PMID- 30787212
OWN - NLM
STAT- MEDLINE
DCOM- 20190927
LR  - 20200309
IS  - 1884-8796 (Electronic)
IS  - 0916-8737 (Print)
IS  - 0916-8737 (Linking)
VI  - 54
IP  - 0
DP  - 2018
TI  - GABAergic and glutamatergic neurons in the brain regulate phase II of migrating 
      motor contractions in the Suncus murinus.
PG  - 91-99
LID - 10.1540/jsmr.54.91 [doi]
AB  - Gastric contractions exhibit characteristic motor patterns in the fasted state, 
      known as migrating motor contractions (MMC). MMC consist of three periodically 
      repeated phases (phase I, II and III) and are known to be regulated by hormones 
      and the autonomic and enteric nervous systems. However, the central regulation of 
      gastric contractions in the fasted state is not completely understood. Here, we 
      have examined the central effects of motilin, ghrelin, gamma-aminobutyric acid (GABA) 
      and L-glutamate signaling on gastric MMC by using suncus (Suncus murinus) as an 
      animal model, because of their similar gastric motor patterns to those observed 
      in humans and dogs. Intracerebroventricular (i.c.v.) administration of motilin 
      and ghrelin had no effect on phase I and II contractions, respectively. 
      Conversely, i.c.v. administration of GABA(A) receptor antagonist, during phase I 
      of the MMC, evoked phase II-like contractions and significantly increased the 
      motility index (MI). This was compared with the i.c.v. administration of GABA 
      which inhibited spontaneous phase II contractions with a significantly decreased 
      MI. In addition, i.c.v. administration of L-glutamate during phase I also induced 
      phase II-like irregular contractions with a significant increase in the MI. Taken 
      together with previous findings, these results suggest that central GABAergic and 
      glutamatergic signaling, with the coordination of both peripheral motilin and 
      ghrelin, regulate phase II contractions of MMC in the fasted state.
FAU - Horita, Taichi
AU  - Horita T
AD  - Area of Regulatory Biology, Division of Life Science, Graduate School of Science 
      and Engineering, Saitama University, 255 Shimo-ohkubo, Sakuraku, Saitama 
      338-8570, Japan.
FAU - Koyama, Kouhei
AU  - Koyama K
AD  - Area of Regulatory Biology, Division of Life Science, Graduate School of Science 
      and Engineering, Saitama University, 255 Shimo-ohkubo, Sakuraku, Saitama 
      338-8570, Japan.
FAU - Takemi, Shota
AU  - Takemi S
AD  - Area of Regulatory Biology, Division of Life Science, Graduate School of Science 
      and Engineering, Saitama University, 255 Shimo-ohkubo, Sakuraku, Saitama 
      338-8570, Japan.
FAU - Tanaka, Toru
AU  - Tanaka T
AD  - Faculty of Pharmaceutical Sciences, Department of Pharmaceutical and Health 
      Sciences, Josai University, 1-1 Keiyaki dai, Sakado, Saitama 350-0295, Japan.
FAU - Sakai, Takafumi
AU  - Sakai T
AD  - Area of Regulatory Biology, Division of Life Science, Graduate School of Science 
      and Engineering, Saitama University, 255 Shimo-ohkubo, Sakuraku, Saitama 
      338-8570, Japan.
AD  - Area of Life-NanoBio, Division of Strategy Research, Graduate School of Science 
      and Engineering, Saitama University, 255 Shimo-okubo, Sakura-ku, Saitama 
      338-8570, Japan.
FAU - Sakata, Ichiro
AU  - Sakata I
AD  - Area of Regulatory Biology, Division of Life Science, Graduate School of Science 
      and Engineering, Saitama University, 255 Shimo-ohkubo, Sakuraku, Saitama 
      338-8570, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - J Smooth Muscle Res
JT  - Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi
JID - 9211664
RN  - 0 (Ghrelin)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 52906-92-0 (Motilin)
SB  - IM
MH  - Animals
MH  - Brain/drug effects/*physiology
MH  - Fasting
MH  - GABAergic Neurons/drug effects/*physiology
MH  - Gastrointestinal Motility/drug effects
MH  - Ghrelin/pharmacology
MH  - Glutamic Acid/*metabolism
MH  - Male
MH  - Motilin/pharmacology
MH  - Muscle Contraction/drug effects/*physiology
MH  - Myoelectric Complex, Migrating/drug effects/*physiology
MH  - Neurons/drug effects/*physiology
MH  - Shrews
MH  - Stomach/drug effects/*physiology
PMC - PMC6380905
OTO - NOTNLM
OT  - GABA
OT  - Suncus murinus
OT  - ghrelin
OT  - glutamate
OT  - motilin
EDAT- 2019/02/23 06:00
MHDA- 2019/09/29 06:00
PMCR- 2018/01/01
CRDT- 2019/02/22 06:00
PHST- 2019/02/22 06:00 [entrez]
PHST- 2019/02/23 06:00 [pubmed]
PHST- 2019/09/29 06:00 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 0492 [pii]
AID - 10.1540/jsmr.54.91 [doi]
PST - ppublish
SO  - J Smooth Muscle Res. 2018;54(0):91-99. doi: 10.1540/jsmr.54.91.