PMID- 30785231
OWN - NLM
STAT- MEDLINE
DCOM- 20201007
LR  - 20201007
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Linking)
VI  - 41
IP  - 3
DP  - 2019 Mar
TI  - Patterns of care and survival outcomes for laryngeal small cell cancer.
PG  - 722-729
LID - 10.1002/hed.25430 [doi]
AB  - BACKGROUND: To determine practice patterns and outcomes of laryngeal small cell 
      cancer (LSCC) across the United States. METHODS: Patients with LSCC were 
      identified in the National Cancer Database. Overall survival (OS) was compared 
      with Kaplan-Meier analysis and Cox regression. RESULTS: From 2004 to 2014, the 
      5-year OS for early stage (n = 47), locally advanced stage (n = 133), and 
      metastatic disease (n = 53) was 34%, 26%, and 9%, respectively. Chemoradiation 
      was given in 66% of cases. Chemotherapy was less likely given in early stage 
      disease (P = .001), and definitive radiation was less likely given in metastatic 
      disease (P < .001). Definitive radiation improved median OS in locally advanced 
      LSCC (20 vs. 7 months, log-rank P = .04). In multivariable modeling, radiation 
      dose >/=40 Gy was associated with better OS (P < .001). CONCLUSION: Chemoradiation 
      was the most common practice for treating locally advanced LSCC, and radiation 
      dose >/=40 Gy was associated with improved OS.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Lin, Alexander J
AU  - Lin AJ
AUID- ORCID: 0000-0002-6971-7187
AD  - Department of Radiation Oncology, Washington University School of Medicine, St. 
      Louis, Missouri.
FAU - Gabani, Prashant
AU  - Gabani P
AD  - Department of Radiation Oncology, Washington University School of Medicine, St. 
      Louis, Missouri.
FAU - Fischer-Valuck, Ben
AU  - Fischer-Valuck B
AD  - Department of Radiation Oncology, Washington University School of Medicine, St. 
      Louis, Missouri.
FAU - Rudra, Soumon
AU  - Rudra S
AD  - Department of Radiation Oncology, Washington University School of Medicine, St. 
      Louis, Missouri.
FAU - Gay, Hiram
AU  - Gay H
AD  - Department of Radiation Oncology, Washington University School of Medicine, St. 
      Louis, Missouri.
FAU - Daly, Mackenzie
AU  - Daly M
AD  - Department of Radiation Oncology, Washington University School of Medicine, St. 
      Louis, Missouri.
FAU - Oppelt, Peter
AU  - Oppelt P
AD  - Division of Hematology and Oncology, Department of Internal Medicine, Washington 
      University School of Medicine, St. Louis, Missouri.
FAU - Jackson, Ryan
AU  - Jackson R
AD  - Division of Head and Neck Oncology Surgery, Department of Otolaryngology, 
      Washington University School of Medicine, St. Louis, Missouri.
FAU - Rich, Jason
AU  - Rich J
AD  - Division of Head and Neck Oncology Surgery, Department of Otolaryngology, 
      Washington University School of Medicine, St. Louis, Missouri.
FAU - Paniello, Randal
AU  - Paniello R
AD  - Division of Head and Neck Oncology Surgery, Department of Otolaryngology, 
      Washington University School of Medicine, St. Louis, Missouri.
FAU - Zevallos, Jose
AU  - Zevallos J
AUID- ORCID: 0000-0002-9111-6767
AD  - Division of Head and Neck Oncology Surgery, Department of Otolaryngology, 
      Washington University School of Medicine, St. Louis, Missouri.
FAU - Adkins, Douglas
AU  - Adkins D
AD  - Division of Hematology and Oncology, Department of Internal Medicine, Washington 
      University School of Medicine, St. Louis, Missouri.
FAU - Thorstad, Wade
AU  - Thorstad W
AD  - Department of Radiation Oncology, Washington University School of Medicine, St. 
      Louis, Missouri.
LA  - eng
PT  - Journal Article
DEP - 20181210
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Small Cell/*mortality/pathology/*therapy
MH  - Chemoradiotherapy
MH  - Databases, Factual
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Laryngeal Neoplasms/*mortality/pathology/*therapy
MH  - Male
MH  - Middle Aged
MH  - *Practice Patterns, Physicians'
MH  - Proportional Hazards Models
MH  - Survival Rate
MH  - Treatment Outcome
MH  - United States
MH  - Young Adult
OTO - NOTNLM
OT  - chemotherapy
OT  - head and neck
OT  - neuroendocrine cancer
OT  - radiation
OT  - surgery
EDAT- 2019/02/21 06:00
MHDA- 2020/10/08 06:00
CRDT- 2019/02/21 06:00
PHST- 2018/04/15 00:00 [received]
PHST- 2018/07/19 00:00 [revised]
PHST- 2018/09/21 00:00 [accepted]
PHST- 2019/02/21 06:00 [entrez]
PHST- 2019/02/21 06:00 [pubmed]
PHST- 2020/10/08 06:00 [medline]
AID - 10.1002/hed.25430 [doi]
PST - ppublish
SO  - Head Neck. 2019 Mar;41(3):722-729. doi: 10.1002/hed.25430. Epub 2018 Dec 10.