PMID- 30783767
OWN - NLM
STAT- MEDLINE
DCOM- 20190624
LR  - 20190624
IS  - 1432-069X (Electronic)
IS  - 0340-3696 (Linking)
VI  - 311
IP  - 3
DP  - 2019 Apr
TI  - Activators of SIRT1 in wound repair: an animal model study.
PG  - 193-201
LID - 10.1007/s00403-019-01901-4 [doi]
AB  - Caloric restriction (CR) and resveratrol activate SIRT1 and induce 
      anti-inflammatory and antioxidant properties. We perform excisional lesion on the 
      dorsum of four groups anesthetized animals: ad libitum-AL diet, AL diet with 
      topical application of 2% resveratrol-Rv, 30% calorie restricted, and finally 30% 
      calorie restricted with 2% resveratrol and we examine CR and Rv effects in wound 
      repair. Restricted animals remained with CR for 31 days. The lesion was performed 
      on day 18 of CR, and resveratrol application was started on day 19. Lesion 
      samples were then collected on days 3 and 10 of treatment for structural, 
      morphometric, and protein analyses. Our results showed that CR and Rv group as 
      well as R group had enhanced numbers of blood vessels, VEGF, fibroblast, 
      birefringent collagen fiber areas in the lesion. We conclude that effects in 
      wound repair suggests that both CR and resveratrol may modulate angiogenesis, 
      fibroplasia, and collagenesis, which could be ascribed to the action of SIRT1.
FAU - Christovam, Ana Cristina
AU  - Christovam AC
AD  - Graduate Program in Biomedical Sciences, Centro Universitario da Fundacao 
      Herminio Ometto, FHO, Av. Maximiliano Barutto 500, Jardim Universitario, Araras, 
      SP, 13607-339, Brazil.
FAU - Theodoro, Viviane
AU  - Theodoro V
AD  - Graduate Program in Biomedical Sciences, Centro Universitario da Fundacao 
      Herminio Ometto, FHO, Av. Maximiliano Barutto 500, Jardim Universitario, Araras, 
      SP, 13607-339, Brazil.
FAU - Mendonca, Fernanda Aparecida Sampaio
AU  - Mendonca FAS
AD  - Graduate Program in Biomedical Sciences, Centro Universitario da Fundacao 
      Herminio Ometto, FHO, Av. Maximiliano Barutto 500, Jardim Universitario, Araras, 
      SP, 13607-339, Brazil.
FAU - Esquisatto, Marcelo Augusto Marretto
AU  - Esquisatto MAM
AD  - Graduate Program in Biomedical Sciences, Centro Universitario da Fundacao 
      Herminio Ometto, FHO, Av. Maximiliano Barutto 500, Jardim Universitario, Araras, 
      SP, 13607-339, Brazil.
FAU - Dos Santos, Glaucia Maria Tech
AU  - Dos Santos GMT
AD  - Graduate Program in Biomedical Sciences, Centro Universitario da Fundacao 
      Herminio Ometto, FHO, Av. Maximiliano Barutto 500, Jardim Universitario, Araras, 
      SP, 13607-339, Brazil.
FAU - do Amaral, Maria Esmeria Corezola
AU  - do Amaral MEC
AUID- ORCID: 0000-0001-5128-2202
AD  - Graduate Program in Biomedical Sciences, Centro Universitario da Fundacao 
      Herminio Ometto, FHO, Av. Maximiliano Barutto 500, Jardim Universitario, Araras, 
      SP, 13607-339, Brazil. esmeria@uniararas.br.
LA  - eng
PT  - Journal Article
DEP - 20190219
PL  - Germany
TA  - Arch Dermatol Res
JT  - Archives of dermatological research
JID - 8000462
RN  - 0 (Enzyme Activators)
RN  - 9007-34-5 (Collagen)
RN  - EC 3.5.1.- (Sirt1 protein, rat)
RN  - EC 3.5.1.- (Sirtuin 1)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Animals
MH  - *Caloric Restriction
MH  - Collagen/metabolism
MH  - Disease Models, Animal
MH  - Enzyme Activation
MH  - Enzyme Activators/*pharmacology
MH  - Fibrosis
MH  - Male
MH  - Rats, Wistar
MH  - Resveratrol/*pharmacology
MH  - Signal Transduction/drug effects
MH  - Sirtuin 1/*metabolism
MH  - Skin/*drug effects/enzymology/injuries/pathology
MH  - Time Factors
MH  - Wound Healing/*drug effects
MH  - Wounds, Penetrating/enzymology/pathology/*therapy
OTO - NOTNLM
OT  - Caloric restriction
OT  - Collagen
OT  - Resveratrol
OT  - SIRT1
OT  - Skin
OT  - Tissue repair
EDAT- 2019/02/21 06:00
MHDA- 2019/06/25 06:00
CRDT- 2019/02/21 06:00
PHST- 2018/11/27 00:00 [received]
PHST- 2019/02/15 00:00 [accepted]
PHST- 2019/02/13 00:00 [revised]
PHST- 2019/02/21 06:00 [pubmed]
PHST- 2019/06/25 06:00 [medline]
PHST- 2019/02/21 06:00 [entrez]
AID - 10.1007/s00403-019-01901-4 [pii]
AID - 10.1007/s00403-019-01901-4 [doi]
PST - ppublish
SO  - Arch Dermatol Res. 2019 Apr;311(3):193-201. doi: 10.1007/s00403-019-01901-4. Epub 
      2019 Feb 19.