PMID- 30790116 OWN - NLM STAT- MEDLINE DCOM- 20190722 LR - 20200225 IS - 1875-8312 (Electronic) IS - 1569-5794 (Linking) VI - 35 IP - 7 DP - 2019 Jul TI - Left atrial fibrosis correlates with extent of left ventricular myocardial delayed enhancement and left ventricular strain in hypertrophic cardiomyopathy. PG - 1309-1318 LID - 10.1007/s10554-019-01551-7 [doi] AB - Hypertrophic cardiomyopathy (HCM) is associated with increased left ventricular (LV) mass, decreased myocardial strain, and the presence of LV fibrosis and scar. The relationship between LV scar and fibrosis with left atrial (LA) fibrosis in the setting of HCM has not been examined. The purpose of this study is to demonstrate a correlation between the degree of LA fibrosis and LV parameters in subjects with HCM. Twenty-eight subjects with HCM were imaged on a 1.5T MRI scanner with cine, LV and LA late gadolinium enhancement (LGE) sequences. LA LGE and LA measurements were correlated with LV measurements of volumes, mass, strain, and LGE. Other clinical conditions and medication usage were also examined and evaluated for correlation with LA and LV parameters. LV LGE was identified in 24 (86%) of the cases and LA LGE was identified in all of the cases. Extent of LA fibrosis significantly correlated with percent LV LGE (r = 0.64, p = 0.001), but not with indexed LV mass or maximum wall thickness. Extent of LA fibrosis also moderately correlated with decreased LV global strain (radial, r = - 0.50, p = 0.013; circumferential, r = 0.47, p = 0.02; longitudinal, r = 0.52, p = 0.013). Increased LA systolic volume correlated moderately with LV end diastolic volume (r = 0.50, p = 0.006). Patients on therapy with Renin-Angiotensin-Aldosterone System (RAAS) Inhibition had significantly less LA LGE compared to those without (18.6% vs 10.8%, p = 0.023). LA fibrosis, as measured by LGE, is prevalent in HCM and is correlated with LV LGE. The correlation between LA and LV LGE might suggest either that LA fibrosis is a consequence of LV remodeling, or that LA and LV fibrosis are both manifestations of the same cardiomyopathic process. Further study is warranted to determine the causality of LA scar in this population. FAU - Latif, Syed R AU - Latif SR AD - Department of Internal Medicine (Cardiology), Yale School of Medicine, 330 Cedar St, Boardman 110, P.O. Box 208056, New Haven, CT, 06520-8056, USA. FAU - Nguyen, Vinh Q AU - Nguyen VQ AUID- ORCID: 0000-0001-7989-4294 AD - Department of Internal Medicine (Cardiology), Yale School of Medicine, 330 Cedar St, Boardman 110, P.O. Box 208056, New Haven, CT, 06520-8056, USA. AD - Department of Cardiovascular Medicine, Allegheny General Hospital, 320 E North Ave, CVI 3, Pittsburgh, PA, 15212, USA. FAU - Peters, Dana C AU - Peters DC AD - Department of Internal Medicine (Cardiology), Yale School of Medicine, 330 Cedar St, Boardman 110, P.O. Box 208056, New Haven, CT, 06520-8056, USA. AD - Department of Radiology and Biomedical Imaging, Yale School of Medicine, PO Box 208042, New Haven, CT, 06520-8042, USA. FAU - Soufer, Aaron AU - Soufer A AD - Department of Internal Medicine (Cardiology), Yale School of Medicine, 330 Cedar St, Boardman 110, P.O. Box 208056, New Haven, CT, 06520-8056, USA. FAU - Henry, Mariana L AU - Henry ML AD - Department of Internal Medicine (Cardiology), Yale School of Medicine, 330 Cedar St, Boardman 110, P.O. Box 208056, New Haven, CT, 06520-8056, USA. FAU - Grunseich, Karl AU - Grunseich K AD - Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue, M-391, San Francisco, CA, 94143-0628, USA. FAU - Testani, Jeffrey AU - Testani J AD - Department of Internal Medicine (Cardiology), Yale School of Medicine, 330 Cedar St, Boardman 110, P.O. Box 208056, New Haven, CT, 06520-8056, USA. FAU - Hur, David J AU - Hur DJ AD - Department of Internal Medicine (Cardiology), Yale School of Medicine, 330 Cedar St, Boardman 110, P.O. Box 208056, New Haven, CT, 06520-8056, USA. FAU - Huber, Steffen AU - Huber S AD - Department of Radiology and Biomedical Imaging, Yale School of Medicine, PO Box 208042, New Haven, CT, 06520-8042, USA. FAU - Mojibian, Hamid AU - Mojibian H AD - Department of Radiology and Biomedical Imaging, Yale School of Medicine, PO Box 208042, New Haven, CT, 06520-8042, USA. FAU - Dicks, Demetrius AU - Dicks D AD - Department of Radiology and Biomedical Imaging, Yale School of Medicine, PO Box 208042, New Haven, CT, 06520-8042, USA. FAU - Sinusas, Albert J AU - Sinusas AJ AD - Department of Internal Medicine (Cardiology), Yale School of Medicine, 330 Cedar St, Boardman 110, P.O. Box 208056, New Haven, CT, 06520-8056, USA. AD - Department of Radiology and Biomedical Imaging, Yale School of Medicine, PO Box 208042, New Haven, CT, 06520-8042, USA. FAU - Meadows, Judith L AU - Meadows JL AD - Department of Internal Medicine (Cardiology), Yale School of Medicine, 330 Cedar St, Boardman 110, P.O. Box 208056, New Haven, CT, 06520-8056, USA. FAU - Papoutsidakis, Nikolaos AU - Papoutsidakis N AD - Department of Internal Medicine (Cardiology), Yale School of Medicine, 330 Cedar St, Boardman 110, P.O. Box 208056, New Haven, CT, 06520-8056, USA. FAU - Jacoby, Daniel AU - Jacoby D AD - Department of Internal Medicine (Cardiology), Yale School of Medicine, 330 Cedar St, Boardman 110, P.O. Box 208056, New Haven, CT, 06520-8056, USA. FAU - Baldassarre, Lauren A AU - Baldassarre LA AUID- ORCID: 0000-0003-4173-3449 AD - Department of Internal Medicine (Cardiology), Yale School of Medicine, 330 Cedar St, Boardman 110, P.O. Box 208056, New Haven, CT, 06520-8056, USA. lauren.baldassarre@yale.edu. AD - Department of Radiology and Biomedical Imaging, Yale School of Medicine, PO Box 208042, New Haven, CT, 06520-8042, USA. lauren.baldassarre@yale.edu. AD - , New Haven, CT, USA. lauren.baldassarre@yale.edu. LA - eng PT - Journal Article DEP - 20190221 PL - United States TA - Int J Cardiovasc Imaging JT - The international journal of cardiovascular imaging JID - 100969716 RN - 0 (Angiotensin Receptor Antagonists) RN - 0 (Angiotensin-Converting Enzyme Inhibitors) RN - 0 (Contrast Media) RN - 0 (Organometallic Compounds) RN - 1BJ477IO2L (gadobutrol) SB - IM MH - Adult MH - Aged MH - Angiotensin Receptor Antagonists/therapeutic use MH - Angiotensin-Converting Enzyme Inhibitors/therapeutic use MH - *Atrial Function, Left/drug effects MH - *Atrial Remodeling/drug effects MH - Cardiomyopathy, Hypertrophic/*diagnostic imaging/drug therapy/pathology/physiopathology MH - Contrast Media/administration & dosage MH - Female MH - Fibrosis MH - Heart Atria/*diagnostic imaging/drug effects/pathology/physiopathology MH - Heart Ventricles/*diagnostic imaging/drug effects/pathology/physiopathology MH - Humans MH - Hypertrophy, Left Ventricular/*diagnostic imaging/drug therapy/pathology/physiopathology MH - *Magnetic Resonance Imaging, Cine MH - Male MH - Middle Aged MH - Organometallic Compounds/administration & dosage MH - Predictive Value of Tests MH - Retrospective Studies MH - Ventricular Dysfunction, Left/*diagnostic imaging/drug therapy/pathology/physiopathology MH - *Ventricular Function, Left/drug effects MH - *Ventricular Remodeling/drug effects OTO - NOTNLM OT - Hypertrophic cardiomyopathy OT - Left atrial fibrosis OT - Left ventricular late gadolinium enhancement OT - Left ventricular strain EDAT- 2019/02/23 06:00 MHDA- 2019/07/23 06:00 CRDT- 2019/02/22 06:00 PHST- 2018/07/06 00:00 [received] PHST- 2019/02/02 00:00 [accepted] PHST- 2019/02/23 06:00 [pubmed] PHST- 2019/07/23 06:00 [medline] PHST- 2019/02/22 06:00 [entrez] AID - 10.1007/s10554-019-01551-7 [pii] AID - 10.1007/s10554-019-01551-7 [doi] PST - ppublish SO - Int J Cardiovasc Imaging. 2019 Jul;35(7):1309-1318. doi: 10.1007/s10554-019-01551-7. Epub 2019 Feb 21.