PMID- 30789024
OWN - NLM
STAT- MEDLINE
DCOM- 20200828
LR  - 20231005
IS  - 1479-9731 (Electronic)
IS  - 1479-9723 (Print)
IS  - 1479-9723 (Linking)
VI  - 16
DP  - 2019 Jan-Dec
TI  - Unravelling the mystery of the 'minimum important difference' using practical 
      outcome measures in chronic respiratory disease.
PG  - 1479973118816491
LID - 10.1177/1479973118816491 [doi]
LID - 1479973118816491
AB  - It is important for clinicians and researchers to understand the effects of 
      treatments on their patients, both at an individual and group level. In clinical 
      studies, treatment effects are often reported as a change in the outcome measure 
      supported by a measure of variability; for example, the mean change with 95% 
      confidence intervals and a probability ( p) value to indicate the level of 
      statistical significance. However, a statistically significant change may not 
      indicate a clinically meaningful or important change for clinicians or patients 
      to interpret. The minimum clinically important difference (MCID) or minimally 
      important difference (MID) has therefore been developed to add clinical relevance 
      or patient experience to the reporting of an outcome measure. In this article, we 
      consider the concept of the MID using the example of practical outcome measures 
      in patients with CRD. We describe the various ways in which an MID can be 
      calculated via anchor- and distribution-based methods, looking at practical 
      examples and considering the importance of understanding how an MID was derived 
      when seeking to apply it to a particular situation. The terms MID and MCID are 
      challenging and often used interchangeably. However, we propose all MIDs are 
      described as such, but they could be qualified by a suffix: MIDS (MID - 
      Statistical), MID-C (MID - Clinical outcome), MID-P (MID - Patient determined). 
      However, this type of classification would only work if accepted and adopted. In 
      the meantime, we advise clinicians and researchers to use an MID where possible 
      to aid their interpretation of functional outcome measures and effects of 
      interventions, to add meaning above statistical significance alone.
FAU - Houchen-Wolloff, Linzy
AU  - Houchen-Wolloff L
AUID- ORCID: 0000-0003-4940-8835
AD  - 1 Centre for Exercise and Rehabilitation Science (CERS), NIHR Leicester 
      Biomedical Research Centre - Respiratory, Glenfield Hospital, Leicester, UK.
AD  - 2 Department of Respiratory Science, University of Leicester, Leicester, UK.
AD  - 3 Therapy Department, University Hospitals of Leicester NHS Trust, Leicester, UK.
FAU - Evans, Rachael A
AU  - Evans RA
AD  - 1 Centre for Exercise and Rehabilitation Science (CERS), NIHR Leicester 
      Biomedical Research Centre - Respiratory, Glenfield Hospital, Leicester, UK.
AD  - 2 Department of Respiratory Science, University of Leicester, Leicester, UK.
AD  - 4 Department of Respiratory Medicine, Thoracic Surgery and Allergy, University 
      Hospitals of Leicester NHS Trust, Leicester, UK.
LA  - eng
GR  - CS-2016-16-020/DH_/Department of Health/United Kingdom
PT  - Journal Article
PL  - England
TA  - Chron Respir Dis
JT  - Chronic respiratory disease
JID - 101197408
SB  - IM
MH  - Analysis of Variance
MH  - Chronic Disease
MH  - *Diagnostic Self Evaluation
MH  - Humans
MH  - *Minimal Clinically Important Difference
MH  - Outcome Assessment, Health Care/methods
MH  - *Patient-Centered Care/methods/standards/statistics & numerical data
MH  - Physical Functional Performance
MH  - Recovery of Function/physiology
MH  - *Respiratory Tract Diseases/diagnosis/physiopathology/therapy
MH  - *Treatment Outcome
MH  - United Kingdom
PMC - PMC6323555
OTO - NOTNLM
OT  - Exercise
OT  - MCID
OT  - MID
OT  - lung disease
OT  - outcome assessment
OT  - physical function
OT  - respiratory disease
COIS- Declaration of conflicting interest: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2019/02/23 06:00
MHDA- 2020/08/29 06:00
PMCR- 2019/01/03
CRDT- 2019/02/22 06:00
PHST- 2019/02/22 06:00 [entrez]
PHST- 2019/02/23 06:00 [pubmed]
PHST- 2020/08/29 06:00 [medline]
PHST- 2019/01/03 00:00 [pmc-release]
AID - 10.1177_1479973118816491 [pii]
AID - 10.1177/1479973118816491 [doi]
PST - ppublish
SO  - Chron Respir Dis. 2019 Jan-Dec;16:1479973118816491. doi: 
      10.1177/1479973118816491.