PMID- 30789512
OWN - NLM
STAT- MEDLINE
DCOM- 20191023
LR  - 20191023
IS  - 1524-4725 (Electronic)
IS  - 1076-0512 (Linking)
VI  - 45
IP  - 7
DP  - 2019 Jul
TI  - Lip and Perioral Enhancement With Hyaluronic Acid Dermal Fillers in Individuals 
      With Skin of Color.
PG  - 959-967
LID - 10.1097/DSS.0000000000001842 [doi]
AB  - BACKGROUND: Individuals with skin of color are underrepresented in studies of lip 
      and perioral enhancement. OBJECTIVE: To examine the effectiveness and safety of 
      hyaluronic acid (HA) dermal filler treatment for lip and perioral enhancement in 
      subjects with skin of color. METHODS: Data were pooled from subjects with 
      Fitzpatrick skin phototypes IV, V, or VI in 2 pivotal studies of HA dermal 
      fillers. Photonumeric scales were used to assess lip fullness (5-point scale) and 
      perioral lines and oral commissures severity (each 4-point scales). Safety was 
      assessed by injection site responses recorded in patient diaries and adverse 
      events (AEs). RESULTS: The cohort comprised 72 subjects (median age: 49.5 years; 
      95.8% female). Mean lip fullness improved from baseline by 1.1 points at 3 months 
      after treatment; 85.0% of subjects were responders (>/=1-point improvement). Of 
      subjects treated for perioral lines (n = 12) and oral commissures (n = 56), 90.9% 
      and 46.4%, respectively, were responders. Injection site responses were generally 
      mild or moderate in severity, resolved within 2 weeks, and were consistent with 
      those expected for HA dermal filler treatment. The most common AEs were injection 
      site mass (19.4%) and bruising (12.5%). CONCLUSION: Lip and perioral enhancement 
      with HA dermal fillers is effective and safe in subjects with skin of color.
FAU - Taylor, Susan C
AU  - Taylor SC
AD  - Department of Dermatology, Hospital of the University of Pennsylvania, 
      Philadelphia, Pennsylvania.
FAU - Downie, Jeanine B
AU  - Downie JB
AD  - Image Dermatology, Montclair, New Jersey.
FAU - Shamban, Ava
AU  - Shamban A
AD  - AVA MD, Santa Monica, California.
FAU - Few, Julius
AU  - Few J
AD  - The Few Institute for Aesthetic Plastic Surgery, Chicago, Illinois.
FAU - Weichman, Barry M
AU  - Weichman BM
AD  - Peloton Advantage, Parsippany, New Jersey.
FAU - Schumacher, Andrew
AU  - Schumacher A
AD  - Allergan plc, Irvine, California.
FAU - Gallagher, Conor J
AU  - Gallagher CJ
AD  - Allergan plc, Irvine, California.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - United States
TA  - Dermatol Surg
JT  - Dermatologic surgery : official publication for American Society for Dermatologic 
      Surgery [et al.]
JID - 9504371
RN  - 0 (Dermal Fillers)
RN  - 0 (Viscosupplements)
RN  - 9004-61-9 (Hyaluronic Acid)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Cosmetic Techniques
MH  - Dermal Fillers/*therapeutic use
MH  - *Face
MH  - Female
MH  - Humans
MH  - Hyaluronic Acid/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Rejuvenation
MH  - *Skin Pigmentation
MH  - Viscosupplements/*therapeutic use
MH  - Young Adult
EDAT- 2019/02/23 06:00
MHDA- 2019/10/24 06:00
CRDT- 2019/02/22 06:00
PHST- 2019/02/23 06:00 [pubmed]
PHST- 2019/10/24 06:00 [medline]
PHST- 2019/02/22 06:00 [entrez]
AID - 10.1097/DSS.0000000000001842 [doi]
PST - ppublish
SO  - Dermatol Surg. 2019 Jul;45(7):959-967. doi: 10.1097/DSS.0000000000001842.