and adenosine A2a receptor (A2AR) expression; 
      affecting the proliferation, differentiation of Th17 cells and Treg cells; and 
      regulating the balance between the cells. In this review, emphasis will be placed 
      on the recent progress in characterizing the roles of miR-16 in these autoimmune 
      diseases.
CI  - Copyright (c) 2019 The Authors. Published by Elsevier Masson SAS.. All rights 
      reserved.
FAU - Yan, Lan
AU  - Yan L
AD  - Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State 
      Administration of Traditional Chinese Medicine, Medical College of China Three 
      Gorges University, Yichang, Hubei, 443002, China.
FAU - Liang, Mingge
AU  - Liang M
AD  - Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State 
      Administration of Traditional Chinese Medicine, Medical College of China Three 
      Gorges University, Yichang, Hubei, 443002, China.
FAU - Hou, Xiaoqiang
AU  - Hou X
AD  - Institute of Rheumatology, The First College of Clinical Medical Sciences, China 
      Three Gorges University, Yichang, Hubei, 443003, China.
FAU - Zhang, Yiwen
AU  - Zhang Y
AD  - Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State 
      Administration of Traditional Chinese Medicine, Medical College of China Three 
      Gorges University, Yichang, Hubei, 443002, China.
FAU - Zhang, Haoran
AU  - Zhang H
AD  - Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State 
      Administration of Traditional Chinese Medicine, Medical College of China Three 
      Gorges University, Yichang, Hubei, 443002, China.
FAU - Guo, Zhe
AU  - Guo Z
AD  - Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State 
      Administration of Traditional Chinese Medicine, Medical College of China Three 
      Gorges University, Yichang, Hubei, 443002, China.
FAU - Jinyu, Ji
AU  - Jinyu J
AD  - Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State 
      Administration of Traditional Chinese Medicine, Medical College of China Three 
      Gorges University, Yichang, Hubei, 443002, China.
FAU - Feng, Zhitao
AU  - Feng Z
AD  - Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State 
      Administration of Traditional Chinese Medicine, Medical College of China Three 
      Gorges University, Yichang, Hubei, 443002, China; Institute of Rheumatology, The 
      First College of Clinical Medical Sciences, China Three Gorges University, 
      Yichang, Hubei, 443003, China; School of Medicine, Jinan University, Guangzhou 
      Guangdong, 510632, China. Electronic address: fengzhitao2008@126.com.
FAU - Mei, Zhigang
AU  - Mei Z
AD  - Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State 
      Administration of Traditional Chinese Medicine, Medical College of China Three 
      Gorges University, Yichang, Hubei, 443002, China. Electronic address: 
      meizhigang@ctgu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190216
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (MIRN16 microRNA, human)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Animals
MH  - Arthritis, Rheumatoid/genetics/immunology/metabolism
MH  - Autoimmune Diseases/genetics/*immunology/*metabolism
MH  - Humans
MH  - Lupus Erythematosus, Systemic/genetics/immunology/metabolism
MH  - MicroRNAs/*physiology
MH  - Sjogren's Syndrome/genetics/immunology/metabolism
MH  - T-Lymphocytes, Regulatory/immunology/metabolism
MH  - Th17 Cells/immunology/metabolism
OTO - NOTNLM
OT  - Autoimmune
OT  - Autoimmune diseases
OT  - miR-16
EDAT- 2019/02/20 06:00
MHDA- 2019/07/23 06:00
CRDT- 2019/02/20 06:00
PHST- 2018/11/12 00:00 [received]
PHST- 2019/01/06 00:00 [revised]
PHST- 2019/01/15 00:00 [accepted]
PHST- 2019/02/20 06:00 [pubmed]
PHST- 2019/07/23 06:00 [medline]
PHST- 2019/02/20 06:00 [entrez]
AID - S0753-3322(18)38020-X [pii]
AID - 10.1016/j.biopha.2019.01.044 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2019 Apr;112:108583. doi: 10.1016/j.biopha.2019.01.044. Epub 
      2019 Feb 16.