PMID- 30781350
OWN - NLM
STAT- MEDLINE
DCOM- 20190501
LR  - 20220409
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 11
IP  - 2
DP  - 2019 Feb 15
TI  - Targeting the Zinc Transporter ZIP7 in the Treatment of Insulin Resistance and 
      Type 2 Diabetes.
LID - 10.3390/nu11020408 [doi]
LID - 408
AB  - Type 2 diabetes mellitus (T2DM) is a disease associated with dysfunctional 
      metabolic processes that lead to abnormally high levels of blood glucose. 
      Preceding the development of T2DM is insulin resistance (IR), a disorder 
      associated with suppressed or delayed responses to insulin. The effects of this 
      response are predominately mediated through aberrant cell signalling processes 
      and compromised glucose uptake into peripheral tissue including adipose, liver 
      and skeletal muscle. Moreover, a major factor considered to be the cause of IR is 
      endoplasmic reticulum (ER) stress. This subcellular organelle plays a pivotal 
      role in protein folding and processes that increase ER stress, leads to 
      maladaptive responses that result in cell death. Recently, zinc and the proteins 
      that transport this metal ion have been implicated in the ER stress response. 
      Specifically, the ER-specific zinc transporter ZIP7, coined the "gate-keeper" of 
      zinc release from the ER into the cytosol, was shown to be essential for 
      maintaining ER homeostasis in intestinal epithelium and myeloid leukaemia cells. 
      Moreover, ZIP7 controls essential cell signalling pathways similar to insulin and 
      activates glucose uptake in skeletal muscle. Accordingly, ZIP7 may be essential 
      for the control of ER localized zinc and mechanisms that disrupt this process may 
      lead to ER-stress and contribute to IR. Accordingly, understanding the mechanisms 
      of ZIP7 action in the context of IR may provide opportunities to develop novel 
      therapeutic options to target this transporter in the treatment of IR and 
      subsequent T2DM.
FAU - Adulcikas, John
AU  - Adulcikas J
AD  - College of Health and Medicine, School of Health Sciences, University of 
      Tasmania, TAS 7005, Australia. johna6@utas.edu.au.
FAU - Sonda, Sabrina
AU  - Sonda S
AD  - College of Health and Medicine, School of Health Sciences, University of 
      Tasmania, TAS 7005, Australia. sabrina.sonda@utas.edu.au.
FAU - Norouzi, Shaghayegh
AU  - Norouzi S
AD  - College of Health and Medicine, School of Health Sciences, University of 
      Tasmania, TAS 7005, Australia. shaghayeg.norouzi@utas.edu.au.
FAU - Sohal, Sukhwinder Singh
AU  - Sohal SS
AD  - College of Health and Medicine, School of Health Sciences, University of 
      Tasmania, TAS 7005, Australia. sukhwinder.sohal@utas.edu.au.
FAU - Myers, Stephen
AU  - Myers S
AUID- ORCID: 0000-0003-4793-3820
AD  - College of Health and Medicine, School of Health Sciences, University of 
      Tasmania, TAS 7005, Australia. Stephen.myers@utas.edu.au.
LA  - eng
GR  - 172/Clifford Graig Medical Research Trust Grant/
PT  - Journal Article
PT  - Review
DEP - 20190215
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Cation Transport Proteins)
RN  - 0 (SLC39A7 protein, human)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Cation Transport Proteins/*physiology
MH  - Diabetes Mellitus, Type 2/drug therapy/*metabolism
MH  - Endoplasmic Reticulum Stress/physiology
MH  - Humans
MH  - Insulin Resistance/*physiology
MH  - Signal Transduction/physiology
MH  - Zinc/*metabolism
PMC - PMC6412268
OTO - NOTNLM
OT  - ZIP7
OT  - endoplasmic reticulum stress
OT  - insulin resistance
OT  - type 2 diabetes
OT  - zinc
OT  - zinc transporters
COIS- The authors declare no conflict of interest.
EDAT- 2019/02/20 06:00
MHDA- 2019/05/02 06:00
PMCR- 2019/02/01
CRDT- 2019/02/21 06:00
PHST- 2018/12/20 00:00 [received]
PHST- 2019/01/13 00:00 [revised]
PHST- 2019/02/12 00:00 [accepted]
PHST- 2019/02/21 06:00 [entrez]
PHST- 2019/02/20 06:00 [pubmed]
PHST- 2019/05/02 06:00 [medline]
PHST- 2019/02/01 00:00 [pmc-release]
AID - nu11020408 [pii]
AID - nutrients-11-00408 [pii]
AID - 10.3390/nu11020408 [doi]
PST - epublish
SO  - Nutrients. 2019 Feb 15;11(2):408. doi: 10.3390/nu11020408.