PMID- 30786862
OWN - NLM
STAT- MEDLINE
DCOM- 20190325
LR  - 20200225
IS  - 1471-2415 (Electronic)
IS  - 1471-2415 (Linking)
VI  - 19
IP  - 1
DP  - 2019 Feb 20
TI  - Decreased retinal nerve fiber layer thickness in patients with cerebral venous 
      thrombosis.
PG  - 57
LID - 10.1186/s12886-019-1046-9 [doi]
LID - 57
AB  - BACKGROUND: To identify thickness variations in the retinal nerve fiber layer 
      around the optic disc and macula in patients with cerebral vein thrombosis (CVT) 
      without papilledema. METHODS: This study included 28 patients with CVT diagnosis 
      and appropriate treatment. Detailed ophthalmologic examination found bilateral 
      vision 10/10, vision field test normal and fundus examination found no 
      papilledema images. The patients had macular and optic retinal nerve fiber layer 
      thickness (RNFL) measured with spectral domain-optical coherence tomography 
      (SD-OCT) (Optovue, Fremont, CA). Patients had retinal nerve fiber thickness 
      compared with a control group. RESULTS: When the effect on the macula and RNFL 
      near the optic nerve disk is investigated, there was significant thinning 
      identified in the macula inferior inner, temporal inner, superior inner and 
      temporal outer quadrants (p = 0.009, 0.001, 0.026, 0.014, respectively) and in 
      the inferior temporal quadrant of the optic nerve disk (p = 0.020) in CVT 
      patients compared to normal individuals. CONCLUSIONS: Even after appropriate 
      treatment of CVT patients, axonal loss was identified with OCT. As a result, it 
      may be important to use OCT measurements to monitor CVT treatment.
FAU - Koban, Yaran
AU  - Koban Y
AUID- ORCID: 0000-0002-4981-8001
AD  - Faculty of Medicine, Department of Ophthalmology, University of Kafkas, Merkez, 
      36100, Kars, Turkey. yarankoban@yahoo.com.au.
FAU - Ozlece, Hatice
AU  - Ozlece H
AD  - Department of Neurology, Acibadem Kayseri Hospital, Kayseri, Turkey.
FAU - Karayol, Sibel
AU  - Karayol S
AD  - Faculty of Medicine, Department of Radiology, University of Harran, Sanliurfa, 
      Turkey.
FAU - Huseyinoglu, Nergiz
AU  - Huseyinoglu N
AD  - Department of Neurology, Acibadem Kayseri Hospital, Kayseri, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20190220
PL  - England
TA  - BMC Ophthalmol
JT  - BMC ophthalmology
JID - 100967802
SB  - IM
MH  - Adult
MH  - Aged
MH  - Axons/pathology
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Intracranial Thrombosis/*pathology
MH  - Macula Lutea/pathology
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Optic Disk/pathology
MH  - Optic Nerve Diseases/*pathology
MH  - Prospective Studies
MH  - Retina/*pathology
MH  - Retinal Ganglion Cells/*pathology
MH  - Tomography, Optical Coherence/methods
MH  - Venous Thrombosis/*pathology
PMC - PMC6383271
OTO - NOTNLM
OT  - Axonal loss
OT  - Cerebral venous thrombosis
OT  - Macular thickness
OT  - Optical coherence tomography
OT  - Retinal nerve fiber layer
COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: The study adhered to the tenets of 
      the Declaration of Helsinki. It was approved by the local ethics committee 
      (Kafkas University, Human Ethics Comitteee, Kars, Turkey), and written informed 
      consent was obtained from all participants before they recruited into the study. 
      CONSENT FOR PUBLICATION: Written informed consent was obtained from the patient 
      for publication of this study and any accompanying images. COMPETING INTERESTS: 
      The authors declare that they have no competing interests. PUBLISHER'S NOTE: 
      Springer Nature remains neutral with regard to jurisdictional claims in published 
      maps and institutional affiliations.
EDAT- 2019/02/23 06:00
MHDA- 2019/03/26 06:00
PMCR- 2019/02/20
CRDT- 2019/02/22 06:00
PHST- 2017/12/23 00:00 [received]
PHST- 2019/01/21 00:00 [accepted]
PHST- 2019/02/22 06:00 [entrez]
PHST- 2019/02/23 06:00 [pubmed]
PHST- 2019/03/26 06:00 [medline]
PHST- 2019/02/20 00:00 [pmc-release]
AID - 10.1186/s12886-019-1046-9 [pii]
AID - 1046 [pii]
AID - 10.1186/s12886-019-1046-9 [doi]
PST - epublish
SO  - BMC Ophthalmol. 2019 Feb 20;19(1):57. doi: 10.1186/s12886-019-1046-9.