PMID- 30787986
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1943-8141 (Print)
IS  - 1943-8141 (Electronic)
IS  - 1943-8141 (Linking)
VI  - 11
IP  - 1
DP  - 2019
TI  - Efficacy of subcutaneous immunotherapy in a mouse model of Humulus pollen-induced 
      allergic asthma.
PG  - 280-289
AB  - OBJECTIVE: The aim of this study was to evaluate the therapeutic effect of 
      subcutaneous injection of high-dose of Humulus pollen allergen on a mouse model 
      of allergic asthma. METHOD: Humulus pollen-sensitized mice received either 
      regular subcutaneous injections of Humulus pollen allergen extract or control 
      treatment were sacrificed. Airway responsiveness, pulmonary inflammatory cell 
      infiltration, serum cytokine secretion and serum immunoglobulin E (IgE) and G2a 
      (IgG2a) levels were measured. RESULT: Our results showed that subcutaneous 
      immunotherapy with high-dose of Humulus pollen allergen could obviously relieve 
      the symptoms and improve the pulmonary function in mice with allergic asthma. It 
      also elevated serum IgE and IgG level compared with model group. The Humulus 
      pollen allergens could be identified in serum and the molecular weight of serum 
      proteins that had the maximum binding to allergen were ~25 kDa and ~38 kDa in 7 
      cases (70%) and 6 cases (60%), respectively. CONCLUSION: Subcutaneous 
      immunotherapy (high-dose) could effectively alleviate airway hyperresponsiveness 
      and reduce airway inflammatory infiltration in allergic asthmatic mice.
FAU - Kong, Rui
AU  - Kong R
AD  - Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of 
      Medical Sciences and Peking Union Medical College Beijing, China.
FAU - Yin, Jia
AU  - Yin J
AD  - Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of 
      Medical Sciences and Peking Union Medical College Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20190115
PL  - United States
TA  - Am J Transl Res
JT  - American journal of translational research
JID - 101493030
PMC - PMC6357336
OTO - NOTNLM
OT  - Immunotherapy
OT  - allergic asthma
OT  - humulus pollen
OT  - immunoglobulin
COIS- None.
EDAT- 2019/02/23 06:00
MHDA- 2019/02/23 06:01
PMCR- 2019/01/15
CRDT- 2019/02/22 06:00
PHST- 2018/06/28 00:00 [received]
PHST- 2018/12/09 00:00 [accepted]
PHST- 2019/02/22 06:00 [entrez]
PHST- 2019/02/23 06:00 [pubmed]
PHST- 2019/02/23 06:01 [medline]
PHST- 2019/01/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Transl Res. 2019 Jan 15;11(1):280-289. eCollection 2019.