PMID- 30796757
OWN - NLM
STAT- MEDLINE
DCOM- 20200124
LR  - 20200225
IS  - 1720-8386 (Electronic)
IS  - 0391-4097 (Linking)
VI  - 42
IP  - 9
DP  - 2019 Sep
TI  - Reliability of calcium-phosphorus (Ca/P) ratio as a new, accurate and inexpensive 
      tool in the diagnosis of some Ca-P disorders.
PG  - 1041-1049
LID - 10.1007/s40618-019-01025-6 [doi]
AB  - PURPOSE: The serum calcium/phosphorus (Ca/P) ratio is an accurate tool to 
      differentiate patients with primary hyperparathyroidism (PHPT) from healthy 
      subjects. However, other disorders of the Ca-P metabolism might impair the Ca/P 
      ratio, such as hypophosphatemia (HypoP) not PHPT related. The aim of this study 
      is to examine the diagnostic value of Ca/P ratio in the diagnosis of PHPT and 
      HypoP not PHPT related. METHODS: Single-center, retrospective, case-control 
      study, including 150 patients with PHPT and 306 patients with HypoP, compared 
      with 150 controls. HypoP patients were enrolled among HIV-infected patients by 
      selecting those with Fanconi-like syndrome due to antiretroviral treatment. 
      Parameters which were measured were serum Ca, P, parathyroid hormone (PTH), 25-OH 
      vitamin D, albumin and creatinine). RESULTS: The Ca/P ratio was significantly 
      higher in PHPT and HypoP patients, compared to controls (p < 0.0001). At receiver 
      operator characteristic (ROC) curve analysis, the cut-off of 3.56 (2.75 SI) for 
      Ca/P ratio was able to identify patients with PHPT and HypoP (sensitivity 95%; 
      specificity 93%). Among patients with Ca/P ratio above 3.56, the thresholds of 
      10.3 mg/dL (2.6 mmol/L) for serum Ca (sensitivity 93%; specificity 98%) and 
      80.5 pg/mL for PTH (sensitivity 91%; specificity 91%) were defined for the 
      specific diagnosis of PHPT. CONCLUSIONS: The Ca/P ratio above 3.56 (2.75 SI) is a 
      highly accurate tool to identify PHPT and HypoP not PHPT-related patients. Thanks 
      to its simplicity, this index can be proposed as a screening and first-line 
      examination in the diagnostic work-up when a disorder of Ca-P metabolism is 
      suspected or should be ruled out.
FAU - Madeo, B
AU  - Madeo B
AUID- ORCID: 0000-0003-2881-982X
AD  - Unit of Endocrinology, Department of Medical Specialties, Azienda 
      Ospedaliero-Universitaria of Modena, Ospedale Civile di Baggiovara, Modena, 
      Italy. bruno.madeo@unimore.it.
FAU - De Vincentis, S
AU  - De Vincentis S
AUID- ORCID: 0000-0002-9582-5683
AD  - Unit of Endocrinology, Department of Medical Specialties, Azienda 
      Ospedaliero-Universitaria of Modena, Ospedale Civile di Baggiovara, Modena, 
      Italy.
AD  - Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, 
      University of Modena and Reggio Emilia, Modena, Italy.
FAU - Kara, E
AU  - Kara E
AD  - Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, 
      University of Modena and Reggio Emilia, Modena, Italy.
AD  - Endocrinology and Metabolism Unit, University Hospital of Udine, Udine, Italy.
FAU - Vescini, F
AU  - Vescini F
AUID- ORCID: 0000-0003-1892-9785
AD  - Endocrinology and Metabolism Unit, University Hospital of Udine, Udine, Italy.
FAU - Trenti, T
AU  - Trenti T
AD  - Department of Laboratory Medicine and Pathological Anatomy, Azienda USL of 
      Modena, Modena, Italy.
FAU - Guaraldi, G
AU  - Guaraldi G
AUID- ORCID: 0000-0002-5724-3914
AD  - Multidisciplinary Metabolic Clinic, Unit of Infectious Diseases, University of 
      Modena and Reggio Emilia, Modena, Italy.
FAU - Rochira, V
AU  - Rochira V
AUID- ORCID: 0000-0001-8169-0696
AD  - Unit of Endocrinology, Department of Medical Specialties, Azienda 
      Ospedaliero-Universitaria of Modena, Ospedale Civile di Baggiovara, Modena, 
      Italy.
AD  - Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, 
      University of Modena and Reggio Emilia, Modena, Italy.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20190222
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
RN  - 0 (Biomarkers)
RN  - 27YLU75U4W (Phosphorus)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/*metabolism
MH  - Calcium/*metabolism
MH  - Case-Control Studies
MH  - Female
MH  - Follow-Up Studies
MH  - HIV/isolation & purification
MH  - HIV Infections/complications/*metabolism/virology
MH  - Humans
MH  - Hyperparathyroidism, Primary/complications/*diagnosis/metabolism
MH  - Hypophosphatemia/complications/*diagnosis/metabolism
MH  - Male
MH  - Middle Aged
MH  - Phosphorus/*metabolism
MH  - Prognosis
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - Calcium-phosphorus metabolism
OT  - Hyperparathyroidism
OT  - Hypophosphatemia
OT  - Screening
EDAT- 2019/02/24 06:00
MHDA- 2020/01/25 06:00
CRDT- 2019/02/24 06:00
PHST- 2018/12/31 00:00 [received]
PHST- 2019/02/13 00:00 [accepted]
PHST- 2019/02/24 06:00 [pubmed]
PHST- 2020/01/25 06:00 [medline]
PHST- 2019/02/24 06:00 [entrez]
AID - 10.1007/s40618-019-01025-6 [pii]
AID - 10.1007/s40618-019-01025-6 [doi]
PST - ppublish
SO  - J Endocrinol Invest. 2019 Sep;42(9):1041-1049. doi: 10.1007/s40618-019-01025-6. 
      Epub 2019 Feb 22.