PMID- 30789304
OWN - NLM
STAT- MEDLINE
DCOM- 20200529
LR  - 20200529
IS  - 1557-8518 (Electronic)
IS  - 1540-4196 (Linking)
VI  - 17
IP  - 3
DP  - 2019 Apr
TI  - Benefits of 1-Year Lifestyle Modification Program on Exercise Capacity and 
      Diastolic Function Among Coronary Artery Disease Men With and Without Type 2 
      Diabetes.
PG  - 149-159
LID - 10.1089/met.2018.0092 [doi]
AB  - BACKGROUND: To assess the benefits of a 1-year lifestyle modification program on 
      exercise capacity and diastolic function in men with left ventricular (LV) 
      diastolic dysfunction (LVDD) and coronary artery disease (CAD), according to 
      glucose tolerance status. METHODS: Fifty-three men (62 +/- 8 years; BMI: 
      27.3 +/- 3.5 kg/m(2)) with LVDD and CAD were enrolled in a 1-year lifestyle 
      modification program based on dietary management and increased physical activity. 
      Patients were classified by using a 75 grams oral glucose tolerance test as 
      having normal glucose tolerance (n = 16), prediabetes (n = 23), or type 2 
      diabetes mellitus (T2DM) (n = 14). Cardiac morphology and function, visceral fat, 
      and cardiac fat depots were measured using magnetic resonance imaging, whereas 
      exercise capacity [cardiorespiratory fitness (CRF)] (VO(2peak)) was assessed with 
      a maximal treadmill test. RESULTS: The 1-year lifestyle modification program was 
      associated with reductions in body weight, and visceral and cardiac fat levels 
      (all P < 0.05). CRF increased by 13% (24.9 +/- 4.1 vs. 28.2 +/- 4.8 mL O(2)/kg/min, 
      P < 0.0001). Moreover, half of patients (53%) improved LV diastolic function in 
      response to the lifestyle intervention. Multiple regression analyses revealed 
      that age (partial R(2) = 26.9, P < 0.0001) and presence of T2DM (partial 
      R(2) = 5.9, P = 0.04) were the stronger predictors of change in diastolic 
      function, while favorable change in LV remodeling index was the best predictor of 
      improvement in LV diastolic function after the lifestyle intervention 
      (R(2) = 21.9, P = 0.002). CONCLUSIONS: Irrespective of glucose tolerance status, 
      a 1-year lifestyle modification program in men with LVDD and CAD is associated 
      with significant improvements in exercise capacity and LV diastolic function in 
      more than half of patients.
FAU - Piche, Marie-Eve
AU  - Piche ME
AD  - 1 Department of Cardiology, Quebec Heart and Lung Institute, Quebec, Canada.
AD  - 2 Faculty of Medicine and Laval University, Quebec, Canada.
FAU - Poirier, Paul
AU  - Poirier P
AD  - 1 Department of Cardiology, Quebec Heart and Lung Institute, Quebec, Canada.
AD  - 3 Faculty of Pharmacy, Laval University, Quebec, Canada.
FAU - Marette, Andre
AU  - Marette A
AD  - 1 Department of Cardiology, Quebec Heart and Lung Institute, Quebec, Canada.
FAU - Mathieu, Patrick
AU  - Mathieu P
AD  - 1 Department of Cardiology, Quebec Heart and Lung Institute, Quebec, Canada.
AD  - 2 Faculty of Medicine and Laval University, Quebec, Canada.
FAU - Levesque, Valerie
AU  - Levesque V
AD  - 1 Department of Cardiology, Quebec Heart and Lung Institute, Quebec, Canada.
FAU - Bibeau, Karine
AU  - Bibeau K
AD  - 1 Department of Cardiology, Quebec Heart and Lung Institute, Quebec, Canada.
FAU - Larose, Eric
AU  - Larose E
AD  - 1 Department of Cardiology, Quebec Heart and Lung Institute, Quebec, Canada.
AD  - 2 Faculty of Medicine and Laval University, Quebec, Canada.
FAU - Despres, Jean-Pierre
AU  - Despres JP
AD  - 1 Department of Cardiology, Quebec Heart and Lung Institute, Quebec, Canada.
AD  - 2 Faculty of Medicine and Laval University, Quebec, Canada.
LA  - eng
GR  - CIHR/Canada
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190221
PL  - United States
TA  - Metab Syndr Relat Disord
JT  - Metabolic syndrome and related disorders
JID - 101150318
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiorespiratory Fitness
MH  - Combined Modality Therapy
MH  - Coronary Artery Disease/complications/physiopathology/*therapy
MH  - Diabetes Mellitus, Type 2/complications/physiopathology/*therapy
MH  - Diastole/physiology
MH  - *Diet Therapy/methods
MH  - Exercise/physiology
MH  - Exercise Test
MH  - *Exercise Therapy/methods
MH  - Exercise Tolerance/*physiology
MH  - Humans
MH  - *Life Style
MH  - Male
MH  - Middle Aged
MH  - Risk Assessment
MH  - Risk Reduction Behavior
MH  - Ventricular Function, Left/*physiology
OTO - NOTNLM
OT  - cardiac fat depot
OT  - coronary artery disease
OT  - diastolic function
OT  - exercise capacity
OT  - lifestyle modification program
OT  - type 2 diabetes mellitus
EDAT- 2019/02/23 06:00
MHDA- 2020/05/30 06:00
CRDT- 2019/02/22 06:00
PHST- 2019/02/23 06:00 [pubmed]
PHST- 2020/05/30 06:00 [medline]
PHST- 2019/02/22 06:00 [entrez]
AID - 10.1089/met.2018.0092 [doi]
PST - ppublish
SO  - Metab Syndr Relat Disord. 2019 Apr;17(3):149-159. doi: 10.1089/met.2018.0092. 
      Epub 2019 Feb 21.