PMID- 30787527
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 0974-620X (Print)
IS  - 0974-7842 (Electronic)
IS  - 0974-620X (Linking)
VI  - 12
IP  - 1
DP  - 2019 Jan-Apr
TI  - Ascorbic acid versus placebo in postoperative lid edema postphotorefractive 
      keratectomy: A double-masked, randomized, prospective study.
PG  - 4-9
LID - 10.4103/ojo.OJO_187_2017 [doi]
AB  - INTRODUCTION: Photorefractive keratectomy (PRK) is a proper type of refractive 
      surgery used to remodel corneal stroma to compensate refractive errors. Corneal 
      haze was reported as one of the side effects in several studies. This study was 
      conducted for investigation of the effect of preventive effect of Vitamin C on 
      eyelid edema, corneal haze, corneal epithelial healing, mitigation of pain, and 
      epiphora. MATERIALS AND METHODS: This study has been performed as a double-blind 
      clinical trial on 51 patients who underwent PRK surgery. The patients were 
      randomly divided into two groups as follows: case group who received oral 
      ascorbic acid 250 mg once daily for 7 days and control group that took placebo 3 
      days before and 4 days after the surgical operation. The patients underwent a 
      surgical operation on day 0. Then, the following factors were evaluated as the 
      main outcome: postoperative lid edema, pain, corneal haze, and corneal 
      reepithelialization. RESULTS: The mean age of the patients was 28.52 +/- 8.05 
      years. There was no statistically significant difference in the primary outcome 
      of the subjective pain scores along with corneal haze and corneal 
      reepithelialization between the treatment and placebo groups at any point during 
      the postoperative period; however, there was a statistically significant 
      difference and trend for lower lid edema in the ascorbic acids group on 
      postoperative day 1 (P < 0.05). CONCLUSION: This study demonstrates that ascorbic 
      acid may provide an alternative or add-on option for lid edema relief after PRK.
FAU - Alishiri, Aliagha
AU  - Alishiri A
AD  - Department of Ophthalmology, Hormozgan University of Medical Sciences, Bandar 
      Abbas, Iran.
FAU - Mosavi, Seyed Aliasghar
AU  - Mosavi SA
AD  - Bina Eye Hospital Research Center, Tehran, Iran.
AD  - Vision Health Research Center, Semnan University of Medical Sciences, Semnan, 
      Iran.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Oman J Ophthalmol
JT  - Oman journal of ophthalmology
JID - 101519430
PMC - PMC6380147
OTO - NOTNLM
OT  - Ascorbic acid
OT  - Vitamin C
OT  - ocular side effects
OT  - photorefractive keratectomy
COIS- There are no conflicts of interest.
EDAT- 2019/02/23 06:00
MHDA- 2019/02/23 06:01
PMCR- 2019/01/01
CRDT- 2019/02/22 06:00
PHST- 2019/02/22 06:00 [entrez]
PHST- 2019/02/23 06:00 [pubmed]
PHST- 2019/02/23 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - OJO-12-4 [pii]
AID - 10.4103/ojo.OJO_187_2017 [doi]
PST - ppublish
SO  - Oman J Ophthalmol. 2019 Jan-Apr;12(1):4-9. doi: 10.4103/ojo.OJO_187_2017.