PMID- 30781283
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1744-8417 (Electronic)
IS  - 1744-6651 (Linking)
VI  - 4
IP  - 4
DP  - 2009 Jul
TI  - Multiple endocrine neoplasia type 1.
PG  - 371-388
LID - 10.1586/eem.09.22 [doi]
AB  - Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal-dominant inherited 
      tumor syndrome characterized by hyperplasia and/or tumors in the parathyroid 
      glands, the pancreatic islets, the anterior pituitary and adrenal glands, as well 
      as neuroendocrine tumors in the thymus, lungs and stomach, and tumors in 
      nonendocrine tissues. In 1997, the responsible MEN1 gene was identified as a 
      tumor-suppressor gene and its product was named menin. In this review, guidelines 
      for early diagnosis, including MEN1 gene mutation analysis, and treatment, 
      including periodic clinical monitoring, have been formulated, enabling 
      improvement of life expectancy and quality of life. Identification of 
      menin-interacting proteins has provided new insights into the function of menin, 
      notably involving regulation of gene transcription related to proliferation and 
      apoptosis, genome stability and DNA repair, and endocrine/metabolic homeostasis. 
      In the near future, target-directed intervention may prevent or delay the onset 
      of MEN 1-related tumors.
FAU - Lips, Cornelis Jm
AU  - Lips CJ
AD  - a University Medical Center Utrecht, Department of Internal Medicine, 
      Wassenaarseweg 109, 2596 CN The Hague, The Netherlands. lips05@zonnet.nl.
FAU - Dreijerink, Koen
AU  - Dreijerink K
AD  - b University Medical Center Utrecht, Department of Internal Medicine, F02.126, PO 
      Box 85500, 3508 GA, Utrecht, The Netherlands. k.m.a.dreijerink@umcutrecht.nl.
FAU - Links, Thera P
AU  - Links TP
AD  - c University Medical Center Groningen, Department of Internal Medicine, PO Box 
      30001, 9700 RB Groningen, The Netherlands. t.p.links@int.umcg.nl.
FAU - Hoppener, Jo Wm
AU  - Hoppener JW
AD  - d Department of Metabolic and Endocrine Diseases, PO Box 85090, 3508 AB Utrecht. 
      j.w.m.hoeppener@umcutrecht.nl.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Expert Rev Endocrinol Metab
JT  - Expert review of endocrinology & metabolism
JID - 101278293
OTO - NOTNLM
OT  - DNA diagnosis
OT  - MEN 1
OT  - genetic testing
OT  - menin
OT  - multiple endocrine neoplasia type 1
OT  - mutation analysis
OT  - periodic clinical monitoring
OT  - presymptomatic treatment
EDAT- 2009/07/01 00:00
MHDA- 2009/07/01 00:01
CRDT- 2019/02/21 06:00
PHST- 2019/02/21 06:00 [entrez]
PHST- 2009/07/01 00:00 [pubmed]
PHST- 2009/07/01 00:01 [medline]
AID - 10.1586/eem.09.22 [doi]
PST - ppublish
SO  - Expert Rev Endocrinol Metab. 2009 Jul;4(4):371-388. doi: 10.1586/eem.09.22.