PMID- 30784761
OWN - NLM
STAT- MEDLINE
DCOM- 20190730
LR  - 20190730
IS  - 1934-8800 (Electronic)
IS  - 0163-6383 (Linking)
VI  - 54
DP  - 2019 Feb
TI  - Exploratory behavior and developmental skill acquisition in infants with Down 
      syndrome.
PG  - 140-150
LID - S0163-6383(18)30178-4 [pii]
LID - 10.1016/j.infbeh.2019.02.002 [doi]
AB  - Infants learn about objects by exploring them. Typically developing infants 
      actively explore objects through visual, manual, and oral modalities. Attenuated 
      exploratory behavior has been observed in various neurodevelopmental disorders, 
      including Down syndrome (DS), presumably limiting learning options. However, a 
      direct link between exploration and overall developmental functioning has not 
      been characterized. This study used a Latent Profile Analysis framework to 
      examine within-syndrome variability in exploratory behavior in infants with DS 
      and the developmental correlates of different exploratory behavior profiles. 
      Participants were 45 infants with DS (CA = 9.58 months; SD = 3.62) who completed 
      an object exploration activity and the Bayley Scales of Infant Development-III 
      (BSID-III; Bayley, 2006). Exploration behavior was coded for the percentage of 
      time engaged in visual, manual, and oral exploration. Results indicated that a 
      2-profile solution provided the best model fit for exploratory behavior, yielding 
      profiles that represented either an Active (57.78% of the sample) or a Passive 
      Exploratory (42.22% of the sample) profile. The Active Exploratory profile was 
      associated with significantly higher age equivalent scores on the BSID-III 
      Cognitive, Communication, and Motor domains than the Passive Exploratory profile. 
      Other factors, such as sex and biomedical risk factors, were not associated with 
      exploratory profiles. These findings offer a more nuanced understanding of early 
      within-syndrome heterogeneity in DS, and demonstrate that impoverished early 
      exploratory behavior may serve as an important indicator of increased risk for 
      more pronounced developmental delays in DS.
CI  - Copyright (c) 2019. Published by Elsevier Inc.
FAU - Fidler, Deborah J
AU  - Fidler DJ
AD  - Colorado State University, United States. Electronic address: 
      Deborah.Fidler@colostate.edu.
FAU - Schworer, Emily
AU  - Schworer E
AD  - Colorado State University, United States.
FAU - Prince, Mark A
AU  - Prince MA
AD  - Colorado State University, United States.
FAU - Will, Elizabeth A
AU  - Will EA
AD  - University of South Carolina, United States.
FAU - Needham, Amy W
AU  - Needham AW
AD  - Vanderbilt University, United States.
FAU - Daunhauer, Lisa A
AU  - Daunhauer LA
AD  - Colorado State University, United States.
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20190219
PL  - United States
TA  - Infant Behav Dev
JT  - Infant behavior & development
JID - 7806016
MH  - Adult
MH  - Child Development/*physiology
MH  - Developmental Disabilities/diagnosis/psychology
MH  - Down Syndrome/diagnosis/*psychology
MH  - Exploratory Behavior/*physiology
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Neurodevelopmental Disorders/diagnosis/psychology
MH  - Psychomotor Performance/*physiology
OTO - NOTNLM
OT  - Behavioral phenotype
OT  - Down syndrome
OT  - Exploratory behavior
OT  - Latent profile analysis
EDAT- 2019/02/21 06:00
MHDA- 2019/07/31 06:00
CRDT- 2019/02/21 06:00
PHST- 2018/06/22 00:00 [received]
PHST- 2019/02/06 00:00 [revised]
PHST- 2019/02/06 00:00 [accepted]
PHST- 2019/02/21 06:00 [pubmed]
PHST- 2019/07/31 06:00 [medline]
PHST- 2019/02/21 06:00 [entrez]
AID - S0163-6383(18)30178-4 [pii]
AID - 10.1016/j.infbeh.2019.02.002 [doi]
PST - ppublish
SO  - Infant Behav Dev. 2019 Feb;54:140-150. doi: 10.1016/j.infbeh.2019.02.002. Epub 
      2019 Feb 19.