PMID- 30787633
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220331
IS  - 1178-7090 (Print)
IS  - 1178-7090 (Electronic)
IS  - 1178-7090 (Linking)
VI  - 12
DP  - 2019
TI  - Melatonin is a biomarker of circadian dysregulation and is correlated with major 
      depression and fibromyalgia symptom severity.
PG  - 545-556
LID - 10.2147/JPR.S176857 [doi]
AB  - OBJECTIVE: This study compared urinary 6-sulfatoxymelatonin (aMT6s) over 24 hours 
      among fibromyalgia (FM), major depression disorder (MDD), and healthy control 
      (HC) groups, and examined whether rhythm is correlated with depressive symptoms. 
      To answer this question we compared the rhythm of urinary aMT6s secretion among 
      each group in four time series: morning (06:00-12:00 hours), afternoon 
      (12:00-18:00 hours), evening (18:00-24:00 hours), and night (24:00-06:00 hours). 
      In the FM subjects, we assessed if the rhythm of urinary aMT6s secretion is 
      associated with pain severity, sleep quality, number of trigger points (NTPs), 
      and the pain pressure threshold (PPT). PATIENTS AND METHODS: We included 54 
      women, aged 18-60 years with diagnosis of FM (n=18), MDD (n=19), and HC (n =17). 
      The 24-hour urinary aMT6s was evaluated according to four standardized periods. 
      The assessment instruments were the Hamilton Depression Rating Scale (HDRS), 
      Pittsburgh Sleep Quality Index, and Fibromyalgia Impact Questionnaire. RESULTS: A 
      generalized estimating equation revealed no difference in the daily load of aMT6s 
      secretion among the three groups (P=0.49). However, at the daily time 
      (06:00-18:00 hours), the load secretion of aMT6s reached 41.54% and 60.71% in the 
      FM and MDD, respectively, as compared to 20.73% in the HC (P<0.05). A higher 
      score in the HDRS was positively correlated with the amount of aMT6s secretion 
      during daytime (06:00-18:00 hours). Also, multivariate linear regression revealed 
      that in FM subjects, the aMT6s secretion during daytime (06:00-18:00 hours) was 
      negatively correlated with the PPTlog (partial eta2=0.531, P=0.001). However, it 
      was positively correlated with depressive symptoms (partial eta2=0.317, P=0.01); 
      PQSI (partial eta2=0.306, P=0.017), and NTPs (partial eta2=0.23, P=0.04). CONCLUSION: 
      A more significant load of aMT6s secretion during daytime hours was observed in 
      MDD and FM subjects compared to HC. These findings help to comprehend the 
      biological basis of these disorders and show how disruption in melatonin 
      secretion is positively correlated with clinical symptoms.
FAU - Caumo, Wolnei
AU  - Caumo W
AD  - School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto 
      Alegre, Brazil, wcaumo@hcpa.edu.br.
AD  - Pain and Palliative Care Service at Hospital de Clinicas de Porto Alegre (HCPA), 
      Laboratory of Pain and Neuromodulation at UFRGS, Porto Alegre, Brazil, 
      wcaumo@hcpa.edu.br.
AD  - Pain and Anesthesia in Surgery Department, School of Medicine, UFRGS, Porto 
      Alegre, Brazil, wcaumo@hcpa.edu.br.
FAU - Hidalgo, Maria Paz
AU  - Hidalgo MP
AD  - Psychiatry Department, School of Medicine, UFRGS, Porto Alegre, Brazil.
AD  - Laboratorio de Cronobiologia e Sono do Hospital de Clinicas de Porto Alegre; 
      Porto Alegre, Brazil.
FAU - Souza, Andressa
AU  - Souza A
AD  - Postgraduate Program in Health and Human Development, La Salle Universitary 
      Center, Canoas, Brazil.
FAU - Torres, Iraci L S
AU  - Torres ILS
AD  - School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto 
      Alegre, Brazil, wcaumo@hcpa.edu.br.
AD  - Pharmacology Department, Instituto de Ciencias Basicas da Saude, UFRGS, Porto 
      Alegre, Brazil.
FAU - Antunes, Luciana C
AU  - Antunes LC
AD  - Centro de Ciencias da Saude - Departamento de Nutricao da Universidade Federal De 
      Santa Catarina, Florianopolis, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20190131
PL  - New Zealand
TA  - J Pain Res
JT  - Journal of pain research
JID - 101540514
PMC - PMC6365222
OTO - NOTNLM
OT  - 6 sulfatoxymelatonin (aMT6s)
OT  - depression
OT  - fibromyalgia
OT  - melatonin
OT  - pain
COIS- Disclosure The authors report no conflicts of interest in this work.
EDAT- 2019/02/23 06:00
MHDA- 2019/02/23 06:01
PMCR- 2019/01/31
CRDT- 2019/02/22 06:00
PHST- 2019/02/22 06:00 [entrez]
PHST- 2019/02/23 06:00 [pubmed]
PHST- 2019/02/23 06:01 [medline]
PHST- 2019/01/31 00:00 [pmc-release]
AID - jpr-12-545 [pii]
AID - 10.2147/JPR.S176857 [doi]
PST - epublish
SO  - J Pain Res. 2019 Jan 31;12:545-556. doi: 10.2147/JPR.S176857. eCollection 2019.