PMID- 30789017
OWN - NLM
STAT- MEDLINE
DCOM- 20200804
LR  - 20200804
IS  - 1479-9731 (Electronic)
IS  - 1479-9723 (Print)
IS  - 1479-9723 (Linking)
VI  - 16
DP  - 2019 Jan-Dec
TI  - Physical activity in COPD: Minimal clinically important difference for medical 
      events.
PG  - 1479973118816424
LID - 10.1177/1479973118816424 [doi]
LID - 1479973118816424
AB  - Estimates of the minimal clinically important difference (MCID) for physical 
      activity (PA) in chronic obstructive pulmonary disease (COPD) are needed. The 
      objective is to provide an anchor-based estimate of the MCID for daily step 
      count. PA was promoted in persons with COPD using a pedometer (Omron HJ-720ITC) 
      alone or a pedometer plus interactive website for 3 months. Participants wore the 
      pedometer daily and received phone calls monthly to ascertain medical events. 
      Medical events were counted when a participant self-reported that he/she had (1) 
      worsening of breathing, (2) change to breathing medications, (3) medical care 
      from an emergency room for any reason, or (4) hospitalization for any reason. 
      Generalized linear regression models assessed daily step count as change at the 
      end of study and averaged over the 15, 31, or 61 days centered on the event, in 
      those with an event compared to those without one. All categories of events 
      carried equal weight in the analyses. We studied 93 persons, 46 of whom had an 
      event. Participants who experienced an event had a decrease of 1086 (95% 
      confidence interval (CI): -2124 to -48) or 887 (95% CI: -2030 to 257) steps/day 
      in the pedometer plus website or pedometer alone groups, respectively, compared 
      to those without one. In the days centered on an event, participants who had an 
      event experienced a decrease of 882-983 steps/day (pedometer plus website) or a 
      decrease of 351-495 steps/day (pedometer alone), compared to those without one. 
      The MCID for PA in COPD ranges from 350 steps/day to 1100 steps/day.
FAU - Teylan, Merilee
AU  - Teylan M
AD  - 1 Pulmonary and Critical Care Medicine Section, VA Boston Healthcare System, 
      Boston, MA, USA.
FAU - Kantorowski, Ana
AU  - Kantorowski A
AD  - 1 Pulmonary and Critical Care Medicine Section, VA Boston Healthcare System, 
      Boston, MA, USA.
FAU - Homsy, Diana
AU  - Homsy D
AD  - 1 Pulmonary and Critical Care Medicine Section, VA Boston Healthcare System, 
      Boston, MA, USA.
FAU - Kadri, Reema
AU  - Kadri R
AD  - 2 Department of Family Medicine, University of Michigan, Ann Arbor, MI, USA.
FAU - Richardson, Caroline
AU  - Richardson C
AD  - 2 Department of Family Medicine, University of Michigan, Ann Arbor, MI, USA.
FAU - Moy, Marilyn
AU  - Moy M
AUID- ORCID: 0000-0002-2471-9218
AD  - 1 Pulmonary and Critical Care Medicine Section, VA Boston Healthcare System, 
      Boston, MA, USA.
AD  - 3 Harvard Medical School, Boston, MA, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Chron Respir Dis
JT  - Chronic respiratory disease
JID - 101197408
SB  - IM
MH  - Accelerometry
MH  - Aged
MH  - Aged, 80 and over
MH  - Disease Progression
MH  - Emergency Service, Hospital/statistics & numerical data
MH  - *Exercise
MH  - Female
MH  - Hospitalization/statistics & numerical data
MH  - Humans
MH  - Internet-Based Intervention
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - *Minimal Clinically Important Difference
MH  - Pulmonary Disease, Chronic Obstructive/*rehabilitation
MH  - Randomized Controlled Trials as Topic
MH  - Symptom Flare Up
MH  - *Walking
PMC - PMC6302974
OTO - NOTNLM
OT  - Anchor-based method
OT  - COPD
OT  - daily step count
OT  - exercise
OT  - physical activity
COIS- Declaration of conflicting interests: The author(s) declared the following 
      potential conflicts of interest with respect to the research, authorship, and/or 
      publication of this article: Dr. Moy reports receiving an honorarium for 
      consulting from AstraZeneca, outside the submitted work.
EDAT- 2019/02/23 06:00
MHDA- 2020/08/05 06:00
PMCR- 2018/12/18
CRDT- 2019/02/22 06:00
PHST- 2019/02/22 06:00 [entrez]
PHST- 2019/02/23 06:00 [pubmed]
PHST- 2020/08/05 06:00 [medline]
PHST- 2018/12/18 00:00 [pmc-release]
AID - 10.1177_1479973118816424 [pii]
AID - 10.1177/1479973118816424 [doi]
PST - ppublish
SO  - Chron Respir Dis. 2019 Jan-Dec;16:1479973118816424. doi: 
      10.1177/1479973118816424.