PMID- 30790120
OWN - NLM
STAT- MEDLINE
DCOM- 20200407
LR  - 20200408
IS  - 1559-0720 (Electronic)
IS  - 0163-4984 (Linking)
VI  - 192
IP  - 2
DP  - 2019 Dec
TI  - Association of Serum Zinc and Vitamin A Levels with Severity of Retinopathy in 
      Type 2 Diabetic Patients: a Cross-Sectional Study.
PG  - 123-128
LID - 10.1007/s12011-019-01664-z [doi]
AB  - Diabetic retinopathy (DR) is a common microvascular disorder which occurs in type 
      2 diabetes mellitus (T2DM) patients due to chronic hyperglycemia. Previous 
      studies reported that serum zinc (Zn) and vitamin A levels were associated with 
      certain diabetic microvascular complications. However, the relationship between 
      Zn and vitamin A levels with the severity of DR in type 2 diabetic patients is 
      not clear. We aimed to analyze the relationship between serum Zn and vitamin A 
      levels with the severity of DR in T2DM. Sixty T2DM patients were selected from 
      whom attending to the ophthalmology center of hospital from June 2017 and Feb 
      2018. Patients were categorized as controls, non-proliferative DR (NPDR), and 
      proliferative DR (PDR). Anthropometric, dietary, and physical activity data were 
      gathered. Fasting blood samples were taken to measure biochemical parameters. 
      Serum Zn and vitamin A levels were measured via enzymatic-calorimetric and HPLC 
      methods, respectively. Results showed that serum Zn and vitamin A levels were 
      significantly lower in the PDR group than the controls (p = 0.03 and p = 0.008, 
      respectively). Serum low-density lipoprotein (LDL.C) was significantly higher in 
      the PDR than the control group (p = 0.02). Adjusting for the other variables, 
      increase in serum Zn and vitamin A levels reduced risk of DR by 25.7% and 31.1%, 
      respectively (p = 0.02 and p = 0.007). Higher serum LDL.C increased DR severity 
      by 28.7%, adjusted for the variables (95% CI = 0.002, 0.02; p = 0.01). Lower 
      serum Zn and vitamin A levels, as well as higher LDL.C in the T2DM patients, are 
      related to DR severity.
FAU - Rostamkhani, Hadi
AU  - Rostamkhani H
AD  - Department of Clinical Biochemistry, School of Medicine, Zanjan University of 
      Medical Sciences, Zanjan, Iran.
AD  - Student Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.
FAU - Mellati, Ali Awsat
AU  - Mellati AA
AD  - Department of Clinical Biochemistry, School of Medicine, Zanjan University of 
      Medical Sciences, Zanjan, Iran.
FAU - Tabaei, Banafsheh Sadat
AU  - Tabaei BS
AD  - Department of Clinical Biochemistry, School of Medicine, Zanjan University of 
      Medical Sciences, Zanjan, Iran.
FAU - Alavi, Mohammadhossein
AU  - Alavi M
AD  - Department of Biothechnology, School of Medicine, Zanjan University of Medical 
      Sciences, Zanjan, Iran.
FAU - Mousavi, Seyedeh Neda
AU  - Mousavi SN
AD  - Department of Nutrition, School of Medicine, Zanjan University of Medical 
      Sciences, Zanjan, Iran. neda.mousavi@zums.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20190221
PL  - United States
TA  - Biol Trace Elem Res
JT  - Biological trace element research
JID - 7911509
RN  - 11103-57-4 (Vitamin A)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Diabetic Retinopathy/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Vitamin A/*blood
MH  - Zinc/*blood
OTO - NOTNLM
OT  - Diabetic retinopathy
OT  - Type 2 diabetes
OT  - Vitamin A
OT  - Zinc
EDAT- 2019/02/23 06:00
MHDA- 2020/04/09 06:00
CRDT- 2019/02/22 06:00
PHST- 2018/10/16 00:00 [received]
PHST- 2019/02/04 00:00 [accepted]
PHST- 2019/02/23 06:00 [pubmed]
PHST- 2020/04/09 06:00 [medline]
PHST- 2019/02/22 06:00 [entrez]
AID - 10.1007/s12011-019-01664-z [pii]
AID - 10.1007/s12011-019-01664-z [doi]
PST - ppublish
SO  - Biol Trace Elem Res. 2019 Dec;192(2):123-128. doi: 10.1007/s12011-019-01664-z. 
      Epub 2019 Feb 21.