PMID- 30785522
OWN - NLM
STAT- MEDLINE
DCOM- 20190314
LR  - 20190314
IS  - 1678-4219 (Electronic)
IS  - 0004-2803 (Linking)
VI  - 55
IP  - 4
DP  - 2018 Oct-Dec
TI  - GASTRIC FUNDIC GLAND POLYPS: CAN HISTOLOGY BE USEFUL TO PREDICT PROTON PUMP 
      INHIBITORS USE?
PG  - 380-384
LID - S0004-28032018002400380 [pii]
LID - 10.1590/S0004-2803.201800000-82 [doi]
AB  - BACKGROUND: Fundic gland polyps allegedly increased in frequency in recent 
      decades, and had attracted great attention due to possible association with 
      prolonged proton pump inhibitor therapy. Prolonged use of this drug could cause 
      parietal cell hyperplasia, obstruction of glandular lumen and cystic dilation of 
      the gland. OBJECTIVE: This study aims to analyze clinical and pathological 
      features of fundic gland polyps in patients with and without proton pump 
      inhibitor therapy in a selected population from Brazil. METHODS: It was selected 
      a sample of 101 Brazilian patients (78 females and 23 males), from a five years 
      retrospective search of the files from a private pathology laboratory. The 
      patients had an average age of 57 years and we included patients with a 
      histological diagnosis of fundic gland polyp. The clinical data were obtained 
      from their files and all histological slides were reviewed and examined with 
      hematoxylin and eosin (HE) and Giemsa. RESULTS: Information about the use or 
      non-use of proton pump inhibitors (PPI) was obtained in 84 patient files. In 17 
      cases we could not determine if PPI were used or not. Among those in which the 
      information was available, a positive history of anti-acid therapy was observed 
      in 63 (75.0%) patients. Parietal cell hypertrophy/hyperplasia and parietal cell 
      protrusions were detected in most slides. Histological findings were identical in 
      PPI users and PPI negative patients. Helicobacter pylori infection was detected 
      in just two samples. Epithelial dysplasia or adenocarcinoma were not observed in 
      our cases. Histopathological analysis of fundic gland polyps could not 
      distinguish between PPI and non-PPI related cases. Parietal cell cytoplasmic 
      protrusions, an alleged marker of prolonged acid suppression therapy, was 
      detected in both groups. CONCLUSION: Histological features could not discriminate 
      anti-acid therapy related fundic glands polyps in our patients.
FAU - Brito, Hugo Leite de Farias
AU  - Brito HLF
AUID- ORCID: 0000-0002-3950-5124
AD  - Universidade Federal de Sergipe, Departamento de Medicina, Aracaju, SE, Brasil.
FAU - Barros, Cynthia
AU  - Barros C
AD  - Universidade Federal de Sergipe, Departamento de Medicina, Aracaju, SE, Brasil.
FAU - Freire, Marcelle Vieira
AU  - Freire MV
AD  - Universidade Federal de Sergipe, Departamento de Medicina, Aracaju, SE, Brasil.
FAU - Silva Filho, Miraldo Nascimento da
AU  - Silva Filho MND
AD  - Universidade Federal de Sergipe, Departamento de Medicina, Aracaju, SE, Brasil.
FAU - Nascimento, Tereza Virginia
AU  - Nascimento TV
AD  - Universidade Federal de Sergipe, Departamento de Medicina, Aracaju, SE, Brasil.
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Arq Gastroenterol
JT  - Arquivos de gastroenterologia
JID - 15310600R
RN  - 0 (Proton Pump Inhibitors)
RN  - Polyposis, Gastric
SB  - IM
MH  - Adenomatous Polyps/*chemically induced/*pathology
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brazil
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polyps/*chemically induced/*pathology
MH  - Proton Pump Inhibitors/*adverse effects
MH  - Retrospective Studies
MH  - Sex Factors
MH  - Stomach/*pathology
MH  - Stomach Neoplasms/*chemically induced/*pathology
MH  - Young Adult
EDAT- 2019/02/21 06:00
MHDA- 2019/03/15 06:00
CRDT- 2019/02/21 06:00
PHST- 2018/06/17 00:00 [received]
PHST- 2018/10/15 00:00 [accepted]
PHST- 2019/02/21 06:00 [entrez]
PHST- 2019/02/21 06:00 [pubmed]
PHST- 2019/03/15 06:00 [medline]
AID - S0004-28032018002400380 [pii]
AID - 10.1590/S0004-2803.201800000-82 [doi]
PST - ppublish
SO  - Arq Gastroenterol. 2018 Oct-Dec;55(4):380-384. doi: 
      10.1590/S0004-2803.201800000-82.