PMID- 30793428
OWN - NLM
STAT- MEDLINE
DCOM- 20200709
LR  - 20200709
IS  - 1468-1331 (Electronic)
IS  - 1351-5101 (Print)
IS  - 1351-5101 (Linking)
VI  - 26
IP  - 6
DP  - 2019 Jun
TI  - The minimum clinically important difference: which direction to take.
PG  - 850-855
LID - 10.1111/ene.13941 [doi]
AB  - Over the past decades in modern medicine, there has been a shift from statistical 
      significance to clinical relevance when it comes to interpreting results from 
      clinical trials. A concept that is increasingly being used as a surrogate for 
      clinical relevance and effect size calculation is the minimum clinically 
      important difference (MCID). In this paper, an overview is presented of the most 
      important aspects of the MCID concept used in research trials and a discussion of 
      what this means for the neurological patient in clinical trials and daily 
      practice is given. Is the MCID the best outcome measure cut-off to be 
      implemented?
CI  - (c) 2019 The Authors. European Journal of Neurology published by John Wiley & Sons 
      Ltd on behalf of European Academy of Neurology.
FAU - Draak, T H P
AU  - Draak THP
AUID- ORCID: 0000-0002-3810-9007
AD  - Department of Neurology, Maastricht University Medical Centre+, Maastricht, The 
      Netherlands.
FAU - de Greef, B T A
AU  - de Greef BTA
AUID- ORCID: 0000-0003-1698-1301
AD  - Department of Neurology, Maastricht University Medical Centre+, Maastricht, The 
      Netherlands.
AD  - Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht 
      University Medical Centre+, Maastricht, The Netherlands.
FAU - Faber, C G
AU  - Faber CG
AUID- ORCID: 0000-0002-2467-067X
AD  - Department of Neurology, Maastricht University Medical Centre+, Maastricht, The 
      Netherlands.
FAU - Merkies, I S J
AU  - Merkies ISJ
AD  - Department of Neurology, Maastricht University Medical Centre+, Maastricht, The 
      Netherlands.
AD  - Department of Neurology, St Elisabeth Hospital, Willemstad, Curacao.
CN  - PeriNomS study group
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190325
PL  - England
TA  - Eur J Neurol
JT  - European journal of neurology
JID - 9506311
SB  - IM
MH  - Humans
MH  - *Minimal Clinically Important Difference
MH  - *Neurology
MH  - Treatment Outcome
PMC - PMC6593833
OTO - NOTNLM
OT  - minimum clinically important difference (MCID)
COIS- Thomas H.P. Draak reports no disclosures. Bianca T.A. de Greef reports a grant 
      from Prinses Beatrix Spierfonds (W.OR12-01), outside the submitted work. 
      Catharina G. Faber reports grants from European Union's Horizon 2020 research and 
      innovation programme Marie Sklodowska-Curie grant for PAIN-Net, Molecule-to-man 
      pain network (grant no. 721841), grants from Prinses Beatrix Spierfonds 
      (W.OR15-25), grants from Grifols and Lamepro for a trial on IVIg in small fibre 
      neuropathy, and other from steering committees/advisory board for studies in 
      small fibre neuropathy of Biogen/Convergence, Vertex and Chromocell, outside the 
      submitted work. Ingemar S.J. Merkies received funding for research from the 
      Talecris Talents programme, CIDP/GBS Foundation International, Prinses Beatrix 
      Spierfonds and the European Union 7th Framework Programme (grant number 602273). 
      Furthermore, a research foundation at the University of Maastricht received 
      honoraria on his behalf for participation in steering committees of the Talecris 
      ICE Study, Laboratoire francais du Fractionnement et des Biotechnologies, CSL 
      Behring, Novartis, Grifols and Octapharma. He serves on the editorial board of 
      the Journal of the Peripheral Nervous System, is a member of the Inflammatory 
      Neuropathy Consortium and is a member of the Peripheral Nerve Society.
EDAT- 2019/02/23 06:00
MHDA- 2020/07/10 06:00
PMCR- 2019/06/26
CRDT- 2019/02/23 06:00
PHST- 2018/11/06 00:00 [received]
PHST- 2019/02/19 00:00 [accepted]
PHST- 2019/02/23 06:00 [pubmed]
PHST- 2020/07/10 06:00 [medline]
PHST- 2019/02/23 06:00 [entrez]
PHST- 2019/06/26 00:00 [pmc-release]
AID - ENE13941 [pii]
AID - 10.1111/ene.13941 [doi]
PST - ppublish
SO  - Eur J Neurol. 2019 Jun;26(6):850-855. doi: 10.1111/ene.13941. Epub 2019 Mar 25.