PMID- 30782532
OWN - NLM
STAT- MEDLINE
DCOM- 20200102
LR  - 20200102
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 172
DP  - 2019 May
TI  - Developmental exposure to a very low dose of bisphenol A induces persistent islet 
      insulin hypersecretion in Fischer 344 rat offspring.
PG  - 127-136
LID - S0013-9351(19)30084-2 [pii]
LID - 10.1016/j.envres.2019.02.009 [doi]
AB  - BACKGROUND: In children with obesity, accentuated insulin secretion has been 
      coupled with development of type 2 diabetes mellitus (T2DM). Bisphenol A (BPA) is 
      a chemical with endocrine- and metabolism-disrupting properties which can be 
      measured in a majority of the population. Exposure to BPA has been associated 
      with the development of metabolic diseases including T2DM. OBJECTIVE: The aim of 
      this study was to investigate if exposure early in life to an environmentally 
      relevant low dose of BPA causes insulin hypersecretion in rat offspring. METHODS: 
      Pregnant Fischer 344 rats were exposed to 0.5 (BPA0.5) or 50 (BPA50) microg BPA/kg 
      BW/day via drinking water from gestational day 3.5 until postnatal day 22. 
      Pancreata from dams and 5- and 52-week-old offspring were procured and islets 
      were isolated by collagenase digestion. Glucose-stimulated insulin secretion and 
      insulin content in the islets were determined by ELISA. RESULTS: Basal (5.5 mM 
      glucose) islet insulin secretion was not affected by BPA exposure. However, 
      stimulated (11 mM glucose) insulin secretion was enhanced by about 50% in islets 
      isolated from BPA0.5-exposed 5- and 52-week-old female and male offspring and by 
      80% in islets from dams, compared with control. In contrast, the higher dose, 
      BPA50, reduced stimulated insulin secretion by 40% in both 5- and 52-week-old 
      female and male offspring and dams, compared with control. CONCLUSION: A BPA 
      intake 8 times lower than the European Food Safety Authority's (EFSA's) current 
      tolerable daily intake (TDI) of 4 microg/kg BW/day of BPA delivered via drinking 
      water during gestation and early development causes islet insulin hypersecretion 
      in rat offspring up to one year after exposure. The effects of BPA exposure on 
      the endocrine pancreas may promote the development of metabolic disease including 
      T2DM.
CI  - Copyright (c) 2019 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Manukyan, Levon
AU  - Manukyan L
AD  - Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden. 
      Electronic address: levon.manukyan@angstrom.uu.se.
FAU - Dunder, Linda
AU  - Dunder L
AD  - Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala 
      University, Uppsala, Sweden. Electronic address: linda.dunder@medsci.uu.se.
FAU - Lind, P Monica
AU  - Lind PM
AD  - Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala 
      University, Uppsala, Sweden. Electronic address: monica.lind@medsci.uu.se.
FAU - Bergsten, Peter
AU  - Bergsten P
AD  - Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden; 
      Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. 
      Electronic address: peter.bergsten@mcb.uu.se.
FAU - Lejonklou, Margareta H
AU  - Lejonklou MH
AD  - Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala 
      University, Uppsala, Sweden. Electronic address: margareta.halin@medsci.uu.se.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190208
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Insulin)
RN  - 0 (Phenols)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Animals
MH  - *Benzhydryl Compounds/toxicity
MH  - Embryo, Mammalian/drug effects
MH  - *Environmental Pollutants/toxicity
MH  - Female
MH  - Humans
MH  - *Insulin/metabolism
MH  - Islets of Langerhans
MH  - Male
MH  - *Phenols/toxicity
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Inbred F344
OTO - NOTNLM
OT  - Bisphenol A
OT  - Endocrine disruptor
OT  - Fischer 344 rats
OT  - Insulin hypersecretion
OT  - Islets of Langerhans
EDAT- 2019/02/21 06:00
MHDA- 2020/01/03 06:00
CRDT- 2019/02/21 06:00
PHST- 2018/11/01 00:00 [received]
PHST- 2019/01/22 00:00 [revised]
PHST- 2019/02/07 00:00 [accepted]
PHST- 2019/02/21 06:00 [pubmed]
PHST- 2020/01/03 06:00 [medline]
PHST- 2019/02/21 06:00 [entrez]
AID - S0013-9351(19)30084-2 [pii]
AID - 10.1016/j.envres.2019.02.009 [doi]
PST - ppublish
SO  - Environ Res. 2019 May;172:127-136. doi: 10.1016/j.envres.2019.02.009. Epub 2019 
      Feb 8.