PMID- 30783437
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 17
IP  - 3
DP  - 2019 Mar
TI  - The activation of BDNF reduced inflammation in a spinal cord injury model by 
      TrkB/p38 MAPK signaling.
PG  - 1688-1696
LID - 10.3892/etm.2018.7109 [doi]
AB  - The aim of the present study was to investigate the pro-inflammation effects of 
      brain-derived neurotrophic factor (BDNF) signaling in promoting inflammation 
      following spinal cord injury (SCI) in rats. Reverse transcription-quantitative 
      polymerase chain reaction was used to detect the expression of BDNF in SCI rats. 
      The Basso, Beattie and Bresnahan (BBB) test was used and the water content of 
      spinal cord were assessed to determine the effects of BDNF on SCI. BDNF 
      expression was increased in SCI rats. In an in vitro model, overexpression of 
      BDNF induced the protein expression of tyrosine kinase receptor B (TrkB) and 
      suppressed that of phosphorylated (p-)p38, and reduced inflammation, as indicated 
      by tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, IL-18, inducible 
      nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 levels. Conversely, the 
      TrkB inhibitor ANA-12 suppressed the protein expression of TrkB and induced that 
      of p-p38, and promoted inflammation (as indicated by TNF-alpha, IL-1beta, IL-6, IL-18, 
      iNOS and COX-2 levels) in an in vitro model of SCI by BDNF overexpression. In 
      addition, the p38 inhibitor TA-0, suppressed p38 protein expression and reduced 
      inflammation in an in vitro model of SCI by BDNF overexpression. Together, these 
      data suggest that the pro-inflammation effects of BDNF/TrkB promoted inflammation 
      in SCI through p38 signaling in rats.
FAU - Liang, Jiedong
AU  - Liang J
AD  - Department of Orthopedics, China Three Gorges University, Yichang, Hubei 443000, 
      P.R. China.
FAU - Deng, Gui
AU  - Deng G
AD  - Department of Orthopedics, China Three Gorges University, Yichang, Hubei 443000, 
      P.R. China.
FAU - Huang, He
AU  - Huang H
AD  - Department of Orthopedics, China Three Gorges University, Yichang, Hubei 443000, 
      P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20181218
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC6364215
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - inflammation
OT  - p38
OT  - spinal cord injury
OT  - tyrosine kinase receptor B
EDAT- 2019/02/21 06:00
MHDA- 2019/02/21 06:01
PMCR- 2018/12/18
CRDT- 2019/02/21 06:00
PHST- 2018/03/30 00:00 [received]
PHST- 2018/07/20 00:00 [accepted]
PHST- 2019/02/21 06:00 [entrez]
PHST- 2019/02/21 06:00 [pubmed]
PHST- 2019/02/21 06:01 [medline]
PHST- 2018/12/18 00:00 [pmc-release]
AID - ETM-0-0-7109 [pii]
AID - 10.3892/etm.2018.7109 [doi]
PST - ppublish
SO  - Exp Ther Med. 2019 Mar;17(3):1688-1696. doi: 10.3892/etm.2018.7109. Epub 2018 Dec 
      18.