PMID- 30786009
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230201
IS  - 1097-4652 (Electronic)
IS  - 0021-9541 (Linking)
VI  - 234
IP  - 9
DP  - 2019 Sep
TI  - Association of vaspin rs2236242 gene variants with type 2 diabetes and obesity in 
      a Chinese population: A prospective, single-center study.
PG  - 16097-16101
LID - 10.1002/jcp.28267 [doi]
AB  - AIM: Vaspin is an adipokine separated from visceral fat tissues of obese diabetic 
      rats. This study was to investigate the association between vaspin rs2236242 gene 
      polymorphism and type 2 diabetes mellitus (T2DM) or obesity in a Chinese 
      population. MATERIALS AND METHODS: T2DM patients and nondiabetic controls were 
      recruited from Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University 
      (Shanghai, China) from May 1, 2015 to June 30, 2017. Clinicopathologic 
      characteristics were recorded and their blood samples were collected. Serum 
      vaspin levels were detected by enzyme-linked immunosorbent assay and vaspin 
      rs2236242 genotypes by tetra-amplification refractory mutation system-polymerase 
      chain reaction. RESULTS: Two hundred and ninety-nine patients with T2DM and 311 
      controls were recruited at last. The vaspin genotypes of diabetic patients were 
      distinct from nondiabetic controls (chi (2)  = 54.611, p < 0.0001). Genotyping 
      revealed that T2DM patients have a greater prevalence of A allele compared with 
      controls (61.9% vs. 42.1%, p < 0.0001). A allele was associated with an increased 
      risk of T2DM (odds ratio = 2.23, 95% confidence interval = 1.773-2.804, 
      p < 0.0001) compared with T allele. The genotype distribution did not differ 
      among nondiabetic subjects with or without obesity. The serum vaspin levels were 
      higher in T2DM patients and obese controls than the nonobese controls, however, 
      the rs2236242 was not found to be significantly related to serum vaspin levels. 
      CONCLUSIONS: Our findings showed the association between vaspin rs2236242 gene 
      variants with obesity and T2DM in a Chinese population. People with rs2236242 A 
      allele had a 2.23-fold increased risk of T2DM. These findings suggest that vaspin 
      rs2236242 may serve as a potential diagnostic and/or therapeutic targets for 
      T2DM.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Li, Ji
AU  - Li J
AD  - Department of Nephrology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan 
      University, Shanghai, People's Republic of China.
FAU - Li, Qian
AU  - Li Q
AUID- ORCID: 0000-0001-5439-7697
AD  - Department of Urology, Huai'an Second People's Hospital and The Affiliated 
      Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
FAU - Zhu, Ying-Chun
AU  - Zhu YC
AD  - Department of Nephrology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan 
      University, Shanghai, People's Republic of China.
FAU - Wang, Ya-Kun
AU  - Wang YK
AD  - Department of Nephrology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan 
      University, Shanghai, People's Republic of China.
FAU - Gao, Cong-Pu
AU  - Gao CP
AD  - Department of Nephrology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan 
      University, Shanghai, People's Republic of China.
FAU - Li, Xiao-Ying
AU  - Li XY
AD  - Department of Nephrology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan 
      University, Shanghai, People's Republic of China.
FAU - Ji, Tingting
AU  - Ji T
AD  - Department of Nephrology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan 
      University, Shanghai, People's Republic of China.
FAU - Bai, Shou-Jun
AU  - Bai SJ
AUID- ORCID: 0000-0002-3717-5053
AD  - Department of Nephrology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan 
      University, Shanghai, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20190220
PL  - United States
TA  - J Cell Physiol
JT  - Journal of cellular physiology
JID - 0050222
SB  - IM
OTO - NOTNLM
OT  - gene polymorphism
OT  - type 2 diabetes
OT  - vaspin
EDAT- 2019/02/21 06:00
MHDA- 2019/02/21 06:01
CRDT- 2019/02/21 06:00
PHST- 2018/12/30 00:00 [revised]
PHST- 2018/11/23 00:00 [received]
PHST- 2019/01/10 00:00 [accepted]
PHST- 2019/02/21 06:00 [pubmed]
PHST- 2019/02/21 06:01 [medline]
PHST- 2019/02/21 06:00 [entrez]
AID - 10.1002/jcp.28267 [doi]
PST - ppublish
SO  - J Cell Physiol. 2019 Sep;234(9):16097-16101. doi: 10.1002/jcp.28267. Epub 2019 
      Feb 20.