PMID- 30783031
OWN - NLM
STAT- MEDLINE
DCOM- 20190704
LR  - 20190704
IS  - 1423-0259 (Electronic)
IS  - 0030-3747 (Linking)
VI  - 62
IP  - 1
DP  - 2019
TI  - Measurement of Structural Parameters of the Lamina Cribrosa in Primary Open-Angle 
      Glaucoma and Chronic Primary Angle-Closure Glaucoma by Optical Coherence 
      Tomography and Its Correlations with Ocular Parameters.
PG  - 36-45
LID - 10.1159/000496558 [doi]
AB  - PURPOSE: To measure lamina cribrosa thickness (LCT) and anterior lamina cribrosa 
      surface depth (ALCSD) in primary open-angle glaucoma (POAG), chronic primary 
      angle-closure glaucoma (CPACG), and control patients using spectral-domain 
      optical coherence tomography (SD-OCT) and examine its association with relevant 
      ocular parameters. METHODS: In this cross-sectional study, 61 healthy volunteers 
      (61 eyes), 65 POAG patients (65 eyes), and 55 CPACG patients (55 eyes) were 
      recruited to obtain radial B-scans of the optic nerve head by way of enhanced 
      depth imaging using Heidelberg SD-OCT. The obtained LCT and ALCSD were compared 
      among the control, POAG, and CPACG groups. In addition, we evaluated the 
      relationships of mean lamina cribrosa (LC) parameters with visual field (VF) mean 
      deviation (MD), retinal nerve fiber layer (RNFL) thickness, intraocular pressure 
      (IOP), and axial length. RESULTS: The mean LCT of CPACG eyes was greater than 
      that of POAG eyes (p = 0.003), but less than that of normal eyes (p < 0.001). The 
      mean ALCSD of POAG and CPACG eyes was greater than that of normal control eyes 
      (both p < 0.001). However, the mean ALCSD showed no significant difference 
      between the POAG and CPACG groups (p = 0.073). Among all eyes, lower MD and 
      thinner RNFL thickness were associated with a deeper and thinner LC (all p < 
      0.001). CONCLUSION: LCT is thinner in POAG compared to CPACG eyes. This is 
      compatible with less deformation and compression of the LC in CPACG eyes, 
      implying that the mechanisms of glaucomatous damage are different between POAG 
      and CPACG eyes. Furthermore, VF MD and RNFL thickness were related to LCT and 
      ALCSD in all patients.
CI  - (c) 2019 S. Karger AG, Basel.
FAU - Hao, Linlin
AU  - Hao L
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangzhou, China.
AD  - Department of Ophthalmology, The Second Hospital of Shandong University, Jinan, 
      China.
FAU - Xiao, Hui
AU  - Xiao H
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangzhou, China.
FAU - Gao, Xue
AU  - Gao X
AD  - Department of Ophthalmology, The Second Hospital of Shandong University, Jinan, 
      China.
FAU - Xu, Xiaoyu
AU  - Xu X
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangzhou, China.
FAU - Liu, Xing
AU  - Liu X
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangzhou, China, drliuxing@163.com.
LA  - eng
PT  - Journal Article
DEP - 20190215
PL  - Switzerland
TA  - Ophthalmic Res
JT  - Ophthalmic research
JID - 0267442
SB  - IM
MH  - Adult
MH  - Aged
MH  - Axial Length, Eye/pathology
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - Glaucoma, Angle-Closure/*pathology/physiopathology
MH  - Glaucoma, Open-Angle/*pathology/physiopathology
MH  - Humans
MH  - Intraocular Pressure/physiology
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/pathology
MH  - Optic Disk/diagnostic imaging/*pathology
MH  - Retinal Ganglion Cells/pathology
MH  - Tomography, Optical Coherence/methods
MH  - Visual Fields/physiology
OTO - NOTNLM
OT  - Chronic primary angle-closure glaucoma
OT  - Lamina cribrosa
OT  - Primary open-angle glaucoma
OT  - Spectral-domain optical coherence tomography
EDAT- 2019/02/21 06:00
MHDA- 2019/07/05 06:00
CRDT- 2019/02/21 06:00
PHST- 2018/08/22 00:00 [received]
PHST- 2018/12/28 00:00 [accepted]
PHST- 2019/02/21 06:00 [pubmed]
PHST- 2019/07/05 06:00 [medline]
PHST- 2019/02/21 06:00 [entrez]
AID - 000496558 [pii]
AID - 10.1159/000496558 [doi]
PST - ppublish
SO  - Ophthalmic Res. 2019;62(1):36-45. doi: 10.1159/000496558. Epub 2019 Feb 15.